KEGG   Homo sapiens (human): 1024
Entry
1024              CDS       T01001                                 
Symbol
CDK8, IDDHBA, K35
Name
(RefSeq) cyclin dependent kinase 8
  KO
K02208  cyclin-dependent kinase 8/11 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Disease
H02463  Syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1024 (CDK8)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    1024 (CDK8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1024 (CDK8)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     1024 (CDK8)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1024 (CDK8)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Mediator complex
    CDK-module
     1024 (CDK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo
Other DBs
NCBI-GeneID: 1024
NCBI-ProteinID: NP_001251
OMIM: 603184
HGNC: 1779
Ensembl: ENSG00000132964
UniProt: P49336
Structure
Position
13:26254129..26405238
AA seq 464 aa
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
NT seq 1395 nt   +upstreamnt  +downstreamnt
atggactatgactttaaagtgaagctgagcagcgagcgggagcgggtcgaggacctgttt
gaatacgagggctgcaaagttggccgaggcacttatggtcacgtctacaaagccaagagg
aaagatgggaaggatgataaagactatgctttaaaacaaatagaaggaactgggatctct
atgtcggcatgtagagaaatagcattacttcgagagcttaagcatccaaacgtcatttct
cttcaaaaggtgtttctgtctcatgctgataggaaggtgtggcttctgtttgactatgct
gaacatgacctctggcatataatcaagtttcacagagcttctaaagcaaacaagaagcca
gttcagttacctcggggaatggtgaagtcactattatatcagatcctagatggtattcac
tacctgcatgctaactgggtgttgcacagagatttgaaacctgctaatattttagttatg
ggtgaaggtcctgagcgaggaagagtaaaaattgctgacatgggctttgcccgattattt
aattcacctttgaagcctttagcagatttggatccagtggttgttacattctggtaccga
gcccctgaactacttcttggagcaaggcattataccaaagctattgatatttgggctata
gggtgtatatttgcagaactactaacgtcagaaccaatatttcactgtcgacaagaggac
atcaaaactagtaatccttatcaccatgaccagctggacagaatattcaatgtaatggga
tttcctgcagataaagattgggaagatataaaaaagatgcctgaacattcaacattaatg
aaagatttcagaagaaatacgtataccaactgcagccttatcaagtatatggaaaaacat
aaagttaaaccagatagtaaagcattccacttgcttcagaagctgcttaccatggaccca
ataaagcgaattacctcagaacaggctatgcaggacccctatttcttagaagacccactt
cctacatcagacgtttttgccggttgtcaaatcccttacccaaaacgagaatttttaacg
gaagaagaacctgatgacaaaggagacaaaaagaaccagcagcagcagcagggcaataac
cacactaatggaactggccacccagggaatcaagacagcagtcacacacagggacccccg
ttgaagaaagtgagagttgttcctcctaccactacctcaggtggacttatcatgacctca
gactatcagcgttccaatccacatgctgcctatcccaaccctggaccaagcacatcacag
ccgcagagcagcatgggatactcagctacctcccagcagcctccacagtactcacatcag
acacatcggtactga

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Ontology (4)   
   KEGG BRITE (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (35)   
   RefSeq(nuc) (7)   
   GenBank (14)   
   EMBL (14)   
3D Structure (31)   
   PDB (31)   
Protein domain (3)   
   Pfam (3)   
All databases (120)   

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