KEGG   Homo sapiens (human): 115752
Entry
115752            CDS       T01001                                 
Symbol
DIS3L, DIS3L1
Name
(RefSeq) DIS3 like exosome 3'-5' exoribonuclease
  KO
K18681  DIS3-like exonuclease 1 [EC:3.1.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    115752 (DIS3L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    115752 (DIS3L)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    Exosome cofactors
     115752 (DIS3L)
SSDB
Motif
Pfam: RNB OB_Dis3 Rrp44_CSD1 CSD2 Rrp44_S1
Other DBs
NCBI-GeneID: 115752
NCBI-ProteinID: NP_001137160
OMIM: 614183
HGNC: 28698
Ensembl: ENSG00000166938
UniProt: Q8TF46
Position
15:66293309..66333898
AA seq 1054 aa
MLQKREKVLLLRTFQGRTLRIVREHYLRPCVPCHSPLCPQPAACSHDGKLLSSDVTHYVI
PDWKVVQDYLEILEFPELKGIIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCILFANE
FQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPIVMVTEDEEAIQQYGSETEGV
FVITFKNYLDNFWPDLKAAHELCDSILQSRRERENESQESHGKEYPEHLPLEVLEAGIKS
GRYIQGILNVNKHRAQIEAFVRLQGASSKDSDLVSDILIHGMKARNRSIHGDVVVVELLP
KNEWKGRTVALCENDCDDKASGESPSEPMPTGRVVGILQKNWRDYVVTFPSKEEVQSQGK
NAQKILVTPWDYRIPKIRISTQQAETLQDFRVVVRIDSWESTSVYPNGHFVRVLGRIGDL
EGEIATILVENSISVIPFSEAQMCEMPVNTPESPWKVSPEEEQKRKDLRKSHLVFSIDPK
GCEDVDDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDIEARTRATTYYLADRRYDMLP
SVLSADLCSLLGGVDRYAVSIMWELDKASYEIKKVWYGRTIIRSAYKLFYEAAQELLDGN
LSVVDDIPEFKDLDEKSRQAKLEELVWAIGKLTDIARHVRAKRDGCGALELEGVEVCVQL
DDKKNIHDLIPKQPLEVHETVAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSEL
RECAKAKGFFIDTRSNKTLADSLDNANDPHDPIVNRLLRSMATQAMSNALYFSTGSCAEE
EFHHYGLALDKYTHFTSPIRRYSDIVVHRLLMAAISKDKKMEIKGNLFSNKDLEELCRHI
NNRNQAAQHSQKQSTELFQCMYFKDKDPATEERCISDGVIYSIRTNGVLLFIPRFGIKGA
AYLKNKDGLVISCGPDSCSEWKPGSLQRFQNKITSTTTDGESVTFHLFDHVTVRISIQAS
RCHSDTIRLEIISNKPYKIPNTELIHQSSPLLKSELVKEVTKSVEEAQLAQEVKVNIIQE
EYQEYRQTKGRSLYTLLEEIRDLALLDVSNNYGI
NT seq 3165 nt   +upstreamnt  +downstreamnt
atgctgcagaagcgggagaaggtgctgctgctgaggaccttccagggccgcacgctgcgg
atcgtgcgcgagcactacctgcggccctgcgtgccctgccacagcccgctctgcccgcag
cccgccgcctgcagccacgatgggaaactcttgtctagtgatgtgactcattacgtgatc
ccagactggaaagttgttcaagattatcttgagatccttgagtttcctgagttgaaggga
attattttcatgcagacagcttgtcaagctgtgcagcatcaaagaggcaggagacagtat
aacaaactgcgaaacctgctgaaggatgcgcgtcatgattgcattctctttgctaatgaa
ttccagcaatgctgctatctgccacgggaaagaggagagtccatggagaagtggcagacc
aggagcatatacaacgcagctgtttggtactatcatcactgccaggacaggatgccaatt
gttatggtgacagaagatgaagaggcaattcagcagtatggaagtgaaacagaaggagta
ttcgtgattactttcaagaattacctggacaatttctggcctgatttaaaagctgcccac
gagctttgtgattctatccttcagtctcgacgggagagagagaatgagagtcaggagagc
catgggaaggagtacccagaacatcttcccctggaagtgttagaagctgggattaaatct
ggacgctatatccagggaattctgaatgtcaacaaacacagagcccaaatagaagctttt
