KEGG   Homo sapiens (human): 10721
Entry
10721             CDS       T01001                                 
Symbol
POLQ, PRO0327
Name
(RefSeq) DNA polymerase theta
  KO
K02349  DNA polymerase theta [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    10721 (POLQ)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     10721 (POLQ)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   DNA polymerases
    10721 (POLQ)
SSDB
Motif
Pfam: DNA_pol_A POLQ_helical HTH_61 DEAD Helicase_C ResIII Helicase_dom4_arc DUF4332 HHH_5
Other DBs
NCBI-GeneID: 10721
NCBI-ProteinID: NP_955452
OMIM: 604419
HGNC: 9186
Ensembl: ENSG00000051341
UniProt: O75417 Q59EE4
Structure
Position
3:complement(121431431..121545988)
AA seq 2590 aa
MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR
KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
SWGELKDFDV
NT seq 7773 nt   +upstreamnt  +downstreamnt
atgaatcttctgcgtcggagtgggaaacggcggcgttcagaatcaggctcagattcgttc
tcgggaagcggcggtgacagcagtgccagcccccagttcctctccgggtccgtgctgagc
ccgccgcccggccttggtcgctgcctgaaggccgcagctgcaggagaatgcaagcctaca
gttcctgactacgaaagagacaagctactattggcaaactggggacttcctaaagcagtt
ctggaaaaataccacagttttggtgtaaaaaagatgtttgaatggcaggcagagtgcctt
ttgcttggacaagtcctggaaggaaagaatttagtttattcagctcctacaagtgctggg
aagactcttgtggcagaattacttattttgaagcgggttttggaaatgcggaagaaagct
ttgtttattcttccctttgtttctgtggctaaagagaagaaatactacctccagagtctg
tttcaggaagtaggaataaaagtagacggttatatgggcagcacctctccatcaaggcat
ttctcttcattggatattgcagtctgcacaattgagagagccaatggtctgatcaatcgc
ctcatagaggaaaataagatggatctgttaggaatggtggttgtggatgaattacatatg
ctgggagactctcaccgagggtatctgctggaacttttgctgaccaagatttgctatatt
actcggaaatcagcatcttgtcaggcagatctagccagttctctgtctaatgctgtgcaa
atcgttggcatgagtgctacccttcctaatttggagcttgtggcttcctggttgaatgct
gaactctaccataccgactttcgccctgtaccgcttttggagtcagtaaaagttggaaat
tccatatatgactcttcaatgaaacttgtgagggaatttgagcccatgctacaagtgaag
ggagatgaggaccatgttgttagtttatgttatgagacgatttgtgataaccattcagta
ttacttttttgtccatcaaagaaatggtgtgagaagctggcagatatcattgctcgagag
ttttataatctacatcatcaagctgagggattggtgaaaccctctgaatgcccaccagta
attctggaacaaaaagaactcctggaagtgatggatcagttaagacgtttgccttcagga
ctggactctgtattacagaaaactgtaccatggggagtagcatttcatcatgcaggtctt
acttttgaggagagggatatcattgaaggagcctttcgtcaaggtctcattcgggtcttg
gcggcaacttctactctttcttctggggtgaatttacctgcacgtcgtgtgattattcga
acccctatttttggtggtcgacctctagatattcttacttataagcagatggttggccgt
gctggcaggaaaggagtggacacagtaggcgagagtatcttaatttgtaagaactctgag
aaatcaaaaggcatagctctccttcagggttctctaaagcctgttcgcagctgtctgcaa
agacgagaaggagaagaagtaactggcagcatgatacgagctattctggagataatagtt
ggtggagtggcaagtacatcacaagatatgcatacttatgctgcctgcacatttttggct
gcaagtatgaaagaagggaagcaaggaattcagagaaatcaagagtctgttcagcttgga
gcgattgaggcctgtgtgatgtggctactagaaaatgaattcatccagagtacagaagcc
agtgatggaacagaaggaaaggtgtatcatccaacacatcttggttcggccactctttct
tcttcactttctccagctgatactttagatatttttgctgacctgcaaagagcaatgaag
ggctttgttttagagaatgatcttcatattctctatctggttacacctatgtttgaggat
tggactactattgattggtatcgatttttctgtttatgggagaagttgccaacttcaatg
