KEGG   Homo sapiens (human): 1119
Entry
1119              CDS       T01001                                 
Symbol
CHKA, CHK, CK, CKI, EK, NEDMIMS
Name
(RefSeq) choline kinase alpha
  KO
K14156  choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa01100  Metabolic pathways
hsa05231  Choline metabolism in cancer
Module
hsa_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC
hsa_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
Disease
H02461  Neurodevelopmental disorder with microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    1119 (CHKA)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    1119 (CHKA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.32  choline kinase
     1119 (CHKA)
    2.7.1.82  ethanolamine kinase
     1119 (CHKA)
SSDB
Motif
Pfam: Choline_kinase APH EcKL Kdo Pkinase_fungal
Other DBs
NCBI-GeneID: 1119
NCBI-ProteinID: NP_001268
OMIM: 118491
HGNC: 1937
Ensembl: ENSG00000110721
UniProt: P35790
Structure
Position
11:complement(68052859..68121388)
AA seq 457 aa
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
NT seq 1374 nt   +upstreamnt  +downstreamnt
atgaaaaccaaattctgcaccgggggcgaggcggagccctcgccgctcgggctgctgctg
agctgcggtagcggcagcgcggccccggcgcccggcgtggggcagcagcgcgacgccgcc
agcgacctcgagtccaagcagctgggcggccaacagccgccgctcgcgctgccccctccg
ccgccgctgccgctgccgctgccgctgccccagcccccgccgccgcagccgcccgcagac
gagcagccggagccccggacgcggcgcagggcctatctgtggtgcaaggagttcctgccc
ggcgcctggcggggcctccgcgaggacgagttccacatcagtgtcatcagaggcggcctt
agcaacatgctgttccagtgctccctacctgacaccacagccacccttggtgatgagcct
cggaaagtgctcctgcggctgtatggagcgattttgcagatgaggtcctgtaataaagag
ggatccgaacaagctcagaaagaaaatgaatttcaaggggctgaggccatggttctggag
agcgttatgtttgccattctcgcagagaggtcacttgggccaaaactctatggcatcttt
ccccaaggccgactggagcagttcatcccgagccggcgattagatactgaagaattaagt
ttgccagatatttctgcagaaatcgccgagaaaatggctacatttcatggtatgaaaatg
ccattcaataaggaaccaaaatggctttttggcacaatggaaaagtatctaaaggaagtg
ctgagaattaaatttactgaggaatccagaattaaaaagctccacaaattgctcagttac
aatctgcccttggaactggaaaacctgagatcattgcttgaatctactccatctccagtt
gtattttgtcataatgactgtcaagaaggtaatatcttgttgctggaaggccgagagaat
tctgaaaaacagaaactgatgctcattgatttcgaatacagcagttacaattacagggga
ttcgacattggaaatcacttctgtgagtggatgtatgattatagctatgaaaaataccct
tttttcagagcaaacatccggaagtatcccaccaagaaacaacagctccattttatttcc
agttacttgcctgcattccaaaatgactttgaaaacctcagtactgaagaaaaatccatt
ataaaagaagaaatgttgcttgaagttaataggtttgcccttgcatctcatttcctctgg
ggactgtggtccattgtacaagccaagatttcatctattgaatttgggtacatggactac
gcccaagcaaggtttgatgcctatttccaccagaagaggaagcttggggtgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (22)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (45)   
   RefSeq(nuc) (23)   
   GenBank (11)   
   EMBL (11)   
3D Structure (26)   
   PDB (26)   
Protein domain (5)   
   Pfam (5)   
All databases (129)   

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