KEGG ENZYME: 5.3.2.5

ENZYME: 5.3.2.5

Entry

EC 5.3.2.5                  Enzyme

Name

2,3-diketo-5-methylthiopentyl-1-phosphate enolase;
DK-MTP-1-P enolase;
MtnW;
YkrW;
RuBisCO-like protein;
RLP;
2,3-diketo-5-methylthiopentyl-1-phosphate keto---enol-isomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups

Sysname

5-(methylsulfanyl)-2,3-dioxopentyl phosphate keto---enol-isomerase

Reaction(IUBMB)

5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate [RN:R07393]

Reaction(KEGG)

R07393

Substrate

5-(methylsulfanyl)-2,3-dioxopentyl phosphate [CPD:C15650]

Product

2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate [CPD:C15651]

Comment

The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2].In some species a single bifunctional enzyme, EC 3.1.3.77, acireductone synthase, catalyses both this reaction and EC 3.1.3.87, 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [1].

History

EC 5.3.2.5 created 2012

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K08965

2,3-diketo-5-methylthiopentyl-1-phosphate enolase

Genes

ACII:

C4901_00435

ATY:	A9R16_000375

AFR:	AFE_0434(ccbL2)

AFE:	Lferr_0596

ACU:

Atc_2430

ACZ:	Acaty_c2269

AFI:	Acife_0637

AFJ:	AFERRID_16700

ATX:	GCD22_00526(mtnW)

AFP:	K1Y48_02540

PIJ:	QEJ31_10825

SAQI:

AXG55_03435

BSU:	BSU13590(mtnW)

BSR:	I33_1530(mtnW)

BSL:

A7A1_1503

BSH:	BSU6051_13590(mtnW)

BSY:	I653_06975(mtnW)

BSUT:

BSUB_01479(mtnW)

BSUL:

BSUA_01479(mtnW)

BSUS:

Q433_07770(mtnW)

BSO:	BSNT_07850(mtnW)

BSN:	BSn5_18840(mtnW)

BSQ:	B657_13590(mtnW)

BSX:	C663_1400(mtnW)

BSP:	U712_07110

BSS:	BSUW23_06980(mtnW)

BST:	GYO_1686(mtnW)

BIT:	BIS30_17595(mtnW)

BLI:	BL03540(mtnW)

BLD:	BLi01515(mtnW)

BLH:	BaLi_c15940(mtnW)

BAY:	RBAM_013370(mtnW)

BAQ:	BACAU_1314(mtnW)

BYA:	BANAU_1273(mtnW)

BAMP:

B938_06955(mtnW)

BQY:	MUS_1440(mtnW)

BAML:

BAM5036_1273(mtnW)

BAMA:

RBAU_1315(mtnW)

BAMN:

BASU_1294(mtnW)

BAMB:

BAPNAU_2426(mtnW)

BAMT:

AJ82_07680(mtnW)

BAMY:

V529_12890(mtnW)

BMP:	NG74_01393(mtnW)

BAO:	BAMF_1441(mtnW)

BAZ:	BAMTA208_10340(mtnW)

BQL:	LL3_01461(mtnW)

BXH:	BAXH7_02114(mtnW)

BAMI:

KSO_012680(mtnW)

BAMC:

U471_13600

BAMF:

U722_07145(mtnW)

BSIA:

CWD84_14565(mtnW)

BAE:	BATR1942_04550(mtnW)

BVM:	B9C48_06840

BSON:

S101395_03400(mtnW)

BHT:	DIC78_02645(mtnW)

BMOJ:

HC660_14280(mtnW)

BTEQ:

G4P54_07130(mtnW)

BIQ:	AN935_07085(mtnW)

BSTR:

QI003_07340(mtnW)

BAN:	BA_4255(mtnW)

BAR:	GBAA_4255(mtnW)

BAT:

BAS3946

BAH:	BAMEG_4296(mtnW)

BAI:	BAA_4278(mtnW)

BAX:	H9401_4055

BANT:

A16_42560

BANR:

A16R_43100

BANS:

BAPAT_4080

BANH:

HYU01_20790(mtnW)