aaaagggtggcagagctagtgggagttgaagaggggttcttggcccgttgtgtgaaagga
aaagtagtagccagaactgagagacagcatcgacaaatggccatccataaaaggtttttc
accagtcttgtgctattagatttaatcagtgaagttcccttaagggaaataaatcagaaa
tatggatgcaatcgtgggcagattcaatctttgcaacagtcagctgctgtttatgcaggg
atgattacagtattttccaaccgtctgggctggcacaacatggaactactactttcccaa
tttcagaagcgtcttacgtttggcatccagagggagctgtgtgacctggttcgggtatcc
ttactaaatgctcagagagccagggttctctatgcttctggctttcatactgtggcagac
cttgctagagcaaatattgtggaggtggaggtgattctgaaaaatgctgtgcctttcaaa
agtgcccggaaggcagtggatgaggaagaggaagcagttgaagaacgtcgcaatatgcga
actatctgggtgactggcagaaaaggtttaactgaaagggaagcagcagcccttatagtg
gaagaagccagaatgattctgcagcaggacttagttgaaatgggagtgcaatggaatcca
tgtgccctgttacattctagtacatgctcattgactcatagtgagtccgaagtaaaggaa
cacacatttatatcccaaactaagagttcttataaaaaattaacatcaaagaacaaaagt
aacacaatatttagtgattcttatattaagcattcaccaaatatagtgcaagacttaaat
aaaagtagagagcatacaagttcctttaattgtaatttccagaatgggaatcaagaacat
cagacatgttccattttcagagcaagaaaacgggcctctttagatataaataaagagaag
ccaggagcctctcagaatgaggggaaaacaagtgataagaaagttgttcagactttttca
cagaaaacaaaaaaggcacctttgaatttcaattcagaaaagatgagcagaagttttcga
tcttggaaacgtagaaagcatctaaagcgatctagggacagcagccccctgaaagactct
ggagcgtgtagaatccatttacaaggacagactctgtctaatcctagtctttgtgaagac
ccgtttaccttagatgagaagaaaacggaatttagaaattcagggccatttgctaaaaat
gtatctttgagtggtaaggaaaaagataataaaacatcattcccattacaaataaagcaa
aattgttcatggaacataacactaactaatgataattttgtggagcatattgtcacagga
tctcagagtaaaaatgtgacttgtcaggccactagtgtggttagtgaaaagggcagagga
gtagctgttgaggcagaaaaaataaatgaagtgctgatacaaaatggttcaaaaaaccag
aatgtttatatgaaacaccatgacatccatccaattaaccagtacctgcgaaagcaatct
catgaacagacaagcactattaccaaacagaaaaatataatagagagacaaatgccctgt
gaagcagtcagtagttacataaatagagactcaaatgttactatcaattgtgaaaggata
aagcttaatacagaggaaaataaaccaagtcattttcaggcattaggagatgatataagc
agaactgtgatacccagtgaagtacttccatcagctggagcatttagcaaatcagaaggc
cagcatgagaattttctaaatatttctagactacaagaaaaaacaggtacttatacaaca
aacaaaactaaaaataatcatgtttctgacttaggtttagtcctctgtgattttgaagat
agtttctatctggatactcagtcagagaaaataatacaacagatggcaactgaaaatgcc
aaactaggagcaaaggacaccaacctggcagcagggataatgcagaagagcttagtccaa
cagaactcaatgaactcttttcagaaggagtgtcacattccttttcctgctgaacagcac
cctctaggagcgactaagatagatcatttggaccttaagactgtaggtactatgaaacaa
agcagtgattcacatggggttgatatcctgactccagaaagcccgattttccattctcca
atactattggaggaaaatggtctttttttaaaaaagaatgaagtttctgttactgattca
caattaaatagttttcttcaaggttatcaaacacaagaaactgtgaaaccagttatactt
ctgattcctcaaaagagaactcccactggtgtagaaggagaatgtcttccagttcctgaa
acaagtttgaatatgagtgatagtttactatttgatagcttcagtgatgactatctagta
aaagaacaattacctgatatgcaaatgaaagaaccccttccttcagaagtaacatcaaac
cattttagtgattctctgtgtctacaagaagacctaattaaaaaatcaaatgtaaatgag
aatcaagatacccaccagcagttgacttgttccaatgatgaatctattatattttcagaa
atggattctgttcagatggttgaagctttggacaatgtggatatatttcctgtccaagag
aagaatcatactgtagtatctcctagagcattagaactaagtgatccagtacttgatgag
caccaccaaggtgatcaagatggaggagatcaagatgaaagggctgaaaaatcaaaatta
actgggaccaggcaaaatcattcattcatatggtcaggggcatcatttgatctaagtcca
ggactgcaaaggattttagataaagtatccagtcctctagaaaatgaaaagctaaaatca
atgactataaacttttccagtttgaatagaaaaaatacagagttaaatgaagaacaagaa
