ENZYME: 5.1.99.6 Help
Entry
Name
NAD(P)H-hydrate epimerase;
NAD(P)HX epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on other compounds
BRITE hierarchy
Sysname
(6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase
Reaction(IUBMB)
(1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide [RN:
R10280 ];
(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate [RN:
R10281 ]
Reaction(KEGG)
Substrate
(6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide [CPD:
C20482 ];
(6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate [CPD:
C20483 ]
Product
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide [CPD:
C04856 ];
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate [CPD:
C04899 ]
Comment
The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate. Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC
4.2.1.93 , ATP-dependent NAD(P)H-hydrate dehydratase.
History
EC 5.1.99.6 created 2012
Orthology
K17759 NAD(P)H-hydrate epimerase
K23997 ADP-dependent NAD(P)H-hydrate dehydratase / NAD(P)H-hydrate epimerase
K23998 pyridoxal 5'-phosphate synthase / NAD(P)H-hydrate epimerase
Genes
MAUA : 101823930(Naxe) 121142828
DSP : 122103333 122109419(Naxe)
ETF : 101638627 101649983(NAXE)
SANH : 107669985 107693306
CAUA : 113061933 113119961
CGIB : 127934990 127978567
MASI : 127421011 127425635
ARUT : 117395141 117970228
DSI : Dsimw501_GD24551(Dsim_GD24551)
AALB : 109416867 109623093
AGRG : 126746341 126749718
PPYR : 116162882 116164975
CFEL : 113385173 113385339
SGRE : 126282203 126318620
PPOI : 119101144 119101507
LPOL : 106459302 106472849
CEL : CELE_Y18D10A.3(Y18D10A.3)
HRF : 124128025 124128027 125371622
CVN : 111111116 111112266 111112513 111112515 111113836 111113875 111113879
CANU : 128161378 128171027
RPHI : 132713892 132713895 132715301 132717563 132723397 132723398 132725849 132728531 132742723 132744421 132745470
DPOL : 127867914 127867918
SHX : MS3_00001772(APOA1BP)
CSAT : 104724557 104725505 104760987
CIC : CICLE_v10000790mg CICLE_v10001057mg
PVY : 116129096 116129511 116141296
MINC : 123202574 123230214
HSYR : 120118510 120176797
LJA : Lj1g3v1615290.1(Lj1g3v1615290.1) Lj1g3v1615290.2(Lj1g3v1615290.2)
LANG : 109327074 109340727 109340728
QSA : O6P43_015360 O6P43_019589
MSYL : 126605402 126631554
MESC : 110605585 110606729
SPEN : 107014825 107014876
SSTN : 125857893 125859386
CANN : 107862446 107862447
NTA : 107759856 107806353 107826837
SIND : 105157165 105157166
OEU : 111387597 111387599 111400456
SSPL : 121762520 121763886 121787446 121787532
SMIL : 131021227 131021228
SHIS : 125192964 125209852 125216535
CSIN : 114280228 114289217 114311251
PSOM : 113289423 113297021
DOSA : Os10t0377800-01(Os10g0377800)
TAES : 123127805 123137560 123144910
