KEGG   Homo sapiens (human): 1029
Entry
1029              CDS       T01001                                 
Symbol
CDKN2A, ARF, CAI2, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
Name
(RefSeq) cyclin dependent kinase inhibitor 2A
  KO
K06621  cyclin-dependent kinase inhibitor 2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04934  Cushing syndrome
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05206  MicroRNAs in cancer
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05225  Hepatocellular carcinoma
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle (cancer)
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00494  HTLV-1 Tax to p16-cell cycle G1/S
N00536  MDM2-p21-Cell cycle G1/S
Disease
H00004  Chronic myeloid leukemia
H00008  Burkitt lymphoma
H00009  Adult T-cell leukemia
H00014  Non-small cell lung cancer
H00015  Malignant pleural mesothelioma
H00016  Oral cancer
H00017  Esophageal cancer
H00019  Pancreatic cancer
H00022  Bladder cancer
H00025  Penile cancer
H00036  Osteosarcoma
H00038  Melanoma
H00040  Squamous cell carcinoma
H00042  Glioma
H00046  Cholangiocarcinoma
H00047  Gallbladder cancer
H00048  Hepatocellular carcinoma
H00054  Nasopharyngeal cancer
H00055  Laryngeal cancer
H01463  Mycosis fungoides
H01464  Mantle cell lymphoma
H01508  Salivary gland cancer
H01509  Tonsillar cancer
H01513  Retinoblastoma
H01556  Meningioma
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1029 (CDKN2A)
   04115 p53 signaling pathway
    1029 (CDKN2A)
   04218 Cellular senescence
    1029 (CDKN2A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1029 (CDKN2A)
   05206 MicroRNAs in cancer
    1029 (CDKN2A)
   05203 Viral carcinogenesis
    1029 (CDKN2A)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1029 (CDKN2A)
   05225 Hepatocellular carcinoma
    1029 (CDKN2A)
   05214 Glioma
    1029 (CDKN2A)
   05220 Chronic myeloid leukemia
    1029 (CDKN2A)
   05218 Melanoma
    1029 (CDKN2A)
   05219 Bladder cancer
    1029 (CDKN2A)
   05223 Non-small cell lung cancer
    1029 (CDKN2A)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1029 (CDKN2A)
   05163 Human cytomegalovirus infection
    1029 (CDKN2A)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1029 (CDKN2A)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    1029 (CDKN2A)
   01522 Endocrine resistance
    1029 (CDKN2A)
SSDB
Motif
Pfam: Ank Ank_4 Ank_2 Ank_5
Other DBs
NCBI-GeneID: 1029
NCBI-ProteinID: NP_000068
OMIM: 600160
HGNC: 1787
Ensembl: ENSG00000147889
UniProt: P42771 K7PML8
Structure
Position
9:complement(21967752..21995324)
AA seq 156 aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD
NT seq 471 nt   +upstreamnt  +downstreamnt
atggagccggcggcggggagcagcatggagccttcggctgactggctggccacggccgcg
gcccggggtcgggtagaggaggtgcgggcgctgctggaggcgggggcgctgcccaacgca
ccgaatagttacggtcggaggccgatccaggtcatgatgatgggcagcgcccgagtggcg
gagctgctgctgctccacggcgcggagcccaactgcgccgaccccgccactctcacccga
cccgtgcacgacgctgcccgggagggcttcctggacacgctggtggtgctgcaccgggcc
ggggcgcggctggacgtgcgcgatgcctggggccgtctgcccgtggacctggctgaggag
ctgggccatcgcgatgtcgcacggtacctgcgcgcggctgcggggggcaccagaggcagt
aaccatgcccgcatagatgccgcggaaggtccctcagacatccccgattga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (18)   
   KEGG PATHWAY (18)   
Network (24)   
   KEGG NETWORK (24)   
Disease (31)   
   KEGG DISEASE (27)   
   OMIM (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (53)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
   PROTHERM (31)   
Protein sequence (18)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (54)   
   RefSeq(nuc) (16)   
   GenBank (19)   
   EMBL (19)   
3D Structure (5)   
   PDB (5)   
Protein domain (4)   
   Pfam (4)   
All databases (209)   

