KEGG ENZYME: 5.4.99.40

ENZYME: 5.4.99.40

Entry

EC 5.4.99.40                Enzyme

Name

alpha-amyrin synthase;
2,3-oxidosqualene alpha-amyrin cyclase;
mixed amyrin synthase

Class

Isomerases;
Intramolecular transferases;
Transferring other groups

Sysname

(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming)

Reaction(IUBMB)

(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin [RN:R06471]

Reaction(KEGG)

R06471

Substrate

(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]

Product

alpha-amyrin [CPD:C08615]

Comment

A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase).

History

EC 5.4.99.40 created 2011

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K15815

lupeol synthase 2

K20658

alpha/beta-amyrin synthase

K21928

delta/alpha/beta-amyrin synthase

Genes

ATH:	AT1G78960(LUP2)

CRB:	17894179 17894180

EUS:	EUTSA_v10018166mg EUTSA_v10022563mg

BRP:	103830506 103832374

BNA:

106354658

TPRA:

123885848

CAM:

101509140

PSAT:

127076375 127076377

VVO:	131616260 131616262 131623342 131623344

PDUL:

117620888

SLY:	100529100(TTS2)

SOT:

102591877

SSTN:

125852109

» show all

Reference

1 [PMID:10848960]

Authors

Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y

Title

Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase.

Journal

Eur J Biochem 267:3453-60 (2000)
DOI:10.1046/j.1432-1327.2000.01357.x

Sequence

[ag:BAA97559]

Other DBs

ExplorEnz - The Enzyme Database:

5.4.99.40

IUBMB Enzyme Nomenclature:

5.4.99.40

ExPASy - ENZYME nomenclature database:

5.4.99.40

BRENDA, the Enzyme Database:

5.4.99.40

DBGET integrated database retrieval system