KEGG   ENZYME: 6.2.1.9
Entry
EC 6.2.1.9                  Enzyme                                 
Name
malate---CoA ligase;
malyl-CoA synthetase;
malyl coenzyme A synthetase;
malate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
malate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + malate + CoA = ADP + phosphate + malyl-CoA [RN:R01256]
Reaction(KEGG)
R01256
Substrate
ATP [CPD:C00002];
malate [CPD:C00149];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
malyl-CoA [CPD:C04348]
History
EC 6.2.1.9 created 1972
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08692  malate-CoA ligase subunit alpha
K14067  malate-CoA ligase subunit beta
Genes
MCA: MCA1740(sucC-2) MCA1741(sucD-2)
METU: GNH96_10425(sucC)
MMEO: OOT43_04280(sucC) OOT43_04285(sucD)
MMT: Metme_2693 Metme_2694
MDN: JT25_000145 JT25_000150(sucC)
MDH: AYM39_08395(sucC) AYM39_08400
MKO: MKLM6_1753 MKLM6_1754
METL: U737_10265 U737_10270(sucD)
MPAD: KEF85_03355 KEF85_03360(sucD)
MELL: IVG45_03095 IVG45_03100(sucD)
MRP: NM686_005360 NM686_005365(sucD)
MMOT: QZJ86_13260(sucD) QZJ86_13265
MAH: MEALZ_3215(mtkB) MEALZ_3216(mtkA)
MBUR: EQU24_04635 EQU24_04640(sucD)
MPSY: CEK71_18040 CEK71_18045
MMAI: sS8_2224
MSZE: MSZNOR_4942(sucD) MSZNOR_4943(sucC)
MMOB: F6R98_20175(sucC)
MEIN: methR_P0950 methR_P0951
MOZ: MoryE10_14050(sucC) MoryE10_14060(sucD)
MISZ: MishRS11D_11810(sucD_2) MishRS11D_11820(sucC_2)
MESL: KKZ03_00250(sucD) KKZ03_00255
MEIY: MIN45_P1850 MIN45_P1851
MCAU: MIT9_P1451 MIT9_P1452
TSN: W908_06420 W908_06425(sucC)
BPH: Bphy_5926 Bphy_5927
BCAI: K788_0001576 K788_0001577
PHS: C2L64_21715 C2L64_21720
PTER: C2L65_26275 C2L65_26280
PSAA: QEN71_33985(sucD) QEN71_33990
PPAI: E1956_20555 E1956_20560(sucD)
MPT: Mpe_A3256 Mpe_A3257
METP: C1M51_05905 C1M51_05910
NEU: NE1810 NE1811
NET: Neut_0605 Neut_0606
NIT: NAL212_0421 NAL212_0422
NII: Nit79A3_0104 Nit79A3_0105
NCO: AAW31_08290(sucC) AAW31_08295
NUR: ATY38_03745 ATY38_03750(sucC)
NST: Nstercoris_01829 Nstercoris_01830
NMU: Nmul_A1079 Nmul_A1080
NLC: EBAPG3_012570 EBAPG3_012575
NIZ: NNRS527_01105 NNRS527_01106
METR: BSY238_255(sucD) BSY238_256(sucC)
NIM: W01_13790(sucC_1)
NARC: NTG6680_0559(mtkB) NTG6680_0560(mtkA)
FMY: HO273_03885 HO273_03890(sucD)
MLO: mlr1324 mlr1326
MLN: A9174_19855 A9174_19860
MOP: Mesop_3791 Mesop_3792
MAM: Mesau_03582 Mesau_03583
MAMO: A6B35_22115(sucC) A6B35_22120
MESP: C1M53_18675 C1M53_18680
MHUA: MCHK_2943 MCHK_2944(sucD)