PVIR : 120651195 120691031
MSIN : 131234875 131242399
SMO : SELMODRAFT_159735 SELMODRAFT_81184
MPP : MICPUCDRAFT_44681(JGI:MicpuC2_44681)
NCS : NCAS_0G01630(NCAS0G01630)
NDI : NDAI_0F03550(NDAI0F03550)
TPF : TPHA_0H00880(TPHA0H00880)
TBL : TBLA_0G00400(TBLA0G00400)
TDL : TDEL_0A00910(TDEL0A00910)
KAF : KAFR_0A07720(KAFR0A07720)
KNG : KNAG_0F01100(KNAG0F01100)
CAL : CAALFM_C102220CA(CaO19.3679)
NTE : NEUTE1DRAFT88765(NEUTE1DRAFT_88765)
SPO : SPAC15A10.05c(mug182)
CCAC : CcaHIS019_0307080(CcaverHIS019_0307080)
ABP : AGABI1DRAFT108868(AGABI1DRAFT_108868)
ABV : AGABI2DRAFT181137(AGABI2DRAFT_181137)
SCM : SCHCO_02491176(SCHCODRAFT_02491176)
EHI : EHI_136490(33.t00034)
ECOO : ECRM13514_5431(yjeF)
ECOH : ECRM13516_5180(yjeF)
EDJ : ECDH1ME8569_4024(yjeF)
ECOI : ECOPMV1_04630(nnr_1)
REE : electrica_04640(nnr)
RTG : NCTC13098_06717(nnr)
CLAP : NCTC11466_04098(nnr)
KIE : NCTC12125_03309(nnr)
AHN : NCTC12129_04451(nnr)
METY : MRY16398_50940(yjeF)
PSHI : SAMEA2665130_2743(nnr)
SMW : SMWW4_v1c03680(yjeF)
SFJ : SAMEA4384070_0446(nnr)
SOF : NCTC11214_01178(nnr)
TPTY : NCTC11468_03283(nnr_2)
LRI : NCTC12151_03124(nnr)
XPH : XppCFBP6546_00960(XppCFBP6546P_00960)
VPL : SA104470976_03058(nnr)
PAEB : NCGM1900_5695(yjeF)
PNB : NK667_10880 NK667_24550
ABD : ABTW07_1233 ABTW07_1745
SCAA : TUM17387_06190(yjeF)
LPH : LPV_3047(yjeF) LPV_3175
LPO : LPO_2982(yjeF) LPO_3114
LPU : LPE509_00208 LPE509_00324
LLG : 44548918_02285(yjeF)
LJR : NCTC11533_02372(yjeF)
LCJ : NCTC11976_00258(yjeF)
LWA : SAMEA4504053_3200(nnr)
LSS : NCTC12082_01488(yjeF)
LADL : NCTC12735_01531(yjeF)
MISZ : MishRS11D_15190(nnr)
THIO : AYJ59_03135 AYJ59_04105
TNI : TVNIR_2782(yjeF_[H])
HAXI : HAALTHF_30880n HAALTHF_30890n
MMW : Mmwyl1_1965 Mmwyl1_3063
AEL : NCTC12917_03439(nnr)
CHJ : NCTC10426_01762(nnr)
NWE : SAMEA3174300_0641(nnr_2)
NZO : SAMEA4504057_1428(nnr_2)
NCI : NCTC10296_01916(nnr_2)
NANI : NCTC12227_00711(nnr_2)
ECOR : SAMEA4412678_1665(nnr_1)
REH : H16_A1504(h16_A1504)
BUE : BRPE67_ACDS12650(yjeF)
PLG : NCTC10937_00750(nnr)
LMIR : NCTC12852_01899(nnr)
BTRM : SAMEA390648703821(nnr_2)
AXX : ERS451415_01646(nnr_2)
AMON : H9L24_07540 H9L24_20040
VAA : AX767_03820 AX767_18800
URU : DSM104443_02389(nnr)
UPL : DSM104440_02132(nnr)
RBS : RHODOSMS8_00829(nnr)
MTUN : MTUNDRAET4_3844(nnrE)
TSV : DSM104635_01949(nnr)
RLI : RLO149_c019830 RLO149_c019840
SPSE : SULPSESMR1_01067(nnr)
RMM : ROSMUCSMR3_00617(nnr)
AHT : ANTHELSMS3_03770(nnr)
RSK : RSKD131_1482 RSKD131_1483
RCP : RCAP_rcc01671 RCAP_rcc01672
RHP : LPB142_07880 LPB142_07885
LVS : LOKVESSMR4R_01729(nnr)
FAQ : G5B39_06960 G5B39_06965
SFLA : SPHFLASMR4Y_00838(nnr)
POQ : KZX46_01365 KZX46_15965
PMEA : KTC28_14155 KTC28_20025
LCK : HN018_11220 HN018_25315
