KEGG ENZYME: 5.1.3.24

ENZYME: 5.1.3.24

Entry

EC 5.1.3.24                 Enzyme

Name

N-acetylneuraminate epimerase;
sialic acid epimerase;
N-acetylneuraminate mutarotase;
NanM;
NanQ

Class

Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives

Sysname

N-acetyl-alpha-neuraminate 2-epimerase

Reaction(IUBMB)

N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate (oveall reaction) [RN:R09797];
(1a) N-acetyl-alpha-neuraminate = aceneuramate [RN:R12769];
(1b) aceneuramate = N-acetyl-beta-neuraminate [RN:R12770]

Reaction(KEGG)

R09797 R12769 R12770

Substrate

N-acetyl-alpha-neuraminate [CPD:C19909];
aceneuramate [CPD:C22382]

Product

N-acetyl-beta-neuraminate [CPD:C19910];
aceneuramate [CPD:C22382]

Comment

Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria.

History

EC 5.1.3.24 created 2011, modified 2021

Orthology

K17948

N-acetylneuraminate epimerase

Genes

ECO:	b4310(nanM)

ECJ:	JW5777(yjhT)

ECD:	ECDH10B_4513(yjhT)

EBW:	BWG_4008(nanM)

ECOC:

C3026_23270

ECE:	Z5906(yjhT)

ECS:	ECs_5269(yjhT)

ECF:	ECH74115_5814

ETW:	ECSP_5392(yjhT)

ELX:	CDCO157_4954

EOI:	ECO111_5164(nanM)

EOJ:	ECO26_5507(nanM)

EOH:	ECO103_5091(nanM)

ECOO:

ECRM13514_5553(yjhT)

ECOH:

ECRM13516_5268(yjhT)

ECG:	E2348C_4617(yjhT)

EOK:	G2583_5111(yjhT)

ELR:	ECO55CA74_24620

ELH:

ETEC_4622

ECW:	EcE24377A_4909

ECP:

ECP_4643

ENA:	ECNA114_4554(yjhT)

ECOS:

EC958_0038 EC958_3297

ECV:	APECO1_2121(yjhT)

ECOA:

APECO78_02685

ECX:	EcHS_A4535

ECM:	EcSMS35_4835

ECY:

ECSE_4582

ECR:	ECIAI1_4523(yjhT)

ECQ:	ECED1_4916 ECED1_5194(yjhT)

EUM:	ECUMN_3380 ECUMN_4915(yjhT)

ECT:	ECIAI39_4781(yjhT)

EOC:	CE10_5054(nanM)

EBR:	ECB_04177(yjhT)

ECOB:

C3029_03765

EBL:	ECD_04177(nanM)

EBE:	B21_04139(nanM)

EBD:

ECBD_3727

ECI:	UTI89_C5006

EIH:	ECOK1_4808

ECZ:	ECS88_4927(yjhT)

ECC:	c3634 c5388

ELO:	EC042_4821

ELN:	NRG857_21740

ESE:

ECSF_4250

EKO:	EKO11_4006

EKF:	KO11_23175(nanM)

EAB:	ECABU_c33050 ECABU_c49520

EDH:	EcDH1_3688

EDJ:	ECDH1ME8569_4169(yjhT)

ELU:	UM146_22235

ELW:	ECW_m4667(nanM)

ELL:	WFL_22730(nanM)

ELC:	i14_3329 i14_4906

ELD:	i02_3329 i02_4906

ELF:	LF82_3478(yjhT)

ECOL:

LY180_22610

ECOI:

ECOPMV1_04756(nanM)

ECOJ:

P423_16480 P423_24505

EAL:	EAKF1_ch1544

ESZ:	FEM44_14110

ERUY:

OSH18_10010

STY:

STY1167

STT:

t1790

SEX:	STBHUCCB_19010

SENT:

TY21A_09095

STM:

STM1130

SEO:	STM14_1293

SEV:	STMMW_11391

SEY:	SL1344_1068

SEM:	STMDT12_C11490

SEJ:	STMUK_1098

SEB:	STM474_1124

SEF:	UMN798_1175

SETU:

STU288_01980

SETC:

CFSAN001921_11530

SENR:

STMDT2_10651

SEND:

DT104_11101

SENI:

CY43_05765

SEEN:

