Entry
Name
zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase
Class
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
Reaction(IUBMB)
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN:
R09655 ]
Reaction(KEGG)
Substrate
9,15,9'-tricis-zeta-carotene [CPD:
C19764 ]
Product
9,9'-dicis-zeta-carotene [CPD:
C15857 ]
Comment
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
History
EC 5.2.1.12 created 2011
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K15744 zeta-carotene isomerase
Genes
CSAT : 104739709 104755305 104769441
HSYR : 120191105 120218540
TPRA : 123909631 123914250
PSAT : 127083136 127108130
VVO : 131603465 131607947 131661549 131661564
LJA : Lj4g3v2573880.1(Lj4g3v2573880.1)
LANG : 109326097 109344119
SSPL : 121802201 121808397
SMIL : 130997813 130997979
APAN : 127242650 127264297
ATRI : 130806995 130811322
PSOM : 113283997 113315667
DOSA : Os12t0405200-01(Os12g0405200)
TAES : 123102131 123110269 123119310
PVIR : 120666062 120699317
SMO : SELMODRAFT_13999 SELMODRAFT_157819
FCY : FRACYDRAFT_291550(Z-ISO)
EHX : EMIHUDRAFT_458464 EMIHUDRAFT_463302(AMT17)
SYY : SYNGTS_0427(slr1599)
SYT : SYNGTI_0427(slr1599)
SYS : SYNPCCN_0427(slr1599)
SYQ : SYNPCCP_0427(slr1599)
SYNW : SynWH8103_02598(Z-ISO)
» show all
Taxonomy
Reference
Authors
Chen Y, Li F, Wurtzel ET
Title
Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants.
Journal
Sequence
Reference
Authors
Li F, Murillo C, Wurtzel ET
Title
Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization.
Journal
Sequence
Reference
Authors
Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET
Title
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.2.1.12
ExPASy - ENZYME nomenclature database: 5.2.1.12