KEGG   Homo sapiens (human): 10594
Entry
10594             CDS       T01001                                 
Symbol
PRPF8, HPRP8, PRP8, PRPC8, RP13, SNRNP220
Name
(RefSeq) pre-mRNA processing factor 8
  KO
K12856  pre-mRNA-processing factor 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03040  Spliceosome
Disease
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    10594 (PRPF8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    10594 (PRPF8)
Spliceosome [BR:hsa03041]
 Complex B
  U4/U6.U5 tri-snRNP components
   U5 snRNP specific factors
    10594 (PRPF8)
 Complex C
   U5 SnRNP specific factors
    10594 (PRPF8)
SSDB
Motif
Pfam: PROCN PRP8_domainIV U6-snRNA_bdg PRO8NT U5_2-snRNA_bdg PROCT RRM_4 JAB
Other DBs
NCBI-GeneID: 10594
NCBI-ProteinID: NP_006436
OMIM: 607300
HGNC: 17340
Ensembl: ENSG00000174231
UniProt: Q6P2Q9
Structure
Position
17:complement(1650629..1684867)
AA seq 2335 aa
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
NT seq 7008 nt   +upstreamnt  +downstreamnt
atggccggagtgtttccttatcgagggccgggtaacccggtgcctggccctctagccccg
ctaccggactacatgtcggaggagaagctgcaggagaaagctcgaaaatggcagcaattg
caggccaagcgctatgcagaaaagcggaagtttgggtttgtggatgcccagaaggaagac
atgcccccagaacatgtcaggaagatcattcgagaccatggagacatgaccaacaggaag
ttccgccatgacaaaagggtttacttgggtgccctaaagtacatgccccacgcagtcctc
aaactcctggagaacatgcctatgccttgggagcagattcgggatgtgcctgtgctgtac
cacatcactggagccatttccttcgtcaatgagattccctgggtcattgaacctgtctac
atctcccagtgggggtcaatgtggattatgatgcgccgagaaaaaagagataggaggcat
ttcaagaggatgcgttttcccccttttgatgatgaggagccgcccttggactatgctgac
aacatcctagatgttgagccactggaggccattcagctagagctggaccctgaggaggac
gcccctgtgttggactggttctatgaccaccagccgttgagggacagcaggaagtatgta
aatggctccacttaccagcgctggcagttcacactacctatgatgtcgactctctaccgc
ctggctaatcagctcctgacagacttggtggatgacaactacttctacctgtttgatttg
aaggccttctttacgtccaaggcactcaatatggccattcctggaggccccaaatttgaa
cctcttgttcgagacatcaacctacaggatgaagactggaatgaattcaatgatattaac
aagattatcatccggcagcctatccgcactgagtacaagattgcttttccttacttgtac
aacaatcttccacaccatgtccacctcacctggtaccatactcccaatgttgtattcatc
aaaactgaggatcctgacttgccagctttctactttgaccctttgatcaacccaatctcc
cataggcactcagtcaagagccaggaaccattgccggatgatgatgaggaatttgagctc
ccggagtttgtggagcccttcctgaaggacacacccctctatacagacaatacagccaat
ggcattgccctgctctgggccccgcggcccttcaacctacgctctggtcgcacccgtcgg
gccctggacataccccttgtcaagaactggtatcgggagcattgtcctgccgggcagcct
gtgaaagtgagggtctcctaccagaagctgcttaagtactatgtgctgaatgccctgaag
catcggccccctaaggctcaaaagaagaggtatttgttccgctccttcaaagccaccaaa
ttctttcagtccacaaagctggactgggtggaggttgggctccaggtttgccgccagggc
tacaacatgctcaaccttctcattcaccgcaaaaacctcaactacctgcacctggactac
aacttcaacctcaagcctgtgaaaacgctcaccaccaaggaaagaaagaaatctcgtttt
gggaatgctttccacctgtgtcgggaagttctgcgtttgactaagctggtggtggatagt
cacgtgcagtatcggctgggcaatgtggatgccttccagctggcagatggattgcagtat
atatttgcccatgttgggcagttgacgggcatgtatcgatacaaatacaagctgatgcga