gttatttcaaacttggagacaaaacaagtgcagggaatttcattttcttctaataatgaa
gtaaaaagcaagattgagatgctagaaaacaatgccaatcatgatgaaacctcatccctc
ttacctcgtaaagaaagtaatatagttgatgataatggtctcattcctcctacacccatt
ccaacatctgcttctaagctgacatttccagggattcttgaaacacctgtaaacccttgg
aaaactaataatgttttacaacctggtgaaagttatttatttggctcaccttcagatatt
aaaaaccacgatttaagtccagggagtagaaatgggttcaaagacaacagccctattagt
gacacaagcttttcacttcagttatcacaggatggattacagttaactccagcctcaagc
agttcagaaagtttgtccataattgatgtagcaagtgaccaaaatcttttccaaacattc
attaaggagtggcggtgcaaaaagcgattttccatctcactggcttgtgaaaagattaga
agtttgacatcttctaaaactgctactattggcagtaggtttaagcaagctagctcacct
caggaaattcctattagagatgatggatttcccattaaaggttgtgatgacaccttggtg
gttggactggcagtatgctggggtggaagggatgcctattatttttcactgcagaaggaa
caaaagcattctgaaattagtgccagtttggttccaccttctttagatccaagcctgact
ttgaaagacaggatgtggtaccttcaatcttgcttgcgaaaggaatctgataaagaatgt
tctgttgtcatctatgacttcatccagagctataaaattcttcttctttcttgtggcatc
tccttggagcaaagttatgaagatcctaaggtggcatgctggttactagatccagattct
caggagccgactcttcatagcatagttaccagttttcttcctcatgagcttccactccta
gaagggatggagaccagccaagggattcaaagcctggggctaaatgctggcagtgagcat
tctgggcgatacagagcatctgtggagtccattctcatcttcaactctatgaatcagctc
aactctttgttgcagaaggaaaaccttcaagatgttttccgtaaggtggaaatgccctct
cagtactgcttggccttgctagaactaaatggaattggctttagtactgcagaatgtgaa
agtcagaaacatataatgcaagccaagctggatgcaattgagacccaggcctatcaacta
gctggccacagtttttctttcaccagttcagatgacatcgctgaggttttatttttggaa
ttgaagttgcccccaaatagagagatgaaaaaccaaggcagcaagaaaactctgggttct
accagaagagggattgacaatggacgcaagctaaggctgggaagacagttcagcactagt
aaggacgttttaaataaattaaaggcattacatcctttaccaggcttgatattagaatgg
agaagaatcactaatgctattaccaaagtggtctttccccttcagcgggaaaagtgtctt
aatccttttcttggaatggaaagaatctatcctgtatcacagtcgcacactgctacagga
cgaataacctttacagaaccaaatattcagaatgtgccaagagattttgaaatcaaaatg
ccaacactagtaggagaaagcccaccttctcaagctgtaggcaaaggcctacttcccatg
ggcagaggaaaatataagaagggtttcagcgtgaatcctagatgccaggcacagatggag
gagagagctgcagacagaggaatgccattttcaattagcatgcgacatgcctttgtgcct
ttcccaggtggttcaatactggctgctgactactctcagcttgaactgaggatcttggct
catttatcccatgatcgtcgtctcattcaagtgttaaacactggagctgatgttttcagg
agcattgcagcagagtggaagatgattgagccagagtctgttggggatgatctgaggcag
caggcaaaacagatttgctatgggatcatttatggaatgggagctaaatctttgggagag
cagatgggcattaaagaaaatgatgctgcatgctatattgactccttcaaatccagatac
acagggattaatcaattcatgacagagacagtgaagaattgtaaaagagacggatttgtt
cagaccattttgggaaggcgtagatatttgccaggaatcaaagacaacaacccttatcgt
aaagctcacgctgagcgtcaagctatcaacacaatagtccaaggatcagcagctgatatt
gtcaaaatagccacagttaacattcagaagcaattagagaccttccactcaaccttcaaa
tcccatggtcatcgagagggtatgctccaaagtgaccaaacaggattgtcacgaaagaga
aaactgcaagggatgttctgcccaatcagaggaggcttcttcatccttcaactccatgat
gaactcctatatgaagtggcagaagaagatgttgttcaggtagctcagattgtcaagaat
gaaatggaaagtgctgtaaaactgtctgtgaaattgaaagtgaaagtgaaaataggcgcc
agctggggagagctaaaggactttgatgtgtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (11)   
   PDB (11)   
Protein domain (9)   
   Pfam (9)   
All databases (91)   

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