BANV:

DJ46_2947(mtnW)

BCE:

BC4036

BCA:

BCE_4103

BCZ:	BCE33L3793(rbcL)

BCR:	BCAH187_A4167(mtnW)

BCB:	BCB4264_A4145(mtnW)

BCU:	BCAH820_4057(mtnW)

BCG:	BCG9842_B1093(mtnW)

BCQ:	BCQ_3826(rbcL)

BCX:	BCA_4149(mtnW)

BAL:	BACI_c40050

BNC:

BCN_3948

BCF:

bcf_20075

BCER:

BCK_15020(mtnW)

BCEF:

BcrFT9_03150

BCY:	Bcer98_2735

BTK:	BT9727_3778(rbcL)

BTL:

BALH_3653

BTB:	BMB171_C3700(mtnW)

BTT:

HD73_4335

BTHR:

YBT1520_21490(mtnW)

BTHI:

BTK_21340(mtnW)

BTC:	CT43_CH4042(mtnW)

BTF:	YBT020_19870(mtnW)

BTM:	MC28_3328(mtnW)

BTG:	BTB_c41710(mtnW)

BTI:	BTG_29240(mtnW)

BTN:	BTF1_18495(mtnW)

BTHT:

H175_ch4108

BTHU:

YBT1518_22360(mtnW)

BTW:	BF38_5209(mtnW)

BTHY:

AQ980_09670(mtnW)

BWE:	BcerKBAB4_3865

BWW:	bwei_0915(mtnW)

BMYO:

BG05_1986(mtnW)

BTY:	Btoyo_1281

BMYC:

DJ92_1131(mtnW)

BBY:	CY96_19270(mtnW)

BWD:	CT694_21720(mtnW)

BTRO:

FJR70_13925(mtnW)

BMOB:

MLA2C4_21110(mtnW)

BNT:	GSN03_19125(mtnW)

BPAC:

LMD38_06905(mtnW)

BPAN:

NLJ82_19615(mtnW)

BALU:

QRY64_23095(mtnW)

BPU:	BPUM_1252(mtnW)

BPUM:

BW16_07065(mtnW)

BPUS:

UP12_06570(mtnW)

BIF:	N288_08395(mtnW)

BMET:

BMMGA3_05045(mtnW)

BSM:	BSM4216_3456

BGY:	BGLY_1452(mtnW)

BWH:	A9C19_12800

BXI:	BK049_01795

BALT:

CFN77_06935(mtnW)

BAER:

BAE_14150(mtnW)

BSAF:

BSL056_06540

BBAD:

K7T73_02620

BCAB:

EFK13_07590(mtnW)

BRY:	M0696_07435(mtnW)

BJS:

MY9_1488

GST:	HW35_15685(mtnW)

BACW:

QR42_06425(mtnW)

BACP:

SB24_03030(mtnW)

BACB:

OY17_09780(mtnW)

BACY:

QF06_05805(mtnW)

BACL:

BS34A_15100(mtnW)

BALM:

BsLM_1440

BACS:

AUL54_03855(mtnW)

BACQ:

DOE78_07025

BZH:	NF868_05800(mtnW)

BHAI:

KJK41_08105

BARD:

QRY57_19965(mtnW)

BAEI:

RE735_13105(mtnW)

BHK:	B4U37_07785

BCOH:

BC6307_09130

BMQ:	BMQ_1250(mtnW)

BMD:	BMD_1234(mtnW)

BMH:	BMWSH_3986(mtnW)

BMEG:

BG04_3549(mtnW)

BEO:

BEH_04815

BFX:	BC359_14805

PKS:	IE339_04950(mtnW)

BKW:	BkAM31D_06395(mtnW)

BCL:	ABC1775(mtnW)

BLE:	BleG1_0631 BleG1_1589

SHUA:

PQ477_11630 PQ477_16795

BGI:	BGM20_01135

BPF:	BpOF4_14675(mtnW)

BON:	A361_08445(mtnW)

BKO:	CKF48_04400

CGOT:

J1899_12690

CSUA:

IM538_06115(mtnW)

CFIR:

