Entry
Name
FAD-AMP lyase (cyclizing);
FMN cyclase;
FAD AMP-lyase (cyclic-FMN-forming)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming)
Reaction(IUBMB)
FAD = AMP + riboflavin cyclic-4',5'-phosphate [RN:
R07636 ]
Reaction(KEGG)
Substrate
Product
AMP [CPD:
C00020 ];
riboflavin cyclic-4',5'-phosphate [CPD:
C16071 ]
Comment
Requires Mn2+ or Co2+. While FAD was the best substrate tested [2], the enzyme also splits ribonucleoside diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide or derivative bearing an X-OH group that is able to attack internally the proximal phosphorus with the geometry necessary to form a P=X product; either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion. The reaction is strongly inhibited by ADP or ATP but is unaffected by the presence of the product, cFMN.
History
EC 4.6.1.15 created 2002
Orthology
K00863 triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing)
Genes
PPRM : 120469829 120470392
PPRL : 129356671 129379938
LERI : 129705830(tkfc) 129705831
BBEL : 109472260 109475013
AALB : 109409004 109412500 109621976 115257995 115264944
CQU : CpipJ_CPIJ006434 CpipJ_CPIJ016133
CPII : 120412634 120422699
MGEN : 117221741 117228052
RSAN : 119376668 119401707
CEL : CELE_W02H5.8(W02H5.8)
PVUL : 126821117 126822675
CANU : 128176691 128176693
PALZ : 118044323 118051018
SCE : YFL053W(DAK2) YML070W(DAK1)
SEUB : DI49_1319 DI49_4021
SPAO : SPAR_F00070 SPAR_M00620
LTH : KLTH0B00418g KLTH0D16412g
NCS : NCAS_0A06130(NCAS0A06130)
NDI : NDAI_0D03110(NDAI0D03110)
TPF : TPHA_0B01670(TPHA0B01670)
TBL : TBLA_0B06340(TBLA0B06340)
TDL : TDEL_0C00180(TDEL0C00180) TDEL_0D00840(TDEL0D00840)
KAF : KAFR_0I00330(KAFR0I00330)
KNG : KNAG_0E04050(KNAG0E04050)
ZMK : HG535_0B00260 HG535_0E01760
DHA : DEHA2A03542g DEHA2B12892g
SPAA : SPAPADRAFT_139806 SPAPADRAFT_151697 SPAPADRAFT_72612
CAL : CAALFM_C109190CA(DAK2)
CTEN : CANTEDRAFT_109630 CANTEDRAFT_97792
OPA : HPODL_01039 HPODL_04538
NCR : NCU03779(dak-1) NCU04400
NTE : NEUTE1DRAFT121216(NEUTE1DRAFT_121216) NEUTE1DRAFT58250(NEUTE1DRAFT_58250)
SMP : SMAC_02626 SMAC_07350
PAN : PODANSg7445 PODANSg9015
PBEL : QC761_211570(dak1) QC761_601010
PPSD : QC762_211570(dak1) QC762_601010
PPSP : QC763_211570(dak1) QC763_601010
PPSA : QC764_211570(dak1) QC764_601010
TTT : THITE_2040308 THITE_2108431 THITE_2114839
MTM : MYCTH_2302225 MYCTH_40719
PPEI : PpBr36_04491 PpBr36_09502
PGRI : PgNI_06903 PgNI_10247
TMN : UCRPA7_6890 UCRPA7_7089
FGR : FGSG_07017 FGSG_08042
FPU : FPSE_02329 FPSE_02774
FPOA : FPOAC1_010775 FPOAC1_013122
FOX : FOXG_01790 FOXG_04497
NHE : NECHADRAFT_63627 NECHADRAFT_94691
FFC : NCS54_00864000 NCS54_01150900 NCS54_01503900
FKR : NCS57_00476800 NCS57_00906100 NCS57_01141300
FMU : J7337_002794 J7337_010366 J7337_011510
TRE : TRIREDRAFT_4480 TRIREDRAFT_68466
TRR : M419DRAFT_130671 M419DRAFT_26548
PCHM : VFPPC_03185 VFPPC_05893 VFPPC_08304 VFPPC_08312
CMT : CCM_01642 CCM_03212 CCM_08253
AMUS : LMH87_001276 LMH87_002450 LMH87_003445
PLJ : VFPFJ_08028 VFPFJ_09339
PTKZ : JDV02_002356 JDV02_005068(dak1) JDV02_009403
VAL : VDBG_07518 VDBG_07610 VDBG_07776
VDA : VDAG_09239 VDAG_09331 VDAG_09648
