KEGG   ENZYME: 5.4.99.54
Entry
EC 5.4.99.54                Enzyme                                 
Name
beta-seco-amyrin synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-seco-amyrin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-seco-amyrin [RN:R09914]
Reaction(KEGG)
R09914
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
beta-seco-amyrin [CPD:C20193]
Comment
The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin. See EC 5.4.99.52, alpha-seco-amyrin synthase.
History
EC 5.4.99.54 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K16204  seco-amyrin synthase
Genes
ATH: AT1G78500
BRP: 103842460
BNA: 106369564
BOE: 106310247
THJ: 104809000
Reference
1  [PMID:17263431]
  Authors
Shibuya M, Xiang T, Katsube Y, Otsuka M, Zhang H, Ebizuka Y
  Title
Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase.
  Journal
J Am Chem Soc 129:1450-5 (2007)
DOI:10.1021/ja066873w
  Sequence
[ath:AT1G78500]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.54
IUBMB Enzyme Nomenclature: 5.4.99.54
ExPASy - ENZYME nomenclature database: 5.4.99.54
BRENDA, the Enzyme Database: 5.4.99.54

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (5)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (19)   

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