KEGG ENZYME: 5.5.1.20

ENZYME: 5.5.1.20

Entry

EC 5.5.1.20                 Enzyme

Name

prosolanapyrone-III cycloisomerase;
Sol5 (ambiguous);
SPS (ambiguous);
solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

prosolanapyrone-III:(-)-solanapyrone A isomerase

Reaction(IUBMB)

prosolanapyrone III = (-)-solanapyrone A [RN:R09918]

Reaction(KEGG)

R09918

Substrate

prosolanapyrone III [CPD:C19934]

Product

(-)-solanapyrone A [CPD:C20201]

Comment

The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 1.1.3.42, prosolanapyrone II oxidase).

History

EC 5.5.1.20 created 2011

Orthology

K20550

prosolanapyrone-II oxidase / prosolanapyrone-III cycloisomerase

Genes

ARAB:

EKO05_0006132

Reference

1 [PMID:20486243]

Authors

Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I

Title

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani.

Journal

Chembiochem 11:1245-52 (2010)
DOI:10.1002/cbic.201000173

Sequence

[ag:BAJ09785]

Reference

2 [PMID:9659400]

Authors

Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A

Title

Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction.

Journal

Biochim Biophys Acta 1384:387-95 (1998)
DOI:10.1016/S0167-4838(98)00040-5