MJR: EB229_19615(sucD) EB229_19620
MERD: EB233_16960(sucD) EB233_16965
AAK: AA2016_5787 AA2016_5788
AMIH: CO731_05426(sucC_2) CO731_05427(sucD_2)
AMIS: Amn_pa02880 Amn_pa02890
ANJ: AMD1_PA0301 AMD1_PA0302
PHT: BLM14_27155 BLM14_27160
RHI: NGR_c26240 NGR_c26250
SFH: SFHH103_02475(succ1) SFHH103_02476(sucd1)
SFD: USDA257_c22010(mtkB) USDA257_c22020(mtkA)
SAME: SAMCFNEI73_pC0657(mtkA) SAMCFNEI73_pC0658(mtkB)
SINO: SS05631_b61270 SS05631_b61280
ESJ: SJ05684_b48790 SJ05684_b48800
EAK: EKH55_4316 EKH55_4317
ENU: PYH37_000577 PYH37_000578(sucD)
EGI: PZN02_002070 PZN02_002071(sucD)
STEG: QA637_13115(sucD) QA637_13120
LNE: FZC33_08685(sucD) FZC33_08690
MEA: Mex_1p1730(mtkA) Mex_1p1731(mtkB)
MDI: METDI2482(mtkA) METDI2483(mtkB)
MEX: Mext_1799 Mext_1800
MCH: Mchl_2135 Mchl_2136
MPO: Mpop_1751 Mpop_1752
MZA: B2G69_16655 B2G69_16660
MRD: Mrad2831_3665 Mrad2831_3666
MET: M446_6556 M446_6557
MNO: Mnod_7116 Mnod_7117
MOR: MOC_4188 MOC_4189
META: Y590_08600(sucC) Y590_08605
MAQU: Maq22A_c19260(mtkB) Maq22A_c19265(mtkA)
MPHY: MCBMB27_03147 MCBMB27_03148
MEE: DA075_26540 DA075_26545
METD: C0214_10365 C0214_10370
METX: A3862_13155 A3862_13160
METS: DK389_15345 DK389_15350
METI: DK427_15540 DK427_15545
MMES: MMSR116_21300
MTEA: DK419_14275 DK419_14280
MIND: mvi_28880 mvi_28890(sucC_2)
MOG: MMB17_01135 MMB17_01140(sucD)
MTAD: M6G65_20430(sucD) M6G65_20435
MSL: Msil_1716 Msil_1717
MTUN: MTUNDRAET4_3404 MTUNDRAET4_3406(mtkA)
MLG: CWB41_04705 CWB41_04710
MEDK: QEV83_04550(sucD) QEV83_04555
BBAR: RHAL1_03823(sucC_2) RHAL1_03824(sucD_2)
HDN: Hden_3151 Hden_3152
HDT: HYPDE_38933 HYPDE_38938
HMC: HYPMC_4393(mtkB) HYPMC_4394(mtkA)
HNI: W911_15810(sucC) W911_15815
FIL: BN1229_v1_1241(sucC) BN1229_v1_1242(sucD) BN1229_v1_2531(mtkA)
FIY: BN1229_v1_1239(sucC) BN1229_v1_1240(sucD) BN1229_v1_3385(mtkA)
MCG: GL4_3373 GL4_3374
METG: HT051_02830 HT051_02835(sucD)
MSC: BN69_1173 BN69_1174(sucC1)
MBRY: B1812_17525 B1812_17530
MROS: EHO51_12195(sucD) EHO51_12200
MHEY: H2LOC_011815(sucD) H2LOC_011820
MPAR: F7D14_09160 F7D14_09165(sucD)
MIWA: SS37A_07160(sucC_1) SS37A_07170
MTW: CQW49_12220 CQW49_12225
MECQ: MSC49_04630 MSC49_04640(sucC_1)
CMET: K6K41_15070(sucD)
PLEO: OHA_1_00679(sucD_1) OHA_1_00680(sucC_1)
HDI: HDIA_2218(sucC_1) HDIA_2219(sucD_2)
NOH: G5V57_12990(sucD) G5V57_12995
SIL: SPO1568 SPO1569
RUA: D1823_20505 D1823_20510
RUT: FIU92_19880(sucD2) FIU92_19885(sucC2)
RCON: K3740_20015 K3740_20020(sucD)