NAF01_07950

GKA:

GK0953

GTE:	GTCCBUS3UF5_11270

GTK:	GT3570_04590(mtnW)

GTM:	GT3921_14695

GLI:	GLN3_15045

BCAL:

CWI35_05370(mtnW)

GTN:

GTNG_0841

GWC:	GWCH70_0850

GYC:	GYMC61_1745

GYA:	GYMC52_0871

GCT:	GC56T3_2602

GMC:	GY4MC1_2913

GGH:	GHH_c08900(mtnW)

GJF:	M493_04885(mtnW)

GEA:	GARCT_00965(mtnW)

GSE:	GT50_14450(mtnW)

GSR:	GS3922_11660(mtnW)

GEJ:	A0V43_02065(mtnW)

GZA:	IC807_00530(mtnW)

PTL:	AOT13_07930(mtnW)

PTB:	DER53_08875(mtnW)

PCAL:

BV455_00903(mtnW)

PARG:

PspKH34_28400(mtnW)

AFL:

Aflv_1997

AGN:	AFK25_04400(mtnW)

ANM:	GFC28_1480(mtnW)

AAMY:

GFC30_1262(mtnW)

ANL:	GFC29_148(mtnW)

AND:	GRQ40_05510(mtnW)

ACAI:

ISX45_02035(mtnW)

ASED:

IRT44_02480

FPN:	ABE65_007245(mtnW)

FAR:	ABE41_008290

FEC:	QNH15_09580(mtnW)

APAK:

AP3564_01620

ACOP:

RI196_15870

BSJ:	UP17_14160(mtnW)

BMUR:

ABE28_013145

PBUT:

DTO10_01370(mtnW)

PFRI:

L8956_14710(mtnW)

PSYO:

PB01_20415(mtnW)

PSYB:

KD050_10515(mtnW)

NTM:	BTDUT50_06095(mtnW)

NCM:	QNK12_07985(mtnW)

NNV:	QNH39_08605(mtnW)

MEKU:

HUW50_18085(mtnW)

MSEM:

GMB29_14935(mtnW)

MDG:	K8L98_09000(mtnW)

MLIT:

KDJ21_023015(mtnW)

BVQ:	FHE72_08645

RMF:	D5E69_09030

RAZ:	U9J35_08690

MCUI:

G8O30_03760

GAJ:	MY490_13400

PSUA:

FLK61_24150

MJO:	FOF60_07540(mtnW)

MSUT:

LC048_14405(mtnW)

ECTO:

MUG87_06845(mtnW)

ALKL:

MM271_01220

PHJ:	LC071_15820

DOM:	RRU94_12685

MACR:

BHM04_11610

MBRU:

MGG13_10480

MEPI:

KFV12_12355

MEQU:

KFV11_01855

MBOC:

QSV55_10640

MCAK:

MCCS_23710(mtnW)

MBOE:

HT586_11470

ESI:

Exig_0430

EAT:	EAT1b_1436

EAN:	Eab7_0405(mtnW)

EXM:	U719_02210(mtnW)

EXU:	ESP131_04655

EAP:	KB235_03365

EACE:

KKI46_02470

EAUR:

NMQ00_01800

EPF:	OE059_01655

BBE:	BBR47_48900(mtnW)

BLR:	BRLA_c041920

BFM:	BP422_20265

BAGR:

BA6348_07050

BRW:	GOP56_13485

BCHS:

JNE38_26585

BCOP:

JD108_04270

BPAB:

PSE45_23295

BHUI:

LOK74_17080

BAYD:

BSPP4475_03375

BBOR:

RFB14_04495

BRUM:

NDK47_05355

PJD:	Pjdr2_2465

GYM:	GYMC10_2267

PPY:	PPE_02689(mtnW)

PPM:	PPSC2_14325(ykrW)

PPO:	PPM_2881(ykrW)

PPOL:

X809_30750(mtnW)

PPQ:	PPSQR21_028520(rbcL)

PPOY:

RE92_22375(mtnW)

PMS:	KNP414_04026(mtnW)

PMQ:	PM3016_5397

PTA:	HPL003_23125(mtnW)

