KEGG   Homo sapiens (human): 103
Entry
103               CDS       T01001                                 
Symbol
ADAR, ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136
Name
(RefSeq) adenosine deaminase RNA specific
  KO
K12968  double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05162  Measles
hsa05164  Influenza A
hsa05171  Coronavirus disease - COVID-19
Network
nt06519  RLR signaling
  Element
N01565  Adenosine-to-inosine RNA editing by ADAR
Disease
H00290  Aicardi-Goutieres syndrome
H00880  Dyschromatosis symmetrica hereditaria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    103 (ADAR)
   04623 Cytosolic DNA-sensing pathway
    103 (ADAR)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    103 (ADAR)
   05164 Influenza A
    103 (ADAR)
   05162 Measles
    103 (ADAR)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    103 (ADAR)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.37  double-stranded RNA adenine deaminase
     103 (ADAR)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   RNA binding proteins (RBPs)
    103 (ADAR)
SSDB
Motif
Pfam: A_deamin z-alpha dsrm DND1_DSRM TrmB
Other DBs
NCBI-GeneID: 103
NCBI-ProteinID: NP_001102
OMIM: 146920
HGNC: 225
Ensembl: ENSG00000160710
UniProt: P55265
Structure
Position
1:complement(154582057..154627997)
AA seq 1226 aa
MNPRQGYSLSGYYTHPFQGYEHRQLRYQQPGPGSSPSSFLLKQIEFLKGQLPEAPVIGKQ
TPSLPPSLPGLRPRFPVLLASSTRGRQVDIRGVPRGVHLRSQGLQRGFQHPSPRGRSLPQ
RGVDCLSSHFQELSIYQDQEQRILKFLEELGEGKATTAHDLSGKLGTPKKEINRVLYSLA
KKGKLQKEAGTPPLWKIAVSTQAWNQHSGVVRPDGHSQGAPNSDPSLEPEDRNSTSVSED
LLEPFIAVSAQAWNQHSGVVRPDSHSQGSPNSDPGLEPEDSNSTSALEDPLEFLDMAEIK
EKICDYLFNVSDSSALNLAKNIGLTKARDINAVLIDMERQGDVYRQGTTPPIWHLTDKKR
ERMQIKRNTNSVPETAPAAIPETKRNAEFLTCNIPTSNASNNMVTTEKVENGQEPVIKLE
NRQEARPEPARLKPPVHYNGPSKAGYVDFENGQWATDDIPDDLNSIRAAPGEFRAIMEMP
SFYSHGLPRCSPYKKLTECQLKNPISGLLEYAQFASQTCEFNMIEQSGPPHEPRFKFQVV
INGREFPPAEAGSKKVAKQDAAMKAMTILLEEAKAKDSGKSEESSHYSTEKESEKTAESQ
TPTPSATSFFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSV
SAPSKKVAKQMAAEEAMKALHGEATNSMASDNQPEGMISESLDNLESMMPNKVRKIGELV
RYLNTNPVGGLLEYARSHGFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQG
KQEAADAALRVLIGENEKAERMGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTF
HDQIAMLSHRCFNTLTNSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLS
LKGETVNDCHAEIISRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLY
ISTAPCGDGALFDKSCSDRAMESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVP
TWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAI
CCRVTRDGSAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLADGYDLEILD
GTRGTVDGPRNELSRVSKKNIFLLFKKLCSFRYRRDLLRLSYGEAKKAARDYETAKNYFK
KGLKDMGYGNWISKPQEEKNFYLCPV
NT seq 3681 nt   +upstreamnt  +downstreamnt
atgaatccgcggcaggggtattccctcagcggatactacacccatccatttcaaggctat
gagcacagacagctcaggtaccagcagcctgggccaggatcttcccccagtagtttcctg
cttaagcaaatagaatttctcaaggggcagctcccagaagcaccggtgattggaaagcag
acaccgtcactgccaccttccctcccaggactccggccaaggtttccagtactacttgcc
tccagtaccagaggcaggcaagtggacatcaggggtgtccccaggggcgtgcatctcaga
agtcaggggctccagagagggttccagcatccttcaccacgtggcaggagtctgccacag
agaggtgttgattgcctttcctcacatttccaggaactgagtatctaccaagatcaggaa
caaaggatcttaaagttcctggaagagcttggggaagggaaggccaccacagcacatgat
ctgtctgggaaacttgggactccgaagaaagaaatcaatcgagttttatactccctggca
aagaagggcaagctacagaaagaggcaggaacaccccctttgtggaaaatcgcggtctcc
actcaggcttggaaccagcacagcggagtggtaagaccagacggtcatagccaaggagcc
