KEGG ENZYME: 5.3.99.10

ENZYME: 5.3.99.10

Entry

EC 5.3.99.10                Enzyme

Name

thiazole tautomerase;
tenI (gene name)

Class

Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases

Sysname

2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase

Reaction(IUBMB)

2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [RN:R09977]

Reaction(KEGG)

R09977

Substrate

2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate [CPD:C20246]

Product

2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [CPD:C20247]

Comment

The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.

History

EC 5.3.99.10 created 2012

Pathway

ec00730

Thiamine metabolism

ec01100

Metabolic pathways

Orthology

K10810

thiazole tautomerase (transcriptional regulator TenI)

Genes

IGN:	MMG00_09085

WCN:	PE074_01940

SDO:	SD1155_02250

CRX:	CRECT_1046

APOC:

APORC_0157

BSU:	BSU11660(tenI)

BSR:

I33_1300

BSL:

A7A1_0983

BSH:	BSU6051_11660(tenI)

BSY:	I653_05925

BSUT:

BSUB_01268(tenI)

BSUL:

BSUA_01268(tenI)

BSUS:

Q433_06590

BSO:	BSNT_07609(tenI)

BSN:	BSn5_17745

BSQ:	B657_11660(tenI)

BSX:	C663_1194(tenI)

BSP:	U712_06000

BSS:	BSUW23_05895(tenI)

BST:

GYO_1471

BLI:	BL01591(tenI)

BLD:	BLi01260(tenI)

BLH:	BaLi_c13950(tenI)

BAY:	RBAM_011670(tenI)

BAQ:	BACAU_1128(tenI)

BYA:	BANAU_1073(tenI)

BAMP:

B938_05675

BQY:	MUS_1211(tenI)

BAML:

BAM5036_1067(tenI)

BAMA:

RBAU_1129(tenI)

BAMN:

BASU_1106(tenI)

BAMB:

BAPNAU_2628(tenI)

BAMT:

AJ82_06560

BAMY:

V529_11150(tenI)

BMP:	NG74_01181(tenI)

BAO:	BAMF_1240(tenI)

BAZ:	BAMTA208_11770(tenI)

BQL:	LL3_01247(tenI)

BXH:	BAXH7_02403(tenI)

BAMI:

KSO_014005

BAMC:

U471_11640

BAMF:

U722_05950

BSIA:

CWD84_15905

BAE:	BATR1942_03475

BVM:	B9C48_05865

BSON:

S101395_03589(tenI)

BHT:	DIC78_03745

BMOJ:

HC660_12240(tenI)

BTEQ:

G4P54_06135(tenI)

BIQ:	AN935_06055

BSTR:

QI003_06285(tenI)

BAN:	BA_0729(tenI)

BAR:	GBAA_0729(tenI)

BAT:

BAS0695

BAH:	BAMEG_3830(tenI)

BAI:	BAA_0836(tenI)

BAX:	H9401_0698

BANT:

A16_08140

BANR:

A16R_08220

BANS:

BAPAT_0705

BANH:

HYU01_04015

BANV:

DJ46_5209(tenI)

BCE:

BC0746

BCA:	BCE_0799(tenI)

BCZ:	BCE33L0639(thiE)

BCR:	BCAH187_A0883(tenI)

BCB:	BCB4264_A0786(tenI)

BCU:	BCAH820_0806(tenI)

BCG:	BCG9842_B4545(tenI)

BCQ:	BCQ_0820(tenI)

BCX:	BCA_0792(tenI)

BAL:	BACI_c07600(thiE2)

BNC:

BCN_0707

BCF:

bcf_03845

BCER:

BCK_04490

BCEF:

BcrFT9_00678

BCY:	Bcer98_0616

BTK:	BT9727_0639(thiE)

BTL:

BALH_0666

BTB:	BMB171_C0639(tenI)

BTT:

HD73_0864

BTHR:

YBT1520_04280

BTHI:

BTK_04255 BTK_04305

BTC:	CT43_CH0707(tenI)

BTF:	YBT020_03925

BTM:

MC28_0009

BTG:	BTB_c08220(tenI)

BTI:

BTG_17490

BTN:	BTF1_01360

BTHT:

H175_ch0713

BTHU:

YBT1518_04660

BTW:	BF38_1996(tenI)

BTHY:

AQ980_26570

BWE:	BcerKBAB4_0645

BWW:	bwei_4260(tenI)