HCL : NCTC13205_00773(nnr)
HPUL : NCTC13154_01349(nnr)
GBN : GEOBRER4_28640(yjeF)
PACE : A6070_03045 A6070_03180
DFI : AXF13_04300 AXF13_06075
DPG : DESPIGER_0330 DESPIGER_0666
DEF : CNY67_07165 CNY67_09665
DAF : Desaf_2722 Desaf_2781
DEJ : AWY79_01970 AWY79_12625
DDN : DND132_0356 DND132_2383
DSX : GD604_04945 GD604_11100
DSD : GD606_00665 GD606_07445
DOA : AXF15_00485 AXF15_09720
DPR : Despr_0462 Despr_1092
DAT : HRM2_35850 HRM2_44810
DTO : TOL2_C03400 TOL2_C10880
DOV : DSCO28_11910(yjeF) DSCO28_28400
DWD : DSCW_15500(yjeF) DSCW_27260
DALK : DSCA_14900(nnr) DSCA_25060
DLI : dnl_21720(nnr) dnl_46680
DMM : dnm_054500 dnm_058340(nnr)
DAO : Desac_0456 Desac_0729
DTI : Desti_1677 Desti_4224
DAX : FDQ92_02385 FDQ92_08665
TID : Thein_0053 Thein_1837
TOP : TOPB45_0012 TOPB45_1238
TCM : HL41_00185 HL41_03780
SCU : SCE1572_02535 SCE1572_26130
VPN : A21D_02035(nnr_1) A21D_02036(nnr_2)
NTM : BTDUT50_05720 BTDUT50_14640
SURE : SporoP32a_04690 SporoP32a_04695
LOR : AYI71_05025 AYI71_09605
CTET : BN906_02758 BN906_02759
CCOH : SAMEA4530647_2214(nnr)
CAML : H6X83_03685 H6X83_08160
PFAA : MM59RIKEN_32770(nnr)
BPRO : PMF13cell1_03748(nnr)
CSCI : HDCHBGLK_02933(nnr)
CHYL : CE91St63_16950(nnr)
CBAR : PATL70BA_3289(nnrE)
AMIC : Ami3637_01305 Ami3637_01640
ABUT : Ami103574_07275 Ami103574_07635
EAC : EAL2_808p03930 EAL2_c09240(yjeF)
TPZ : Tph_c18570 Tph_c19240
CDIA : CaldiYA01_06570(nnr)
PIV : NCTC13079_01045(nnr)
HOV : EQF90_001260 EQF90_001705
KPAR : JL105_01435 JL105_10390
VDN : NCTC11831_00850(nnr)
DHO : Dia5BBH33_13680(nnr)
PFAC : PFJ30894_02268(nnr)
ALLO : KWG61_04435 KWG61_04440
FIT : Fi14EGH31_23160(nnr)
SCR : SCHRY_v1c06620(yxkO)
SSYR : SSYRP_v1c06840(yxkO)
PCAT : Pcatena_14910(yjeF)
MMAE : MMARE11_10750 MMARE11_42880
MLI : MULP_01249 MULP_04690
MPSE : MPSD_12580 MPSD_46210
MSHO : MSHO_02660 MSHO_29450
MKN : MKAN_01345 MKAN_20145
MXE : MYXE_38720 MYXE_38730
MBAI : MB901379_00982(nnr)
MHEK : JMUB5695_03799(nnr)
MOT : LTS72_09720 LTS72_20065
MMEH : M5I08_01650 M5I08_08080
MKY : IWGMT90018_11120(nnr)
MPHL : MPHLCCUG_01427(nnr)
MAUU : NCTC10437_01202(nnr)
MFLV : NCTC10271_04016(nnr)
MSAL : DSM43276_03536(nnr)
CDIP : ERS451417_02329(nnr)
CHN : A605_07765 A605_13610
CMIN : NCTC10288_00109(nnr)
CCYS : SAMEA4530656_2732(nnr)
CAQM : CAQUA_11060(nnr1) CAQUA_11130(nnr2)
NFR : ERS450000_01930(nnr_1) ERS450000_03236(nnr_2)
NCY : NOCYR_0931 NOCYR_5036
NNO : NONO_c10080 NONO_c59670
NAD : NCTC11293_01699(nnr)
RCR : NCTC10994_03776(nnr)
SLE : sle_29240(sle_29240)
SXT : KPP03845_104537(nnr)
CMH : VO01_05590 VO01_08935
CCAP : AES38_06255 AES38_09385
CZH : H9X71_06295 H9X71_09700
RTX : TI83_04830 TI83_08465
RTC : APU90_01645 APU90_08615
RTN : A6122_1076 A6122_1871
RRY : C1O28_04665 C1O28_08880