SE451236_11495

SPQ:	SPAB_02408

SEI:

SPC_2619

SEC:	SCH_1080(yjhT)

SEH:	SeHA_C1240

SHB:

SU5_01759

SENH:

CFSAN002069_03375

SEEH:

SEEH1578_14875

SEE:	SNSL254_A1225

SENN:

SN31241_21970

SEW:	SeSA_A1195

SED:

SeD_A1205

SEL:

SPUL_1927

SEGA:

SPUCDC_1913

SET:

SEN0991

SENA:

AU38_05120

SENO:

AU37_05110

SENV:

AU39_05110

SENQ:

AU40_05745

SENL:

IY59_05215

SENJ:

CFSAN001992_05995

SEEB:

SEEB0189_013925

SEEP:

I137_08760

SENB:

BN855_10880

SENE:

IA1_05560

SES:	SARI_01870

SALZ:

EOS98_13950

SFL:	SF4212(yjhT)

SFX:	S4469(yjhT)

SFV:	SFV_4217(yjhT)

SFE:

SFxv_4595

SFN:

SFy_6049

SFS:

SFyv_6119

SFT:	NCTC1_04579(yjhT)

SSN:	SSON_4472(yjhT)

SBO:	SBO_4360(yjhT)

SHQ:	A0259_03230

YPE:

YPO1858

YPK:

y2448

YPH:

YPC_2405

YPA:

YPA_1237

YPN:

YPN_2265

YPM:

YP_1535

YPP:	YPDSF_1267

YPG:	YpAngola_A2044

YPZ:

YPZ3_1871

YPT:	A1122_16570

YPD:

YPD4_1647

YPX:

YPD8_1903

YPW:	CH59_3308(nanM)

YPJ:	CH55_817(nanM)

YPV:	BZ15_1692(nanM)

YPL:	CH46_3265(nanM)

YPS:

YPTB1729

YPO:	BZ17_771(nanM)

YPI:	YpsIP31758_2260

YPY:

YPK_2362

YPB:

YPTS_1861

YPQ:	DJ40_491(nanM)

YPU:	BZ21_1083(nanM)

YPR:	BZ20_245(nanM)

YPC:	BZ23_1364(nanM)

YPF:	BZ19_1157(nanM)

YEN:

YE1943

YEP:	YE105_C1753

YEY:

Y11_13781

YEW:	CH47_1375(nanM)

YET:	CH48_3365(nanM)

YEF:	FORC2_2489

YEE:	YE5303_22951

YSI:	BF17_17915

YFR:	AW19_918(nanM)

YKR:

CH54_744

YRO:	CH64_268(nanM)

YRU:	BD65_2428(nanM)

YRB:	UGYR_12510

YAK:	ACZ76_00835

YMA:	DA391_09450

YHI:	D5F51_10580

YCA:	F0T03_12955

YMO:	HRD69_13900

YAS:	N0H69_16095

YKI:	HRD70_17670

YEG:	PL78_15995

PVG:	CRN77_04700

PCOL:

F1325_18500

PCIB:

F9282_19070

PPEE:

I6G31_10245

PHAG:

PZ638_17485

MMK:

MU9_1237

ETR:

ETAE_0932

ETD:	ETAF_0868(nanM)

ETE:

ETEE_2873

ETC:	ETAC_04450

EDW:	QY76_15510

EDL:	AAZ33_04945

EHO:	A9798_12110

HIN:

HI_0148

HIT:

NTHI0235

HIP:	CGSHiEE_02545

HIQ:	CGSHiGG_03330

HIF:	HIBPF_19720

HIL:	HICON_13250

HIU:

HIB_02010

HIE:	R2846_0489(nanM)

HIZ:	R2866_0439(nanM)

HIK:	HifGL_000825(nanM)

HIA:	H733_0032(nanM)

HIH:	NF38_04680

HIW:	NTHI477_01181(nanM)

HIC:	NTHIC486_00883(nanM)

HIX:	NTHI723_01555(nanM)

HAY:	C3V42_06650

HPIT:

NCTC13334_00443(nanM)

HHZ:	NCTC10839_01822(nanM)

HAEG:

NCTC8502_01090(nanM)

HSEM:

L3077_04460

PMU:

PM1707

PMV:	PMCN06_2150(nanM)

PUL:	NT08PM_2044

PMP:	Pmu_20710(nanM)