BMYO:

BG05_5172(tenI)

BTY:	Btoyo_3427

BMYC:

DJ92_3340(tenI)

BBY:	CY96_02900

BWD:	CT694_04180

BTRO:

FJR70_26055(tenI)

BMOB:

MLA2C4_03940

BNT:	GSN03_04070(tenI)

BPAC:

LMD38_22290(tenI)

BPAN:

NLJ82_03990(tenI)

BALU:

QRY64_06100(tenI)

BPU:

BPUM_1095

BPUM:

BW16_06215

BPUS:

UP12_05815

BIF:	N288_03125

BMET:

BMMGA3_01095

BSM:	BSM4216_0680

BGY:

BGLY_1279

BWH:	A9C19_14775

BXI:	BK049_02420

BALT:

CFN77_05815(tenI)

BAER:

BAE_13405

BSAF:

BSL056_05755

BFD:	NCTC4823_00320(tenI)

BSHI:

LGQ02_16070(tenI)

BBAD:

K7T73_07480(thiS)

BCAB:

EFK13_06510(tenI)

BRY:	M0696_06425(tenI)

BJS:

MY9_1271

BACI:

B1NLA3E_07765

GST:	HW35_12450

BACW:

QR42_05650

BACP:

SB24_04035

BACB:

OY17_08535

BACO:

OXB_0158

BACY:

QF06_04780

BACL:

BS34A_12890(tenI)

BALM:

BsLM_1220

BACS:

AUL54_04795

BACQ:

DOE78_13040

BACA:

FAY30_13915

BAQU:

K6959_06430

BZH:	NF868_05225(tenI)

BHAI:

KJK41_11290

BCAO:

LC087_01685

BARD:

QRY57_05540(tenI)

BAEI:

RE735_13770(tenI)

BCO:	Bcell_0762

BHK:	B4U37_06145

BCOH:

BC6307_03695

BCIR:

C2I06_18805

NTX:	NQZ71_19055

BMQ:

BMQ_0548

BMD:

BMD_0551

BMH:	BMWSH_4685(tenI)

BMEG:

BG04_2840(tenI)

BEO:

BEH_03335

PKS:	IE339_03110(tenI)

BGI:	BGM20_21135

BON:	A361_02660

CGOT:

J1899_01395

CSUA:

IM538_04290(tenI)

CFIR:

NAF01_02700(tenI)

CSPG:

LS684_11160(tenI) LS684_22820

CPSS:

M5V91_19500

OJD:	NP439_02415

GKA:

GK0622

GTE:	GTCCBUS3UF5_6900

GTK:	GT3570_02995

GTM:	GT3921_16485

GLI:	GLN3_13320

BCAL:

CWI35_07080

GTN:	GTNG_0535(tenI)

GWC:	GWCH70_0610

GYC:	GYMC61_1414

GYA:	GYMC52_0535

GCT:	GC56T3_2939

GMC:	GY4MC1_3187

GGH:	GHH_c05750(tenI)

GJF:	M493_03245

GEA:	GARCT_00596(tenI)

GEL:	IB49_13385

GSE:	GT50_12625

GSR:	GS3922_12895

GEJ:	A0V43_00485

GZA:	IC807_16665(tenI)

GTH:	Geoth_3207

PTL:	AOT13_06590

PTB:	DER53_07630(tenI)

PCAL:

BV455_01136(tenI)

PARG:

PspKH34_31160(thiE_2)

AFL:	Aflv_2316(tenI)

AGN:	AFK25_02700

ANM:	GFC28_1935

AAMY:

GFC30_999

ANL:	GFC29_3499

AND:	GRQ40_03575(tenI)

ACAI:

ISX45_00430(tenI)

ASED:

IRT44_15490

LGY:	T479_11215

LAGR:

FJQ98_02345

LLB:	R6U77_16895

HHD:	HBHAL_3422

HMN:	HM131_18590

HLI:

HLI_03130

HNZ:	P9989_01480

HSAN:

MUN89_12760

HSHI:

MUO14_13770

HAMY:

MUO15_12510

TAID:

KS242_01650

VIR:	X953_15625

VHL:	BME96_15105

VIG:	BKP57_16350

VIL:	CFK37_18020

VPN:	A21D_02454(tenI)

VIM:	GWK91_05245(tenI)

