KEGG ENZYME: 6.2.1.37

ENZYME: 6.2.1.37

Entry

EC 6.2.1.37                 Enzyme

Name

3-hydroxybenzoate---CoA ligase;
3-hydroxybenzoyl-CoA synthetase;
3-hydroxybenzoate---coenzyme A ligase (AMP-forming);
3-hydroxybenzoyl coenzyme A synthetase;
3-hydroxybenzoyl-CoA ligase

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

3-hydroxybenzoate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + 3-hydroxybenzoate + CoA = AMP + diphosphate + 3-hydroxybenzoyl-CoA [RN:R09589]

Reaction(KEGG)

R09589

Substrate

ATP [CPD:C00002];
3-hydroxybenzoate [CPD:C00587];
CoA [CPD:C00010]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
3-hydroxybenzoyl-CoA [CPD:C05195]

Comment

The enzyme works equally well with 4-hydroxybenzoate but shows low activity towards benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate. There is no activity with 3,4-dihydroxybenzoate, 2,3-dihydroxybenzoate, and 2-hydroxybenzoate as substrates.

History

EC 6.2.1.37 created 2011

Orthology

K20458

3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase

Genes

EBA:	ebA727(hbcL)

ABRE:

pbN1_30670(hbcL)

APET:

ToN1_26910(hbcL)

AZI:	AzCIB_4612

AZD:	CDA09_22605

TCL:

Tchl_2972

TAK:	Tharo_1872

DDZ:	DSYM_23670

RHZ:	RHPLAN_70010

MAGX:

XM1_3957(hcl)

MAGN:

WV31_08755

MAG:

amb1551

» show all

Reference

1 [PMID:11208796]

Authors

Laempe D, Jahn M, Breese K, Schagger H, Fuchs G

Title

Anaerobic metabolism of 3-hydroxybenzoate by the denitrifying bacterium Thauera aromatica.

Journal

J Bacteriol 183:968-79 (2001)
DOI:10.1128/JB.183.3.968-979.2001

Sequence

[ag:CAC28158]

Other DBs

ExplorEnz - The Enzyme Database:

6.2.1.37

IUBMB Enzyme Nomenclature:

6.2.1.37

ExPASy - ENZYME nomenclature database:

6.2.1.37

BRENDA, the Enzyme Database:

6.2.1.37

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (13)   
   KEGG MGENES (17)   
Protein sequence (10)   
   UniProt (9)   
   SWISS-PROT (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (5)   
   InterPro (5)   
All databases (59)   

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