Entry
Name
cucurbitadienol synthase;
CPQ (gene name);
(S)-2,3-epoxysqualene mutase (cyclizing, cucurbitadienol-forming)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, cucurbitadienol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = cucurbitadienol [RN:
R09688 ]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:
C01054 ]
Product
History
EC 5.4.99.33 created 2011
Pathway
ec00909 Sesquiterpenoid and triterpenoid biosynthesis
ec00996 Biosynthesis of various alkaloids
ec01110 Biosynthesis of secondary metabolites
Orthology
K15812 cucurbitadienol synthase
Genes
Taxonomy
Reference
1
Authors
Shibuya, M., Adachi, S., and Ebizuka, Y.
Title
Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis.
Journal
Tetrahedron 60:6995-7003 (2004)
Other DBs
ExPASy - ENZYME nomenclature database: 5.4.99.33