VPT:	KBP50_13600

LAO:	AOX59_02240

LEX:	Len3610_08945

FPN:	ABE65_019775

FAR:	ABE41_018785

FEC:	QNH15_05690

SJE:	AAV35_010940

APAK:

AP3564_10210

ACOP:

RI196_05540(tenI)

BSJ:	UP17_10595

BMUR:

ABE28_010665

PBUT:

DTO10_24110

PASA:

BAOM_1979

PFRI:

L8956_11425(tenI)

AQT:	FN924_04405(tenI)

RAX:	KO561_15335(tenI)

GRC:	GI584_17365

GCS:	MUN88_11965

GSM:	MUN87_06895

RUE:	DT065_09400

SALE:

EPH95_09395

SCIB:

HUG20_16625

SCIA:

HUG15_19545

POF:	GS400_16470(tenI)

NMK:	CHR53_16595

NTM:	BTDUT50_04330

NDT:	L1999_10460

NCM:	QNK12_12935

MEKU:

HUW50_13730(tenI)

MSEM:

GMB29_05030

MDG:	K8L98_06020(tenI)

MLIT:

KDJ21_000105

BLEN:

NCTC4824_01712(tenI)

SEDD:

ERJ70_03240(tenI)

BVQ:	FHE72_12275

RMF:	D5E69_12095

RAZ:	U9J35_12420

BBEV:

BBEV_2245(thiE-2)

BSE:

Bsel_2693

GAJ:	MY490_18560

PSUA:

FLK61_23685

SLMS:

MM221_17320

SFOR:

QNH23_17205

ECTO:

MUG87_16235(tenI)

ALKG:

MOJ78_02955(tenI)

DOM:	RRU94_23585

AHAL:

FTX54_005255

PUK:	PU629_02890

SER:

SERP2070

SEP:

SE_2057

SEPP:

SEB_02063

SEPS:

DP17_999

SHA:

SH0565

SHH:	ShL2_00460(tenI)

SSP:

SSPP136

SCA:

SCA_2076

SLG:	SLGD_00498

SLN:	SLUG_04960

SSD:	SPSINT_0375

SDT:

SPSE_2079

SDP:	NCTC12225_02300(tenI)

SWA:	A284_01980

SPAS:

STP1_0997

SXY:	BE24_11340

SXL:	SXYLSMQ121_0150

SXO:	SXYL_00143

SHU:	SHYC_10375(thiE-2)

SCAP:

AYP1020_1664(tenI)

SSCH:

LH95_09890

SSCZ:

RN70_10655

SAGQ:

EP23_11770

SEQO:

SE1039_24290

SSIF:

AL483_11990

SCV:	A4G25_09835

SPET:

CEP67_07450

SLZ:	B5P37_07770

SKL:	C7J89_03105

SFQ:	C7J90_01385

SHOM:

EGX58_06370

SMUS:

C7J88_08780

SCAR:

DWB96_02300

SCHR:

DWB92_10530

SARL:

SAP2_03630

SDB:	CNQ82_03155

SLLO:

ISP08_01920

SAUL:

I6G39_00700

SRAI:

LN051_09660

SPSD:

JMB28_01250

STAS:

HYI43_02635

SEDA:

MNY58_00360

SCAQ:

QMO72_00765

SDEV:

Q2T90_04960

STAP:

AOB58_1960

SSCU:

CEP64_00955

SFF:	FOB90_09560

MLEN:

H3V22_07355

MVT:	I6J10_09695

MACR:

BHM04_09660

MARY:

LAU42_00655

MBRU:

MGG13_00535

MEPI:

KFV12_01275

MCL:	MCCL_0120(thiE)

MCAK:

MCCS_02280(tenI)

MBOE:

HT586_01270

SHV:	AAT16_06160

JEA:	JEM45_07405

SBAC:

BVH56_01230

ESI:

Exig_1198

EAN:

Eab7_1154

EXM:	U719_06140

EXU:	ESP131_08540

EACE:

KKI46_06335

BBE:	BBR47_32230(tenI)

BLR:	BRLA_c028190(tenI)

BFM:	BP422_11250

BAGR:

BA6348_14300

BRW:	GOP56_06640

BCOP:

JD108_10875

BPAB:

PSE45_15250

BHUI:

LOK74_07445(thiE)

BAYD:

BSPP4475_09875

BBOR:

RFB14_12245

BRUM:

NDK47_12910

PPY:

PPE_02543

PPM:	PPSC2_13595(tenI)

PPO:	PPM_2608(tenI)

PPOL:

X809_30000

PPQ:	PPSQR21_027030(thiE)

PPOY:

RE92_23140

PMS:	KNP414_01516

PMW:

B2K_09275

PTA:	HPL003_20225

PLV:	ERIC2_c05510(tenI)

PSAB:

PSAB_08630

PDU:	PDUR_09855

PBD:	PBOR_11700

PGM:	PGRAT_10845

POD:	PODO_09455

PAEA:

R70723_10620

PAEE:

R70331_10290

PAEH:

H70357_11255

PIH:	UB51_13350

PRI:

PRIO_2351

PSON:

JI735_20515

PPEO:

ABE82_14060

PNP:	IJ22_05520

PBV:	AR543_15205

PXL:	BS614_21245

PSWU:

SY83_08625

PDH:	B9T62_05595

PCX:	LPB68_19265

PKB:	B4V02_11455

PCHI:

PC41400_28395

PBAC:

HUB98_03475

PSOP:

KP014_12355

PTRI:

KDC22_10045

PTJ:	JRJ22_08915

PKA:	PQ456_12835

PUI:	PUW25_16130

PMAH:

PTQ21_24210

PAMY:

P9222_19160

PMAE:

LMZ02_26975

PPOG:

QPK24_15490

PAUN:

MJA45_19665

PHK:	SK066_10575

PNK:	AASFL403_06190

PPAB:

KET34_20975

PKP:	SK3146_02082(tenI)

ANX:	ACH33_14270

ASOC:

CB4_03606(tenI)

ATHE:

K3F53_04640

AAD:

TC41_2776

AFX:	JZ786_01830

BTS:

Btus_0498

KYR:	CVV65_03970(thiE)

TAB:	CIG75_15150(thiE)

PANA:

BBH88_04720

JEO:

JMA_36340

KUR:	ASO14_1578

SPSY:

AZE41_02025

SURE:

SporoP32a_10790

SPOS:

DV702_14940

SPAE:

E2C16_14630

SURL:

BI350_02470

RST:	ATY39_11670

PANC:

E2636_03665(tenI)

UTH:	DKZ56_01460(tenI)

NTR:	B0W44_17370

LFB:	C1X05_11810

TVU:	AB849_008970

KPUL:

GXN76_10825

KEB:	GXN75_12165

PABS:

JIR001_21600(thiE_2)

CNO:	NT01CX_1504

CBE:

Cbei_0648

CBZ:

Cbs_0648

CBEI:

LF65_00721

CSR:	Cspa_c48990(thiE2)

CPAS:

Clopa_4119

CPAT:

CLPA_c33340(thiE2)

CPAE:

CPAST_c33340(thiE2)

CSB:	CLSA_c25120

CLT:	CM240_2379

CACE:

CACET_c37710(thiE2)

CBUT:

ATN24_11570

CEU:	A7L45_01995

CDY:	F3K33_03670

RUJ:	E5Z56_11415

ELM:

ELI_0854

EMT:	CPZ25_017210

ELIM:

B2M23_11970

SAY:

TPY_3618

SAP:	Sulac_1301

STHR:

BXT84_15515

CCT:

CC1_29720

ARF:	AR1Y2_1227

ACAC:

EYQ97_11215

VGU:	HYG85_03345

MDV:	C5Q96_03425

EAC:	EAL2_c00370(tenI)

LPIL:

LIP_0284

ACIT:

HPK19_14065

TRO:	trd_0401(thiE)

STI:

Sthe_1493

TAZ:	TREAZ_2037

DDF:	DEFDS_2135

DAP:	Dacet_2766

MEAR:

Mpt1_c00770(thiE1) Mpt1_c03060(thiE2)

» show all

Reference

1 [PMID:21534620]

Authors

Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP

Title

A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase.

Journal

J Am Chem Soc 133:9311-9 (2011)
DOI:10.1021/ja1110514

Sequence

[bsu:BSU11660]

Other DBs

ExplorEnz - The Enzyme Database:

5.3.99.10

IUBMB Enzyme Nomenclature:

5.3.99.10

ExPASy - ENZYME nomenclature database:

5.3.99.10

BRENDA, the Enzyme Database:

5.3.99.10

DBGET integrated database retrieval system