 | | ENZYME: 5.4.99.7 | |
| Entry |
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| Name |
lanosterol synthase;
2,3-epoxysqualene lanosterol cyclase;
squalene-2,3-oxide-lanosterol cyclase;
lanosterol 2,3-oxidosqualene cyclase;
squalene 2,3-epoxide:lanosterol cyclase;
2,3-oxidosqualene sterol cyclase;
oxidosqualene cyclase;
2,3-oxidosqualene cyclase;
2,3-oxidosqualene-lanosterol cyclase;
oxidosqualene-lanosterol cyclase;
squalene epoxidase-cyclase;
(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
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| Class |
Isomerases;
Intramolecular transferases;
Transferring other groups
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| Sysname |
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lanosterol-forming)
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| Reaction(IUBMB) |
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol [RN: R03199]
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| Reaction(KEGG) |
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| Substrate |
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD: C01054]
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| Product |
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| History |
EC 5.4.99.7 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 5.4.99.7 rest to EC 1.14.99.7
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
| MRV: | 120374232 120374242 120374980 |
| SUND: | 121919889(LSS) 121928990 |
| PMUR: | 107294412 107296168(LSS) |
| CTIG: | 120297402 120300363(LSS) |
| PGUT: | 117659519 117664346 117671165(LSS) |
| PTEX: | 113440660 113440982(LSS) |
| NSS: | 113410919 113419569(LSS) |
| PMUA: | 114582271(LSS) 114598445 114598953 |
| PRAF: | 128400306(LSS) 128415723 128415724 |
| ZVI: | 118079446 118097047(LSS) |
| BBUF: | 121008548 121008549 |
| BGAR: | 122944874 122945066 |
| SANH: | 107660663 107673746 |
| RKG: | 130096623(lss) 130096625 |
| PGEO: | 117466554 117466555 |
| MSAM: | 119903407(lss) 119903566 |
| OLA: | 101157258 101157497(lss) |
| KMR: | 108247360 108247361 108247362 |
| ALIM: | 106529310(lss) 106529311 |
| NWH: | 119418993 119418994 119419509 119419797 |
| MCEP: | 125017960 125017961 |
| PMEO: | 129587495 129587496 |
| PVIR: | 120640014 120645568 |
| NCS: | NCAS_0H01640(NCAS0H01640) |
| NDI: | NDAI_0C01970(NDAI0C01970) |
| TPF: | TPHA_0E01120(TPHA0E01120) |
| TBL: | TBLA_0A03120(TBLA0A03120) |
| TDL: | TDEL_0E02760(TDEL0E02760) |
| KAF: | KAFR_0D04670(KAFR0D04670) |
| KNG: | KNAG_0B04580(KNAG0B04580) |
| CAL: | CAALFM_C202460WA(ERG7) |
| NTE: | NEUTE1DRAFT127722(NEUTE1DRAFT_127722) |
| FFC: | NCS54_01171500 NCS54_01418400 |
| FKR: | NCS57_01162100 NCS57_01400300 |
| PCHM: | VFPPC_03863 VFPPC_14013 |
| VAL: | VDBG_01893 VDBG_07639 |
| VDA: | VDAG_01664 VDAG_09360 |
| CHIG: | CH63R_03890 CH63R_07103 |
| ANI: | ANIA_08249 ANIA_11065 |
| AFM: | AFUA_4G12040 AFUA_5G04080 |
| NFI: | NFIA_038030 NFIA_104210 |
| AOR: | AO090020000194 AO090102000611 AO090166000068 |
| ANG: | An09g01330 An09g06490 |
| AFV: | AFLA_010467 AFLA_011429 AFLA_012044 |
| ALUC: | AKAW2_40649S(ERG7_3) |
| APUU: | APUU_20800A(ERG7_1) APUU_31278A(ERG7_2) APUU_60585A(ERG7_3) |
| PCS: | N7525_004959 N7525_010232 |
| CIM: | CIMG_02792 CIMG_06646 |
| CPW: | CPC735_031030 CPC735_036410 |
| CCAC: | CcaHIS019_0100810(ERG7) |
| ABP: | AGABI1DRAFT55056(AGABI1DRAFT_55056) |
| ABV: | AGABI2DRAFT206259(AGABI2DRAFT_206259) |
| MPR: | MPER_02146 MPER_03149 |
| MORE: | E1B28_003115 E1B28_007407 |
| PTRC: | PtA15_14A170 PtA15_9A541 |
| PSTR: | Pst134EA_009496 Pst134EA_021210 |
| TCR: | 506825.170 508175.70 |
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| Reference |
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| Authors |
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ |
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| Title |
A soluble 2,3-oxidosqualene sterol cyclase. |
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| Journal |
J Biol Chem 242:3014-5 (1967) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.4.99.7 |
| ExPASy - ENZYME nomenclature database: | 5.4.99.7 |
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