KEGG   DRUG: Ficerafusp alfa
Entry
D12768                      Drug                                   
Name
Ficerafusp alfa (USAN)
Formula
C7848H12104N2108O2492S70
Exact mass
177990.5664
Mol weight
178101.2578
Sequence
(Heavy chain)
QVQLKQSGPG LVQPSQSLSI TCTVSGFSLT NYGVHWVRQS PGKGLEWLGV IWSGGNTDYN
TPFTSRLSIN KDNSKSQVFF KMNSLQSNDT AIYYCARALT YYDYEFAYWG QGTLVTVSAA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPG
(Light chain)
DILLTQSPVI LSVSPGERVS FSCRASQSIG TNIHWYQQRT NGSPRLLIKY ASESISGIPS
RFSGSGSGTD FTLSINSVES EDIADYYCQQ NNNWPTTFGA GTKLELKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGECGGGGSG GGGSGGGGST IPPHVQKSVN
NDMIVTDNNG AVKFPQLCKF CDVRFSTCDN QKSCMSNCSI TSICEKPQEV CVAVWRKNDE
NITLETVCHD PKLPYHDFIL EDAASPKCIM KEKKKPGETF FMCSCSSDEC NDNIIFSEEY
NTSNPD
(Disulfide bridge: H22-H95, H146-H202, H222-L214, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'95, H'146-H'202, H'222-L'214, H'263-H'323, H'369-H'427, L23-L88, L134-L194, L258-L261, L268-L274, L278-L284, L291-L308, L328-L343, L345-L350, L'23-L'88, L'134-L'194, L'258-L'261, L'268-L'274, L'278-L'284, L'291-L'308 L'328-L'343, L'345-L'350)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Bifunctional fusion protein
Target
EGFR [HSA:1956] [KO:K04361]
TGFBR2 [HSA:7048] [KO:K04388]
  Pathway
hsa04010  MAPK signaling pathway
hsa04068  FoxO signaling pathway
hsa04144  Endocytosis
hsa04520  Adherens junction
hsa04926  Relaxin signaling pathway
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor serine/threonine kinases (RSTK)
   TGFBR2 family
    TGFBR2
     D12768  Ficerafusp alfa (USAN)
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR
     D12768  Ficerafusp alfa (USAN)
Other DBs
CAS: 2764727-44-6

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