KEGG ENZYME: 5.5.1.17

ENZYME: 5.5.1.17

Entry

EC 5.5.1.17                 Enzyme

Name

(S)-beta-macrocarpene synthase;
TPS6;
TPS11;
(S)-beta-macrocarpene lyase (decyclizing)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

(S)-beta-macrocarpene lyase (ring-opening)

Reaction(IUBMB)

(S)-beta-bisabolene = (S)-beta-macrocarpene [RN:R09625]

Reaction(KEGG)

R09625

Substrate

(S)-beta-bisabolene [CPD:C16775]

Product

(S)-beta-macrocarpene [CPD:C19752]

Comment

The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene (cf. EC 4.2.3.55, (S)-beta-bisabolene synthase). The second step is the isomerization to (S)-beta-macrocarpene.

History

EC 5.5.1.17 created 2011

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K15797

(S)-beta-macrocarpene synthase

Genes

BDI:

100841139

TDC:

119267057

TAES:

123056762 123064867 123067408

ZMA:	103641097 103641099 542688

SITA:

101778298

SVS:

117859543

PVIR:

120677227 120711515

PHAI:

112896878

Reference

1 [PMID:18524777]

Authors

Kollner TG, Schnee C, Li S, Svatos A, Schneider B, Gershenzon J, Degenhardt J

Title

Protonation of a neutral (S)-beta-bisabolene intermediate is involved in (S)-beta-macrocarpene formation by the maize sesquiterpene synthases TPS6 and TPS11.

Journal

J Biol Chem 283:20779-88 (2008)
DOI:10.1074/jbc.M802682200

Sequence

[zma:103641097 542688]

Other DBs

ExplorEnz - The Enzyme Database:

5.5.1.17

IUBMB Enzyme Nomenclature:

5.5.1.17

ExPASy - ENZYME nomenclature database:

5.5.1.17

BRENDA, the Enzyme Database:

5.5.1.17

DBGET integrated database retrieval system