ccaaactcagacccgagtttggaaccggaagacagaaactccacatctgtctcagaagat
cttcttgagccttttattgcagtctcagctcaggcttggaaccagcacagcggagtggta
agaccagacagtcatagccaaggatccccaaactcagacccaggtttggaacctgaagac
agcaactccacatctgccttggaagatcctcttgagtttttagacatggccgagatcaag
gagaaaatctgcgactatctcttcaatgtgtctgactcctctgccctgaatttggctaaa
aatattggccttaccaaggcccgagatataaatgctgtgctaattgacatggaaaggcag
ggggatgtctatagacaagggacaacccctcccatatggcatttgacagacaagaagcga
gagaggatgcaaatcaagagaaatacgaacagtgttcctgaaaccgctccagctgcaatc
cctgagaccaaaagaaacgcagagttcctcacctgtaatatacccacatcaaatgcctca
aataacatggtaaccacagaaaaagtggagaatgggcaggaacctgtcataaagttagaa
aacaggcaagaggccagaccagaaccagcaagactgaaaccacctgttcattacaatggc
ccctcaaaagcagggtatgttgactttgaaaatggccagtgggccacagatgacatccca
gatgacttgaatagtatccgcgcagcaccaggtgagtttcgagccatcatggagatgccc
tccttctacagtcatggcttgccacggtgttcaccctacaagaaactgacagagtgccag
ctgaagaaccccatcagcgggctgttagaatatgcccagttcgctagtcaaacctgtgag
ttcaacatgatagagcagagtggaccaccccatgaacctcgatttaaattccaggttgtc
atcaatggccgagagtttcccccagctgaagctggaagcaagaaagtggccaagcaggat
gcagctatgaaagccatgacaattctgctagaggaagccaaagccaaggacagtggaaaa
tcagaagaatcatcccactattccacagagaaagaatcagagaagactgcagagtcccag
acccccaccccttcagccacatccttcttttctgggaagagccccgtcaccacactgctt
gagtgtatgcacaaattggggaactcctgcgaattccgtctcctgtccaaagaaggccct
gcccatgaacccaagttccaatactgtgttgcagtgggagcccaaactttccccagtgtg
agtgctcccagcaagaaagtggcaaagcagatggccgcagaggaagccatgaaggccctg
catggggaggcgaccaactccatggcttctgataaccagcctgaaggtatgatctcagag
tcacttgataacttggaatccatgatgcccaacaaggtcaggaagattggcgagctcgtg
agatacctgaacaccaaccctgtgggtggccttttggagtacgcccgctcccatggcttt
gctgctgaattcaagttggtcgaccagtccggacctcctcacgagcccaagttcgtttac
caagcaaaagttgggggtcgctggttcccagccgtctgcgcacacagcaagaagcaaggc
aagcaggaagcagcagatgcggctctccgtgtcttgattggggagaacgagaaggcagaa
cgcatgggtttcacagaggtaaccccagtgacaggggccagtctcagaagaactatgctc
ctcctctcaaggtccccagaagcacagccaaagacactccctctcactggcagcaccttc
catgaccagatagccatgctgagccaccggtgcttcaacactctgactaacagcttccag
ccctccttgctcggccgcaagattctggccgccatcattatgaaaaaagactctgaggac
atgggtgtcgtcgtcagcttgggaacagggaatcgctgtgtgaaaggagattctctcagc
ctaaaaggagaaactgtcaatgactgccatgcagaaataatctcccggagaggcttcatc
aggtttctctacagtgagttaatgaaatacaactcccagactgcgaaggatagtatattt
gaacctgctaagggaggagaaaagctccaaataaaaaagactgtgtcattccatctgtat
atcagcactgctccgtgtggagatggcgccctctttgacaagtcctgcagcgaccgtgct
atggaaagcacagaatcccgccactaccctgtcttcgagaatcccaaacaaggaaagctc
cgcaccaaggtggagaacggagaaggcacaatccctgtggaatccagtgacattgtgcct
acgtgggatggcattcggctcggggagagactccgtaccatgtcctgtagtgacaaaatc
ctacgctggaacgtgctgggcctgcaaggggcactgttgacccacttcctgcagcccatt
tatctcaaatctgtcacattgggttaccttttcagccaagggcatctgacccgtgctatt
tgctgtcgtgtgacaagagatgggagtgcatttgaggatggactacgacatccctttatt
gtcaaccaccccaaggttggcagagtcagcatatatgattccaaaaggcaatccgggaag
actaaggagacaagcgtcaactggtgtctggctgatggctatgacctggagatcctggac
ggtaccagaggcactgtggatgggccacggaatgaattgtcccgggtctccaaaaagaac
atttttcttctatttaagaagctctgctccttccgttaccgcagggatctactgagactc
tcctatggtgaggccaagaaagctgcccgtgactacgagacggccaagaactacttcaaa
aaaggcctgaaggatatgggctatgggaactggattagcaaaccccaggaggaaaagaac
ttttatctctgcccagtatag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (24)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (22)   
DNA sequence (84)   
   RefSeq(nuc) (22)   
   GenBank (31)   
   EMBL (31)   
3D Structure (20)   
   PDB (20)   
Protein domain (5)   
   Pfam (5)   
All databases (178)   

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