Entry Name TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming);
Class Isomerases;BRITE hierarchy
Sysname dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase
Reaction(IUBMB) dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [RN:
R09904 ]
Reaction(KEGG) Substrate dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:
C11907 ]
Product dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [CPD:
C19960 ]
Comment The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. Four moieties of alpha-D-rhamnose and two moities of 3-acetamido-3,6-dideoxy-alpha-D-galactose form the repeating unit of the glycan chain in the S-layer of the bacterium Aneurinibacillus thermoaerophilus.
History EC 5.3.2.3 created 2011
Pathway ec00523 Polyketide sugar unit biosynthesis
ec00541 O-Antigen nucleotide sugar biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K20679 TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Reference Authors Pfoestl A, Hofinger A, Kosma P, Messner P
Title Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
Journal Sequence Reference Authors Davis ML, Thoden JB, Holden HM
Title The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 5.3.2.3
ExPASy - ENZYME nomenclature database: 5.3.2.3
BRENDA, the Enzyme Database: 5.3.2.3