cagattcgcatgtgcaaggacctgaagcatctcatctattatcgtttcaacacgggccct
gtagggaagggtcctggctgtggcttctgggctgccggttggcgagtctggctctttttc
atgcgtggcattacccctttattagagcgatggcttggcaacctcctggcccggcagttt
gaaggtcgacactcaaagggggtggcaaagacagtaacaaagcagcgagtggagtcacat
tttgaccttgagctgcgggcagctgtgatgcatgatattctggacatgatgcctgagggg
atcaagcagaacaaggcccggacaatcctgcagcacctcagtgaagcctggcgctgctgg
aaagccaacattccctggaaggtccctgggctgccgacgcccatagagaatatgatcctt
cgatacgtgaaggccaaggctgactggtggaccaacactgcccactacaaccgagaacgg
atccgccgaggggccactgtggacaagactgtttgtaaaaagaatctgggccgcctcacc
cggctctatctgaaggcagaacaggagcggcagcacaactacctgaaggacgggccttac
atcacagcggaggaagcagtggcagtatataccaccacagtgcattggttggaaagccgc
aggttttcacccatcccattccccccactctcctataagcatgacaccaagttgctcatc
ttggcattggagcggctcaaggaagcttatagtgtgaagtctcggttgaaccagtctcag
agggaggagctaggtctgatcgagcaggcctacgataacccccacgaggcgctgtcccgc
atcaagcgtcacctcctcacacagagagccttcaaagaggtgggcattgagttcatggat
ctgtatagccacctcgttccagtatatgatgttgagcccctggagaagataactgatgct
tacctggaccagtacctgtggtatgaagccgacaagcgccgcctgttcccaccctggatt
aagcctgcagacacagaaccacctccgctgcttgtttacaagtggtgtcaaggcatcaat
aacctgcaggacgtgtgggagacgagtgaaggcgagtgcaatgtcatgctggaatcccgc
tttgagaagatgtatgagaagatcgacttgactctgctcaacaggctgctgcgcctcatc
gtggaccacaacatagccgactacatgacagccaagaacaacgtcgtcatcaactataag
gacatgaaccatacgaattcatatgggatcatcagaggcctgcagtttgcctcattcatc
gtgcagtattatggcctggtgatggatttgcttgtattgggattgcaccgggccagtgag
atggctgggccccctcagatgccaaatgactttctcagtttccaggacatagccactgag
gctgcccaccccatccgtctcttctgcagatacattgatcgcatccatatttttttcagg
ttcacagcagatgaggctcgggacctgattcaacgttacctgacagagcaccctgacccc
aataatgaaaacatcgttggctataataacaagaagtgctggccccgagatgcccgcatg
cgcctcatgaaacatgatgttaacttaggccgggcggtattctgggacatcaagaaccgc
ttgccacggtcagtgactacagttcagtgggagaacagcttcgtgtctgtgtacagtaag
gacaaccccaacctgctgttcaacatgtgtggcttcgagtgccgcatcctgcctaagtgc
cgcaccagctatgaggagttcacccacaaggacggggtctggaacctgcagaatgaggtt
actaaggagcgcacagctcagtgtttcctgcgtgtggacgatgagtcaatgcagcgcttc
cacaaccgcgtgcgtcagattctcatggcctctgggtccaccaccttcaccaagattgtg
aataagtggaatacagctctcattggccttatgacatactttcgggaggctgtggtgaac
acccaagagctcttggacttactggtgaagtgtgagaacaaaatccagacacgtatcaag
attggactcaactccaagatgccaagtcggttccccccggttgtgttctacacccctaag
gagttgggtggactcggcatgctctcaatgggccatgtgctcatcccccaatccgacctc
aggtggtccaaacagacagatgtaggtatcacacactttcgttcaggaatgagccatgaa
gaagaccagctcattcccaacttgtaccgctacatacagccatgggagagcgagttcatt
gattctcagcgggtctgggctgagtacgcactcaagaggcaagaggccattgctcagaac
agacgcctgactttagaagacctagaagattcatgggatcgtggcattcctcgaatcaat
accctcttccagaaggaccggcacacactggcttatgataagggctggcgtgtcagaact
gactttaagcagtatcaggttttgaagcagaatccgttctggtggacacaccagcggcat
gatgggaagctctggaacctgaacaactaccgtacagacatgatccaggccctgggcggt
gtggaaggcattctggaacacacactctttaagggcacttacttccctacctgggagggg
cttttctgggagaaggccagtggctttgaggaatctatgaagtggaagaagctaactaat