CFJ : CFIO01_01160 CFIO01_02503 CFIO01_03078 CFIO01_06023
CLUP : CLUP02_07917 CLUP02_12908 CLUP02_16847 CLUP02_17623
CHIG : CH63R_04175 CH63R_06617 CH63R_12165
ELA : UCREL1_5454 UCREL1_9085
ACHE : ACHE_41301S ACHE_80736A
POU : POX_d05390 POX_f08145
TMF : EYB26_001827 EYB26_008813
TRG : TRUGW13939_05334 TRUGW13939_05491
PNO : SNOG_10035 SNOG_10451
BZE : COCCADRAFT_27327 COCCADRAFT_9558
BSC : COCSADRAFT_141387 COCSADRAFT_29733
BOR : COCMIDRAFT_33722 COCMIDRAFT_3711
AALT : CC77DRAFT_1022806 CC77DRAFT_929939
ARAB : EKO05_0005282 EKO05_0007737
ZTR : MYCGRDRAFT_54399 MYCGRDRAFT_76425
PFJ : MYCFIDRAFT_158677 MYCFIDRAFT_59700
FFU : CLAFUR5_01064 CLAFUR5_03250 CLAFUR5_08051 CLAFUR5_08191
CBET : CB0940_01334 CB0940_02325 CB0940_04153 CB0940_04194
BCOM : BAUCODRAFT_192470 BAUCODRAFT_420155
SPO : SPAC22A12.11(dak1) SPAC977.16c(dak2)
CNG : CNAG_00826 CNAG_02799
CGI : CGB_A9430C CGB_C6280C
CDEU : CNBG_1112 CNBG_3454
TMS : TREMEDRAFT_29967 TREMEDRAFT_32898
TASA : A1Q1_00056 A1Q1_01002
CCAC : CcaHIS019_0103320(CcaverHIS019_0103320) CcaHIS019_0411730(CcaverHIS019_0411730)
SHS : STEHIDRAFT_139617 STEHIDRAFT_58915
FME : FOMMEDRAFT_166668 FOMMEDRAFT_73790
GTR : GLOTRDRAFT_74971 GLOTRDRAFT_96970
ABP : AGABI1DRAFT90110(AGABI1DRAFT_90110)
ABV : AGABI2DRAFT222826(AGABI2DRAFT_222826)
MRR : Moror_17275 Moror_9773
MORE : E1B28_006914 E1B28_007669
SCM : SCHCO_02545094(SCHCODRAFT_02545094) SCHCO_02619084(SCHCODRAFT_02619084)
CPUT : CONPUDRAFT_138892 CONPUDRAFT_83570
WSE : WALSEDRAFT_53995(DAK-1)
ECLN : ECNIH4_02825 ECNIH4_18150
ECHG : FY206_05665 FY206_21960
KPZ : KPNIH27_22110 KPNIH27_28410
KOK : KONIH1_05860 KONIH1_25735
KLL : BJF97_25400 BJF97_29770
RTG : NCTC13098_00821(dhaK_1)
CTEL : GBC03_01435 GBC03_27480
PGE : LG71_00675 LG71_13210
TOE : QMG90_02550 QMG90_16965
BPM : BURPS1710b_2248(dak)
SFD : USDA257_c27550(dhaK3)
REC : RHECIAT_CH0002635(dhaK)
RHL : LPU83_pLPU83c0203(dhaK3)
RAD : CO657_11305 CO657_25965
CMET : K6K41_10610 K6K41_24145
BAH : BAMEG_3604 BAMEG_3606
BAX : H9401_0913 H9401_0915
BANT : A16_10360 A16_10380
BANR : A16R_10480 A16R_10500
BANS : BAPAT_0921 BAPAT_0923
BANH : HYU01_05125 HYU01_05135
BANV : DJ46_5425(dhaK2) DJ46_5427(dhaK)
BCR : BCAH187_A1132(dhaK) BCAH187_A1134
BCU : BCAH820_1047 BCAH820_1049
BCQ : BCQ_1042 BCQ_1044(dhaL)
BTK : BT9727_0887(dhaL) BT9727_0889(dhaL)
BTW : BF38_2210(dhaK2) BF38_2212(dhaK)
BWD : CT694_05315(dhaK2) CT694_05330
BTRO : FJR70_26950(dhaQ) FJR70_26965(dhaK)
BPAN : NLJ82_05100(dhaQ) NLJ82_05110(dhaK)
BALU : QRY64_07405(dhaQ) QRY64_07415(dhaK)
PPQ : PPSQR21_037460(dAK1)
PNK : AASFL403_06745(dhaK)
VLC : G314FT_00950(dhaK_1)
ACEL : acsn021_24320(dhaK)
MAUU : NCTC10437_05243(dhaK_2)
» show all
Taxonomy
Reference
Authors
Fraiz FJ, Pinto RM, Costas MJ, Aavalos M, Canales J, Cabezas A, Cameselle JC.
Title
Enzymic formation of riboflavin 4',5'-cyclic phosphate from FAD: evidence for a specific low-Km FMN cyclase in rat liver1.
Journal
Reference
Authors
Cabezas A, Pinto RM, Fraiz F, Canales J, Gonzalez-Santiago S, Cameselle JC
Title
Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.15
ExPASy - ENZYME nomenclature database: 4.6.1.15