CUB : BJK06_01090 BJK06_10280
FRP : AX769_15120 AX769_19615
AMAU : DSM26151_09730(carKD) DSM26151_27450(nnr)
CPHY : B5808_07205 B5808_10585
MALK : MalAC0309_1898(nnrD)
CHRE : IE160_04260 IE160_07240
HUM : DVJ78_10360 DVJ78_13685
HEA : HL652_05535 HL652_09355
FRN : F1C15_12880 F1C15_15035
PSEV : USB125703_01544(nnr)
AAGI : NCTC2676_1_02268(nnr)
DCO : SAMEA4475696_2142(nnr)
PAUS : NCTC13651_00809(nnr)
NDK : I601_1968(nnr_1) I601_3191(nnr_2)
NAQU : ENKNEFLB_01114(nnr)
ACTW : F7P10_13050 F7P10_25350
SACG : FDZ84_08650 FDZ84_11665
PSEE : FRP1_02040 FRP1_02775
PSEQ : AD006_09660 AD006_10390
PECQ : AD017_17490 AD017_18220
ACAD : UA74_15785 UA74_27985
TBW : NCTC13354_00501(nnr)
AHW : NCTC11636_01078(nnr)
AIR : NCTC12972_01396(nnr)
ASLA : NCTC11923_01084(nnr)
AVC : NCTC10951_02939(nnr)
BALA : DSM104299_04320(nnr)
SBAE : DSM104329_04095(nnr)
SYY : SYNGTS_1736(sll1433)
SYT : SYNGTI_1736(sll1433)
SYS : SYNPCCN_1735(sll1433)
SYQ : SYNPCCP_1735(sll1433)
LET : O77CONTIG1_02595(nnr)
SYP : SYNPCC7002_A0648(yjeF)
SYNN : NIES970_00810(yjeF)
NSPH : BDGGKGIB_03840(nnr)
DLY : Dehly_0243 Dehly_0249
CAP : CLDAP_03620 CLDAP_04520
TBH : Tbon_10325 Tbon_12595
TFLA : O0235_02530 O0235_14725
RML : FF011L_11630(nnr_1) FF011L_39910
LCRE : Pla8534_61150(nnr_2)
BREM : PSR63_01675 PSR63_02520
RLC : K227x_08990 K227x_47690(nnr_2)
LLH : I41_44890(nnr_1) I41_50840
AMUC : Pan181_05330(nnr_1)
AMOB : HG15A2_39880(nnr_1) HG15A2_40340
PLON : Pla110_39110(nnr_1)
BROC : IPI25_01160 IPI25_03045
HBS : IPV69_22590 IPV69_25275
TRC : DYE49_00665 DYE49_12225
LHG : JMUB5056_1117 JMUB5056_1118
BTHO : Btheta7330_03716(nnr)
BCEL : BcellWH2_04158(nnr)
PCRE : NCTC12858_00269(nnr)
PCAG : NCTC12856_00816(nnr)
POC : NCTC13071_02332(nnr)
SDJ : NCTC13534_01992 NCTC13534_01993(nnr_1)
STHA : NCTC11429_04962(nnr)
AALG : AREALGSMS7_02876(nnr)
KOS : KORDIASMS9_04256(nnr)
CGLE : NCTC11432_05311(nnr)
CTAI : NCTC12078_01147(nnr)
CJG : NCTC13459_03113(nnr)
CANT : NCTC13489_02929(nnr)
PTAN : CRYO30217_01964(nnr)
SALI : L593_02830 L593_03730
HSIN : KDQ40_04595 KDQ40_17780
HALL : LC1Hm_1762(nnr2) LC1Hm_3050(nnrE)
HSN : DV733_02640 DV733_10605
HLS : KU306_05310 KU306_11560
HAQ : DU484_12355 DU484_15850
HRA : EI982_03535 EI982_16415
HLM : DV707_09825 DV707_11305
HALB : EKH57_03595 EKH57_03980
HSAI : HPS36_14055 HPS36_15180
SRUB : C2R22_08790 C2R22_19570
HDF : AArcSl_1944 AArcSl_2352(nnr)
HAH : Halar_1038 Halar_3033
NAS : GCU68_00555 GCU68_19605
TVO : TVG0137051(TVG0137051)
NUE : C5F50_02335 C5F50_10590
» show all
Taxonomy
Reference
Authors
Marbaix AY, Noel G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL
Title
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.1.99.6
ExPASy - ENZYME nomenclature database: 5.1.99.6