gctcagcgatcaggactgaaccagattcccaatcgtagattcaccctctggtggtccccg
accattaatcgagccaatgtatatgtaggctttcaggtgcagctagacctgacgggtatc
ttcatgcacggcaagatccccacgctgaagatctctctcatccagatcttccgagctcac
ttgtggcagaagatccatgagagcattgttatggacttatgtcaggtgtttgaccaggaa
cttgatgcactggaaattgagacagtacaaaaggagacaatccatccccgaaagtcatat
aagatgaactcttcctgtgcagatatcctgctctttgcctcctataagtggaatgtctcc
cggccctcattgctggctgactccaaggatgtgatggacagcaccaccacccagaaatac
tggattgacatccagttgcgctggggggactatgattcccacgacattgagcgctacgcc
cgggccaagttcctggactacaccaccgacaacatgagtatctacccttcgcccacaggt
gtactcatcgccattgacctggcctataacttgcacagtgcctatggaaactggttccca
ggcagcaagcctctcatacaacaggccatggccaagatcatgaaggcaaaccctgccctg
tatgtgttacgtgaacggatccgcaaggggctacagctctattcatctgaacccactgag
ccttatttgtcttctcagaactatggtgagctcttctccaaccagattatctggtttgtg
gatgacaccaacgtctacagagtgactattcacaagacctttgaagggaacttgacaacc
aagcccatcaacggagccatcttcatcttcaacccacgcacagggcagctgttcctcaag
ataatccacacgtccgtgtgggcgggacagaagcgtttggggcagttggctaagtggaag
acagctgaggaggtggccgccctgatccgatctctgcctgtggaggagcagcccaagcag
atcattgtcaccaggaagggcatgctggacccactggaggtgcacttactggacttcccc
aatattgtcatcaaaggatcggagctccaactccctttccaggcgtgtctcaaggtggaa
aaattcggggatctcatccttaaagccactgagccccagatggttctcttcaacctctat
gacgactggctcaagactatttcatcttacacggccttctcccgtctcatcctgattctg
cgtgccctacatgtgaacaacgatcgggcaaaagtgatcctgaagccagacaagactact
attacagaaccacaccacatctggcccactctgactgacgaagaatggatcaaggtcgag
gtgcagctcaaggatctgatcttggctgactacggcaagaaaaacaatgtgaacgtggca
tcactgacacaatcagaaattcgagacatcatcctgggtatggagatctcggcaccgtca
cagcagcggcagcagatcgctgagatcgagaagcagaccaaggaacaatcgcagctgacg
gcaacacagactcgcactgtcaacaagcatggcgatgagatcatcacctccaccaccagc
aactatgagacccagactttctcatccaagactgagtggagggtcagggccatctctgct
gccaacctgcacctaaggaccaatcacatctatgtttcatctgacgacatcaaggagact
ggctacacctacatccttcccaagaatgtgcttaagaagttcatctgcatatctgacctt
cgggcccaaattgcaggatacctatatggggtgagcccaccagataacccccaggtgaag
gagatccgctgcattgtgatggtgccgcagtggggcactcaccagaccgtgcacctgcct
ggccagctgccccagcatgagtacctcaaggagatggaacccttaggttggatccacact
cagcccaatgagtccccgcagttatcaccccaggatgtcaccacccatgccaagatcatg
gctgacaacccatcttgggatggcgagaagaccattatcatcacatgcagcttcacgcca
ggctcctgtacactgacggcctacaagctgacccccagtggctacgaatggggccgccag
aacacagacaagggcaacaaccccaagggctacctgccttcacactatgagagggtgcag
atgctgctgtcggaccgtttccttggcttcttcatggtccctgcccagtcctcgtggaac
tacaacttcatgggtgttcggcatgaccccaacatgaaatatgagctacagctggcgaac
cccaaagagttctaccacgaggtgcacaggccctctcacttcctcaactttgctctcctg
caggagggggaggtttactctgcggatcgggaggacctgtatgcctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (298)   
   KEGG ORTHOLOGY (1)   
   RefGene (290)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (30)   
   RefSeq(nuc) (4)   
   GenBank (13)   
   EMBL (13)   
3D Structure (64)   
   PDB (64)   
Protein domain (8)   
   Pfam (8)   
All databases (413)   

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