RDE: RD1_1162(mtkA) RD1_1163(mtkB) RD1_4246(mtkB)
RLI: RLO149_c036810(mtkB) RLO149_c036820(mtkA)
DSH: Dshi_2491(sucC2) Dshi_2492(sucD2)
LMD: METH_18370 METH_18375(sucC)
LEJ: ETW24_17890(sucD) ETW24_17895
LAQU: R2C4_19805 R2C4_19810(sucD)
LEV: ETW23_00265 ETW23_00270(sucD)
LCAE: K3721_16165(sucD) K3721_16170
RED: roselon_02261 roselon_02262
CID: P73_3959 P73_3960
RMM: ROSMUCSMR3_01020(sucC) ROSMUCSMR3_03453(sucD) ROSMUCSMR3_03454(sucC)
ROK: RAK1035_2338 RAK1035_2339 RAK1035_3888
RID: RIdsm_02780(sucC_1) RIdsm_02781(sucD_1)
ROM: EI983_08260(sucD) EI983_08265
ROH: FIU89_03745(sucC1) FIU89_11590(sucC3) FIU89_11595(sucD3)
RPEL: N7U68_03485 N7U68_03490(sucD)
SAGU: CDO87_15510 CDO87_15515
RMH: LVO79_00250 LVO79_00255(sucD)
MALU: KU6B_14470(sucC_1) KU6B_14480 KU6B_40000 KU6B_40010(sucC_2)
PALX: GQA70_23235 GQA70_23240(sucD)
RMAI: MACH21_17100(sucC_2) MACH21_17110
PAMI: JCM7686_2766 JCM7686_2767
PZH: CX676_04825 CX676_04830
PAMN: pAMV1p0131(mtkA) pAMV1p0132(mtkB)
PSAP: JHX88_17875(sucD) JHX88_17880 JHX88_20295(sucD) JHX88_20300
PALP: JHW40_18545 JHW40_18550(sucD)
RBG: BG454_05620 BG454_05625
GEH: HYN69_16135 HYN69_16140
GFU: KM031_08945(sucD) KM031_08950
TAW: EI545_00085 EI545_00090(sucD)
PAED: G5B38_01655(sucD) G5B38_01660
NSM: JO391_00305(sucD) JO391_00310
AMYL: QBD29_08395(sucD) QBD29_08400
AMAQ: GO499_03740 GO499_03745(sucD)
GBE: GbCGDNIH1_0052 GbCGDNIH1_0053
GBH: GbCGDNIH2_0052 GbCGDNIH2_0053
GBC: GbCGDNIH3_0052 GbCGDNIH3_0053
GBS: GbCGDNIH4_0052 GbCGDNIH4_0053
 » show all
Reference
1  [PMID:14244056]
  Authors
MUE S, TUBOI S, KIKUCHI G.
  Title
ON MALYL-COENZYME A SYNTHETASE.
  Journal
J Biochem 56:545-51 (1964)
DOI:10.1093/oxfordjournals.jbchem.a128032
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.9
IUBMB Enzyme Nomenclature: 6.2.1.9
ExPASy - ENZYME nomenclature database: 6.2.1.9
BRENDA, the Enzyme Database: 6.2.1.9
CAS: 37318-58-4

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Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (16777)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (328)   
   KEGG MGENES (13458)   
   RefGene (2989)   
Protein sequence (23)   
   UniProt (14)   
   SWISS-PROT (3)   
   RefSeq(pep) (6)   
DNA sequence (129)   
   RefSeq(nuc) (11)   
   GenBank (60)   
   EMBL (58)   
Protein domain (13)   
   InterPro (12)   
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All databases (16960)   

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