gttcgacttcaaggagccagcagtaaagattcagatttagtcagtgacatcctaatccac
gggatgaaggctcgaaaccgctcaattcatggagatgtggtagttgtggagctgcttcct
aaaaatgaatggaaaggaagaaccgtagccctgtgtgagaatgactgtgacgacaaggct
tcgggcgagtccccaagtgagcccatgcctacaggtcgagtggtgggcatacttcagaag
aactggcgggattatgtggtgacatttccgtccaaagaagaggtccaatctcagggcaaa
aatgctcagaaaatcctggttacaccttgggattacagaattcccaaaattcgaattagc
actcagcaagcagaaaccctccaggacttcagggtggtcgtgcgcatcgattcctgggag
tcaacatctgtgtatccaaatggacattttgtgcgtgttttaggaagaatcggagatctg
gaaggggaaattgcaaccatcctggtggaaaacagtatttcagttattcctttctcagaa
gctcagatgtgtgagatgccagtaaacacaccagaaagtccctggaaggtgagtcctgaa
gaggaacaaaaacgtaaagacttgaggaaaagccatctcgtattcagcattgaccccaaa
ggttgtgaagatgtggatgacacactctcagtcagaaccttaaataatggcaacctggaa
cttggggtccacatcgcagatgtaacacactttgtggcaccaaattcttacattgatatt
gaagctagaacaagggccaccacttattatctagcagatcgtcgctatgacatgctgcct
tccgtcctcagtgcagatttgtgttcccttctgggaggcgttgataggtatgctgtaagc
atcatgtgggaactggataaagcctcttatgaaattaagaaagtgtggtatggcagaacc
attattcgatcagcatacaaactgttctatgaagcagcccaagaactactggatggaaac
ttaagcgttgttgatgatattccagaattcaaagacttggatgagaagagcagacaagcc
aagctggaggagttggtgtgggcaattggaaagctgaccgacatagctcgccatgtcaga
gctaaacgagacggatgtggtgccctggaactggaaggggtagaggtttgcgtacagcta
gatgacaaaaagaacattcacgacctcatccccaagcagcccctggaagtccacgagaca
gtggctgaatgcatgatcctggccaaccactgggtcgccaaaaagatctgggagagcttc
cctcatcaggccttgctgcgccagcaccctcctccacaccaggagttcttttcagaactc
cgggaatgtgctaaagccaaaggcttcttcatagatacacggtccaataaaacactggct
gattctctggataatgcgaacgacccccacgatcccattgtgaacaggctactgcgctcc
atggccacgcaggccatgtcgaatgctctgtacttctccaccggatcctgtgcggaggag
gagttccatcattacggtcttgcattagataaatatacccactttacttctccaataaga
agatattcagatattgtagtacaccgcttgttaatggcagccatttcaaaagataagaaa
atggaaattaagggaaatctgttcagcaacaaagatcttgaggaattatgcagacatatc
aacaacagaaaccaagcagcacagcattctcagaagcagtctactgagctcttccagtgc
atgtacttcaaagacaaagaccctgccaccgaggagcgttgcatatctgacggagttatt
tattcaattagaacaaatggtgtgcttctatttataccaaggtttgggattaaaggtgct
gcttatctaaaaaataaagatggtttagtcatctcatgtggcccagatagctgttctgaa
tggaaaccaggatcccttcaacgatttcaaaacaaaattacctctactacaacagatggg
gaatctgttacgttccatttgtttgaccatgtaaccgtaagaatatccatacaggcctca
cgttgccattctgatacaatcagacttgaaataattagtaacaaaccatacaagatacca
aatacagaacttattcatcagagttcccccttgctgaagagtgagttagtgaaagaagta
actaaatctgtggaagaagctcagcttgcccaagaagtcaaagtaaacatcattcaggag
gaatatcaagaatatcgccaaacaaagggaaggagcctatacacacttctagaggagata
cgggacctagctctcctggatgtttcaaacaattatggaatatga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (35)   
   RefSeq(nuc) (15)   
   GenBank (10)   
   EMBL (10)   
Protein domain (5)   
   Pfam (5)   
All databases (84)   

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