KEGG T01001: 148

Homo sapiens (human): 148

Entry

148               CDS       T01001

Symbol

ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR

Name

(RefSeq) adrenoceptor alpha 1A

K04135

adrenergic receptor alpha-1A

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04152

AMPK signaling pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04270

Vascular smooth muscle contraction

hsa04970

Salivary secretion

Network

nt06528 Calcium signaling

Element

N01640

GPCR-PLCB-ITPR signaling pathway

Drug target

Adrenalone (DG00016):

D02774 D07560

Alfuzosin (DG00489):

D01692<US> D07124

Amidephrine mesylate:

D02901

Amiodarone (DG00204):

D00636<JP/US> D02910

Amosulalol (DG01302):

D01469<JP> D07451

Arotinolol (DG01303):

D01830<JP> D07465

Bevantolol:

D01369<JP>

Bunazosin (DG01316):

D01887<JP> D07550

Bunitrolol hydrochloride:

D01444

Carvedilol (DG00321):

D00255<JP/US> D03415<US>

Dabuzalgron hydrochloride:

D06394

Dapiprazole (DG01140):

D03648<US> D07775

Dihydroergocristine (DG00284):

D07833 D07834

Dipivefrine (DG01129):

D01017 D02349

Domazoline fumarate:

D03887

Doxazosin (DG00256):

D00608<JP/US> D07874

Dronedarone (DG00207):

D02537 D03914<US>

Droperidol:

D00308<JP/US>

Droxidopa:

D01277<JP/US>

Ephedrine (DG00227):

D00124 D01386<JP/US> D04018<US>

Epinephrine (DG00013):

D00095<JP/US> D00996 D02149

Epinephryl borate:

D04026

Ergoloid mesylates:

D02268

Ergometrine (DG00446):

D01163 D07905

Ergot alkaloids:

D07906

Ergotamine (DG00834):

D00679<US>

Etilefrine (DG00210):

D01573<JP> D07931

Fiduxosin hydrochloride:

D04184

Flesinoxan:

D02568

Garomefrine hydrochloride:

D09784

Guanadrel:

D08029

Guanadrel sulfate:

D00607

Ifenprodil (DG00292):

D01445<JP> D08064

Indoramin (DG00254):

D04531 D04532

Isometheptene:

D07097

Labetalol (DG00320):

D00600<JP/US> D08106

Levobunolol (DG01136):

D01025<JP/US> D08115

Metaraminol (DG00218):

D01019 D08192

Methoxamine (DG00219):

D01020 D08201

Methylephedrine (DG01229):

D01952 D02109<JP> D08206 D09842

Methylergometrine (DG00445):

D00680<JP/US> D08207

Midodrine (DG00224):

D01307<JP/US> D08220

Monatepil maleate:

D01171

Moxisylyte (DG00287):

D01571 D08239

Naftopidil:

D01674<JP>

Naphazoline (DG01032):

D00743 D01021<JP> D08253

Nefazodone (DG00953):

D00819<US> D08257

Nicergoline (DG00283):

D01290<JP> D08271

Nipradilol:

D01691<JP>

Norepinephrine (DG00212):

D00076<JP> D05206<US> D08284 D09794

Norfenefrine (DG00214):

D01405 D08286

Octodrine:

D05228

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Oxymetazoline (DG01029):

D01022<US> D08322

Pelanserin hydrochloride:

D05395

Periciazine:

D01485<JP>

Phenoxybenzamine (DG00285):

D00507<US> D08358

Phentolamine (DG00280):

D00509<JP/US> D08362

Phenylephrine (DG00215):

D00511<JP/US> D08365 D08366 D08966

Phenylpropanolamine (DG01041):

D01224 D05466 D08368

Prazosin (DG00253):

D00609<JP/US> D08411

Propylhexedrine (DG01919):

D05637 D08444

Pseudoephedrine (DG01042):

D00485 D05648 D05649 D08449

Racephedrine hydrochloride:

D08982

Racepinephrine (DG01444):

D05688 D05689

Silodosin:

D01965<JP/US>

Tamsulosin (DG00490):

D01024<JP/US> D08560

Terazosin (DG00491):

D00610<JP/US> D08569 D11585<US>

Tetryzoline (DG01030):

D00756 D01023 D08578

Tolazoline (DG00281):

D00997 D08614

Tramazoline (DG01033):

D01347<JP> D08624

Trimazosin (DG00255):

D06234 D08212

Urapidil (DG00257):

D01333<JP> D08662

Xylometazoline (DG01031):

D00757 D08684

Zolertine hydrochloride:

D06380

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    148 (ADRA1A)
   04022 cGMP-PKG signaling pathway
    148 (ADRA1A)
   04152 AMPK signaling pathway
    148 (ADRA1A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    148 (ADRA1A)
09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    148 (ADRA1A)
   04270 Vascular smooth muscle contraction
    148 (ADRA1A)
  09154 Digestive system
   04970 Salivary secretion
    148 (ADRA1A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    148 (ADRA1A)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Adrenaline
    148 (ADRA1A)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 DUF4407

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

8:complement(26748150..26867379)

AA seq 466 aa
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV

NT seq 1401 nt +upstreamnt +downstreamnt
atggtgtttctctcgggaaatgcttccgacagctccaactgcacccaaccgccggcaccg
gtgaacatttccaaggccattctgctcggggtgatcttggggggcctcattcttttcggg
gtgctgggtaacatcctagtgatcctctccgtagcctgtcaccgacacctgcactcagtc
acgcactactacatcgtcaacctggcggtggccgacctcctgctcacctccacggtgctg
cccttctccgccatcttcgaggtcctaggctactgggccttcggcagggtcttctgcaac
atctgggcggcagtggatgtgctgtgctgcaccgcgtccatcatgggcctctgcatcatc
tccatcgaccgctacatcggcgtgagctacccgctgcgctacccaaccatcgtcacccag
aggaggggtctcatggctctgctctgcgtctgggcactctccctggtcatatccattgga
cccctgttcggctggaggcagccggcccccgaggacgagaccatctgccagatcaacgag
gagccgggctacgtgctcttctcagcgctgggctccttctacctgcctctggccatcatc
ctggtcatgtactgccgcgtctacgtggtggccaagagggagagccggggcctcaagtct
ggcctcaagaccgacaagtcggactcggagcaagtgacgctccgcatccatcggaaaaac
gccccggcaggaggcagcgggatggccagcgccaagaccaagacgcacttctcagtgagg
ctcctcaagttctcccgggagaagaaagcggccaaaacgctgggcatcgtggtcggctgc
ttcgtcctctgctggctgccttttttcttagtcatgcccattgggtctttcttccctgat
ttcaagccctctgaaacagtttttaaaatagtattttggctcggatatctaaacagctgc
atcaaccccatcatatacccatgctccagccaagagttcaaaaaggcctttcagaatgtc
ttgagaatccagtgtctctgcagaaagcagtcttccaaacatgccctgggctacaccctg
cacccgcccagccaggccgtggaagggcaacacaaggacatggtgcgcatccccgtggga
tcaagagagaccttctacaggatctccaagacggatggcgtttgtgaatggaaatttttc
tcttccatgccccgtggatctgccaggattacagtgtccaaagaccaatcctcctgtacc
acagcccgggtgagaagtaaaagctttttgcaggtctgctgctgtgtagggccctcaacc
cccagccttgacaagaaccatcaagttccaaccattaaggtccacaccatctccctcagt
gagaacggggaggaagtctag

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