PMUL:

DR93_654(nanM)

PSKY:

A6B44_10030

PATL:

KGI96_08820

PCAI:

K7G93_001403

AAP:	NT05HA_0541

AAZ:	ADJ80_06975

AAT:

D11S_1586

AAO:	ANH9381_1957

AAN:

D7S_00408

AAH:	CF65_02476

AACN:

AANUM_1474

AACT:

ACT75_01640

ASEG:

NCTC10977_01728(nanM)

AGJ:	J5A60_05915

GAN:	UMN179_01671

GSS:	NYR30_00190

APAG:

EIA51_10115

AVT:	NCTC3438_00937(nanM)

RPNE:

NCTC8284_03406(nanM_2)

RHEY:

FEE42_05575

RHAE:

IHV77_04775

OOI:	A6A10_03740

FCL:	A4G17_06630

BHUD:

A6A11_01695

MSEP:

CEP49_05430

VCH:

VC_1774

VCF:	IR04_14055

VCS:

MS6_1547

VCE:	Vch1786_I1268

VCQ:	EN18_12020

VCJ:	VCD_002596

VCI:

O3Y_08590

VCO:	VC0395_A1372

VCR:	VC395_1888

VCM:	VCM66_1712

VCL:	VCLMA_A1536

VCZ:	VAB027_2447

VVU:

VV2_0726

VVY:	VVA1196 VVA1197

VVM:	VVMO6_04100 VVMO6_04101

VVL:	VV93_v1c41230 VV93_v1c41240

VEU:	IXK98_05330

VMI:	AL543_04580

VSC:	VSVS12_03139(nanM) VSVS12_03140

VSH:	BSZ05_25890 BSZ05_25895

VMT:	QYQ96_05420

PDS:	CAY62_15090

SPL:

Spea_1514

PSY:	PCNPT3_07910

CHJ:	NCTC10426_00703(nanM)

RHG:	EXZ61_13475

HFR:	G5S34_08795

GLC:	JQN73_01825

AAK:	AA2016_4369

BME:

BMEII0856

BMEL:

DK63_2392

BMI:	BMEA_B0390

BMZ:	BM28_B0384

BMG:	BM590_B0382

BMW:	BMNI_II0375

BMEE:

DK62_3015

BMF:

BAB2_0809

BMB:	BruAb2_0789

BMC:	BAbS19_II07480

BAA:	BAA13334_II01485

BABO:

DK55_2765

BABR:

DO74_3181

BABT:

DK49_2474

BABB:

DK48_3032

BABU:

DK53_2768

BABS:

DK51_2252

BABC:

DO78_2289

BSUI:

BSSP1_II0367

BSUP:

BSPT1_II0365

BSUV:

BSPT2_II0368

BSUC:

BSSP2_II0371

BMT:	BSUIS_B0415

BSZ:

DK67_2419

BSW:	IY71_13135

BSG:	IY72_12675

BOV:

BOV_A0355

BCS:	BCAN_B0415

BSK:	BCA52141_II0611

BOL:	BCOUA_II0412

BCAR:

DK60_2139

BCAS:

DA85_12455

BMR:

BMI_II409

BPP:

BPI_II394

BPV:

DK65_2091

BCET:

V910_200826

BRU:	BFS01_14195

BRJ:	BKD03_02810

BIO:	BR141012304_20247

MLD:	U0023_24885

DEI:	C4375_16440

DSAL:

K1X15_12935

PARU:

CYR75_06050

PSTL:

JHW45_17025

SCL:

sce5357

LGY:	T479_08755

GOT:	AXE85_00555

GMO:	NCTC11323_00012(nanM)

GEQ:	CG018_02310

GSA:	FOC50_04420

GHA:	NCTC10459_00013(nanM)

VIJ:	JNUCC6_03350

DPM:	FNV33_08660

CBUT:

ATN24_15385

MHW:	ACT01_13190

SELE:

ADJ74_04330

SELO:

AXE86_05610

MHG:

MHY_00950

MFUN:

GXM21_10670

KFL:

Kfla_0128

DDR:	Deide_3p01141

DFC:

DFI_16055

DEIN:

DAAJ005_09570

DPH:	EHF33_19580

DMB:	E5F05_01595

OBT:	OPIT5_23745

AGL:

