KEGG   ENZYME: 5.4.99.33
Entry
EC 5.4.99.33                Enzyme                                 
Name
cucurbitadienol synthase;
CPQ (gene name);
(S)-2,3-epoxysqualene mutase (cyclizing, cucurbitadienol-forming)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, cucurbitadienol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = cucurbitadienol [RN:R09688]
Reaction(KEGG)
R09688
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
cucurbitadienol [CPD:C19819]
History
EC 5.4.99.33 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec00996  Biosynthesis of various alkaloids
ec01110  Biosynthesis of secondary metabolites
Orthology
K15812  cucurbitadienol synthase
Genes
CSV101204533
CMO103498907
BHJ120068021
MCHA111017486
CMAX111488502
CMOS111455830
CPEP111807422
Reference
1
  Authors
Shibuya, M., Adachi, S., and Ebizuka, Y.
  Title
Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis.
  Journal
Tetrahedron 60:6995-7003 (2004)
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.33
IUBMB Enzyme Nomenclature: 5.4.99.33
ExPASy - ENZYME nomenclature database: 5.4.99.33
BRENDA, the Enzyme Database: 5.4.99.33

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