KEGG   DRUG: Zigakibart
Entry
D12800                      Drug                                   
Name
Zigakibart (USAN/INN)
Formula
C6434H9912N1696O2026S50
Exact mass
144951.0758
Mol weight
145040.9427
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYVMHWVRQA PGQGLEWMGY INPYNDAPKY
NEKFKGKATM TSDTSASTAY MELSSLRSDD TAVYYCARGL GYALYYAMDY WGQGTTVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE SKYGPPCPPC PAPEFLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY TLPPSQEEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSR LTVDKSRWQE
GNVFSCSVMH EALHNHYTQK SLSLSLGK
(Light chain)
DIVMTQSPST LSASVGDRVT ITCKASQNVG NNVAWYQQKP GKAPKLLISS ASNRDSGVPS
RFSGSGSGTE FTLTISSLQP DDFATYFCQQ YNIYPFTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H135-L214, H148-H204, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'135-L'214, H'148-H'204, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-'88, L'134-L'194)
  Type
Peptide
Efficacy
Anti-inflammatory
  Type
Monoclonal antibody
Comment
Treatment of IgA nephropathy in adults
Target
TNFSF13 (APRIL, CD256) [HSA:8741] [KO:K05475]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF13 (APRIL, CD256)
     D12800  Zigakibart (USAN/INN)
Other DBs
CAS: 2642175-46-8

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