PYTT_1911

ROO:	G5S37_09935

LUO:	HHL09_03715

PSL:

Psta_1238

PIR:	VN12_17085(nanM_1)

ROL:	CA51_38050(nanM_1)

PLS:	VT03_21000(nanM_2)

TIM:	GMBLW1_20220 GMBLW1_44300

LRS:	PX52LOC_04974

ULI:	ETAA1_10650(nanM_1)

PBU:	L21SP3_00912(nanM)

HBS:	IPV69_02750

BRM:

Bmur_2467

BPO:	BP951000_0927

BPJ:	B2904_orf437

BPIP:

BPP43_10440

BPW:

WESB_2249

BIP:

Bint_0697

BHP:	BHAMNSH16_10710

PFER:

IRI77_27135

FNC:	HMPREF0946_01160

FNT:	HMPREF0405_00242

FHW:	RN87_04355

FVA:	FV113G1_02100

FUL:	C4N20_05260

FMO:	C4N19_06915

FGO:	C4N16_07160

FNF:	BSQ88_06540

FCI:	I6I83_10425

SMF:

Smon_1051

BXY:

BXY_44770

BOA:	Bovatus_01545(nanM_1)

BCAC:

CGC64_15640

BCAE:

A4V03_11380

BVU:

BVU_4137

BDO:	EL88_15600

BDH:	GV66_22005

PCOP:

I6J50_17260

PBT:	ING2E5B_2376

PMUC:

ING2E5A_0814(nanM)

PET:	PEIBARAKI_6556

PSAC:

PSM36_2234

PDI:

BDI_2949

PARC:

CI960_20980

TFO:

BFO_2210

PARY:

A4V02_10410

COPR:

Cop2CBH44_31290

PMZ:	HMPREF0659_A6641

PDN:	HMPREF9137_2436

PDT:	Prede_1040

PRO:	HMPREF0669_00713

PFUS:

ADJ77_09660

PJE:	CRM71_09425

POC:	NCTC13071_00094(nanM)

PEO:	AS203_02645

DORI:

FH5T_13875

CHIT:

FW415_22780

NSO:	NIASO_04270 NIASO_17355

NIA:	A8C56_20460

FGG:	FSB75_00725

ARK:	D6B99_12645

AGI:	FSB73_06750

FLS:	GLV81_17610

LACS:

H4075_08735

PHE:	Phep_2212 Phep_3255 Phep_3569

PEP:	AQ505_14410

PGS:	CPT03_08035 CPT03_13135

PROE:

H9L23_05800

SHG:	Sph21_4585

SHT:	KO02_01190

SPHN:

BV902_06625

SMIZ:

4412673_03728(nanM_2)

SPSC:

E2P86_07235

SPHZ:

E3D81_00295 E3D81_09385

SPHE:

GFH32_00785 GFH32_12215

SDJ:	NCTC13534_05183(nanM_2)

STHA:

NCTC11429_02641(nanM_1) NCTC11429_04305(nanM_2)

SMUI:

I6J00_22050

SSIY:

JVX97_26645

MRUB:

DEO27_011530

MGIK:

GO620_002240

OLI:	FKG96_20860

SBX:	CA265_04840

SLI:

Slin_2624

ASWU:

HUW51_05915

COC:

Coch_2065

COL:	AM608_02860

CHG:	AXF12_07720

CAPN:

CBG49_11685

CLK:	CGC53_09515

CSPU:

CGC55_13480

CAPF:

FOC45_03360

CAPO:

HW278_00530

ELT:	FGE20_11205

» show all

Reference

1 [PMID:18063573]

Authors

Severi E, Muller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH

Title

Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT.

Journal

J Biol Chem 283:4841-9 (2008)
DOI:10.1074/jbc.M707822200

Sequence

[eco:b4310]

Reference

2 [PMID:33895133]

Authors

Kentache T, Thabault L, Deumer G, Haufroid V, Frederick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E.

Title

The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.

Journal

J Biol Chem 296:100699 (2021)
DOI:10.1016/j.jbc.2021.100699

Other DBs

ExplorEnz - The Enzyme Database:

5.1.3.24

IUBMB Enzyme Nomenclature:

5.1.3.24

ExPASy - ENZYME nomenclature database:

5.1.3.24

BRENDA, the Enzyme Database:

5.1.3.24

DBGET integrated database retrieval system