PLV:	ERIC2_c14190(mtnW)

PBJ:	VN24_24480(mtnW)

PIH:	UB51_05770(mtnW)

PPEO:

ABE82_14765(mtnW)

PNP:	IJ22_10280

POW:	IJ21_24230

PBV:	AR543_16260

PXL:	BS614_22280

PSWU:

SY83_18315(mtnW)

PIB:	BBD41_03790

PKB:	B4V02_10810

PAIH:

ASL14_23615(mtnW)

PVO:	PVOR_13854(mtnW)

PLW:	D5F53_18330

PLEN:

EIM92_14625

PPSC:

EHS13_19035

PALB:

EJC50_22025

PCHI:

PC41400_12055

PBK:	Back11_10090(mtnW)

PPRT:

ET464_06640

PBAC:

HUB98_04715

PRZ:	GZH47_28900

PLYC:

GXP70_18720

PALO:

E6C60_1902

PCEL:

HUB94_14295

PALR:

HGI30_10460

PTHI:

NDS46_17550

PKA:	PQ456_13850

PMAH:

PTQ21_25245

PAMY:

P9222_18015

PDY:	QJQ58_04470

PWN:	QNH46_14205

PSPN:

L1F29_20410

PPOG:

QPK24_15995

PAUN:

MJA45_16525

PHK:	SK066_09620

PNK:	AASFL403_05210

PPAB:

KET34_21890

PKP:	SK3146_06389(mtnW)

TCO:	Theco_1802

ANX:	ACH33_15410(mtnW)

ASOC:

CB4_03885(mtnW)

ATHE:

K3F53_03445

COH:	EAV92_08895

CCHL:

FPL14_27115

CHEB:

HH215_04230

AAC:

Aaci_0096

AAD:	TC41_0117(mtnW)

AFX:	JZ786_04785

AACO:

K1I37_01135

ACUR:

JZ785_14605

ADAU:

NZD86_01665

AFAS:

NZD89_01225

ACYC:

JI721_06995

TUM:	CBW65_12825

TAB:	CIG75_15780

EFF:	skT53_15370(mtnW)

PANA:

BBH88_03600

PDG:	BCM40_00535

PHC:	BBI08_11895

PMAR:

B0X71_16600

PPLA:

BBI15_12965

PLX:	CW734_02320

PGQ:	FK545_06705(mtnW)

JEO:

JMA_33120

SURE:

SporoP32a_07290(mtnW)

SPOS:

DV702_00170

PANC:

E2636_08755

PLAY:

DNR44_004080(mtnW)

LFB:	C1X05_12315

TVU:	AB849_002715

PABS:

JIR001_28090(mtnW)

SAY:	TPY_2539(mtnW)

SAP:	Sulac_3291

ACIT:

HPK19_08185

MAR:

MAE_13070

MPK:

VL20_1894

MIQ:	B5D77_03275

MVZ:	myaer102_47140

CYP:	PCC8801_2072

CYH:	Cyan8802_2096

CYC:	PCC7424_0958

CYJ:	Cyan7822_0549

ARP:	NIES39_E02120

PAGH:

NIES204_31820

PPSU:

NO713_00127(mtnW)

PRUN:

PCC7821_03269(mtnW)

LFS:	HFV01_23775

MPRO:

BJP34_01135

MIC:	Mic7113_2203

GEI:	GEI7407_0620

CALT:

Cal6303_1394

CALS:

NIES3974_38130

RIV:	Riv7116_5245

PLP:	Ple7327_0641

SCS:	Sta7437_1268

STAN:

STA3757_37710

PMX:	PERMA_0408

LFC:

LFE_0827

LFI:	LFML04_2084

LFP:	Y981_10670

LEG:	ABH19_11250

MOX:	DAMO_2930(mtnW)

» show all

Reference

1 [PMID:8227039]

Authors

Myers RW, Wray JW, Fish S, Abeles RH.

Title

Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae.

Journal

J Biol Chem 268:24785-91 (1993)

Reference

2 [PMID:14551435]

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Sequence

[bsu:BSU13590]