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KEGG   Homo sapiens (human): 1030
Entry
1030              CDS       T01001                                 
Symbol
CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Name
(RefSeq) cyclin dependent kinase inhibitor 2B
  KO
K04685  cyclin-dependent kinase inhibitor 2B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04350  TGF-beta signaling pathway
hsa04934  Cushing syndrome
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05222  Small cell lung cancer
hsa05226  Gastric cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06267  Small cell lung cancer
  Element
N00088  Amplified MYC to p15-cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00495  HTLV-1 Tax to p15-cell cycle G1/S
Disease
H00015  Malignant pleural mesothelioma
H00036  Osteosarcoma
H01463  Mycosis fungoides
H01556  Meningioma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    1030 (CDKN2B)
   04068 FoxO signaling pathway
    1030 (CDKN2B)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1030 (CDKN2B)
   04218 Cellular senescence
    1030 (CDKN2B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1030 (CDKN2B)
   05203 Viral carcinogenesis
    1030 (CDKN2B)
  09162 Cancer: specific types
   05226 Gastric cancer
    1030 (CDKN2B)
   05222 Small cell lung cancer
    1030 (CDKN2B)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1030 (CDKN2B)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1030 (CDKN2B)
SSDB
Motif
Pfam: Ank_2 Ank Ank_4 Ank_5
Other DBs
NCBI-GeneID: 1030
NCBI-ProteinID: NP_004927
OMIM: 600431
HGNC: 1788
Ensembl: ENSG00000147883
UniProt: P42772 K7PPU3
Position
9:complement(22002903..22009313)
AA seq 138 aa
MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR
VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
EERGHRDVAGYLRTATGD
NT seq 417 nt   +upstreamnt  +downstreamnt
atgcgcgaggagaacaagggcatgcccagtgggggcggcagcgatgagggtctggccagc
gccgcggcgcggggactagtggagaaggtgcgacagctcctggaagccggcgcggatccc
aacggagtcaaccgtttcgggaggcgcgcgatccaggtcatgatgatgggcagcgcccgc
gtggcggagctgctgctgctccacggcgcggagcccaactgcgcagaccctgccactctc
acccgaccggtgcatgatgctgcccgggagggcttcctggacacgctggtggtgctgcac
cgggccggggcgcggctggacgtgcgcgatgcctggggtcgtctgcccgtggacttggcc
gaggagcggggccaccgcgacgttgcagggtacctgcgcacagccacgggggactga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (6)   
   KEGG NETWORK (6)   
Disease (6)   
   KEGG DISEASE (5)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
Protein domain (4)   
   Pfam (4)   
All databases (79)   

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KEGG   Homo sapiens (human): 1031
Entry
1031              CDS       T01001                                 
Symbol
CDKN2C, INK4C, p18, p18-INK4C
Name
(RefSeq) cyclin dependent kinase inhibitor 2C
  KO
K06622  cyclin-dependent kinase inhibitor 2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04110  Cell cycle
hsa04934  Cushing syndrome
hsa05166  Human T-cell leukemia virus 1 infection
hsa05202  Transcriptional misregulation in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06240  Transcription (cancer)
nt06360  Cushing syndrome
  Element
N00120  MLL-ENL fusion to transcriptional activation
N00290  Mutation-inactivated MEN1 to transcription
N00511  HTLV-1 Tax to E47-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1031 (CDKN2C)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    1031 (CDKN2C)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1031 (CDKN2C)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1031 (CDKN2C)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1031 (CDKN2C)
SSDB
Motif
Pfam: Ank_4 Ank_2 Ank Ank_5 Ank_3 DUF1843
Other DBs
NCBI-GeneID: 1031
NCBI-ProteinID: NP_001253
OMIM: 603369
HGNC: 1789
Ensembl: ENSG00000123080
UniProt: P42773 Q6ICV4
Structure
Position
1:50968706..50974634
AA seq 168 aa
MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
NT seq 507 nt   +upstreamnt  +downstreamnt
atggccgagccttgggggaacgagttggcgtccgcagctgccaggggggacctagagcaa
cttactagtttgttgcaaaataatgtaaacgtcaatgcacaaaatggatttggaaggact
gcgctgcaggttatgaaacttggaaatcccgagattgccaggagactgctacttagaggt
gctaatcccgatttgaaagaccgaactggtttcgctgtcattcatgatgcggccagagca
ggtttcctggacactttacagactttgctggagtttcaagctgatgttaacatcgaggat
aatgaagggaacctgcccttgcacttggctgccaaagaaggccacctccgggtggtggag
ttcctggtgaagcacacggccagcaatgtggggcatcggaaccataagggggacaccgcc
tgtgatttggccaggctctatgggaggaatgaggttgttagcctgatgcaggcaaacggg
gctgggggagccacaaatcttcaataa

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (6)   
   KEGG NETWORK (6)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (24)   
   RefSeq(nuc) (2)   
   GenBank (11)   
   EMBL (11)   
3D Structure (6)   
   PDB (6)   
Protein domain (6)   
   Pfam (6)   
All databases (75)   

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KEGG   Homo sapiens (human): 1032
Entry
1032              CDS       T01001                                 
Symbol
CDKN2D, INK4D, p19, p19-INK4D
Name
(RefSeq) cyclin dependent kinase inhibitor 2D
  KO
K06623  cyclin-dependent kinase inhibitor 2D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    1032 (CDKN2D)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1032 (CDKN2D)
SSDB
Motif
Pfam: Ank_2 Ank Ank_5 Ank_4 Ank_3
Other DBs
NCBI-GeneID: 1032
NCBI-ProteinID: NP_001791
OMIM: 600927
HGNC: 1790
Ensembl: ENSG00000129355
UniProt: P55273
Structure
Position
19:complement(10566460..10568979)
AA seq 166 aa
MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
NT seq 501 nt   +upstreamnt  +downstreamnt
atgctgctggaggaggttcgcgccggcgaccggctgagtggggcggcggcccggggcgac
gtgcaggaggtgcgccgccttctgcaccgggagctggtgcatcccgacgccctcaaccgc
ttcggcaagacggcgctgcaggtcatgatgtttggcagcaccgccatcgccctggagctg
ctgaagcaaggtgccagccccaatgtccaggacacctccggtaccagtccagtccatgac
gcagcccgcactggattcctggacaccctgaaggtcctagtggagcacggggctgatgtc
aacgtgcctgatggcaccggggcacttccaatccatctggcagttcaagagggtcacact
gctgtggtcagctttctggcagctgaatctgatctccatcgcagggacgccaggggtctc
acacccttggagctggcactgcagagaggggctcaggacctcgtggacatcctgcagggc
cacatggtggccccgctgtga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
   PROTHERM (2)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (51)   

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