| Entry |
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| Symbol |
DLD, DLDD, DLDH, E3, GCSL, LAD, OGDC-E3, PHE3
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| Name |
(RefSeq) dihydrolipoamide dehydrogenase
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| KO |
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| Organism |
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| Pathway |
| hsa00260 | Glycine, serine and threonine metabolism |
| hsa00280 | Valine, leucine and isoleucine degradation |
| hsa00630 | Glyoxylate and dicarboxylate metabolism |
| hsa01210 | 2-Oxocarboxylic acid metabolism |
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| Module |
| hsa_M00011 | Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate |
| hsa_M00032 | Lysine degradation, lysine => saccharopine => acetoacetyl-CoA |
| hsa_M00036 | Leucine degradation, leucine => acetoacetate + acetyl-CoA |
| hsa_M00307 | Pyruvate oxidation, pyruvate => acetyl-CoA |
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| Network |
nt06024 Valine, leucine and isoleucine degradation nt06031 Citrate cycle and pyruvate metabolism nt06032 Lipoic acid metabolism nt06033 Glycine, serine and arginine metabolism |
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| Element |
| N01610 | Dihydrolipoamide dehydrogenase |
| N01611 | Glycine cleavage system |
| N01616 | Dihydrolipoamide dehydrogenase |
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| Disease |
| H00072 | Pyruvate dehydrogenase complex deficiency |
| H00172 | Maple syrup urine disease |
| H02000 | Dihydrolipoamide dehydrogenase deficiency |
| H02006 | Alpha-ketoglutarate dehydrogenase complex deficiency |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
1738 (DLD)
00020 Citrate cycle (TCA cycle)
1738 (DLD)
00620 Pyruvate metabolism
1738 (DLD)
00630 Glyoxylate and dicarboxylate metabolism
1738 (DLD)
00640 Propanoate metabolism
1738 (DLD)
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
1738 (DLD)
00280 Valine, leucine and isoleucine degradation
1738 (DLD)
00310 Lysine degradation
1738 (DLD)
00380 Tryptophan metabolism
1738 (DLD)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
1738 (DLD)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
1738 (DLD)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.8 Acting on a sulfur group of donors
1.8.1 With NAD+ or NADP+ as acceptor
1.8.1.4 dihydrolipoyl dehydrogenase
1738 (DLD)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of breast cancer cells
1738 (DLD)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
7:107891107..107921198
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| AA seq |
509 aa
MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
ARVCHAHPTLSEAFREANLAASFGKSINF |
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| NT seq |
1530 nt +upstreamnt +downstreamnt
atgcagagctggagtcgtgtgtactgctccttggccaagagaggccatttcaatcgaata
tctcatggcctacagggactttctgcagtgcctctgagaacttacgcagatcagccgatt
gatgctgatgtaacagttataggttctggtcctggaggatatgttgctgctattaaagct
gcccagttaggcttcaagacagtctgcattgagaaaaatgaaacacttggtggaacatgc
ttgaatgttggttgtattccttctaaggctttattgaacaactctcattattaccatatg
gcccatggaaaagattttgcatctagaggaattgaaatgtccgaagttcgcttgaattta
gacaagatgatggagcagaagagtactgcagtaaaagctttaacaggtggaattgcccac
ttattcaaacagaataaggttgttcatgtcaatggatatggaaagataactggcaaaaat
caagtcactgctacgaaagctgatggcggcactcaggttattgatacaaagaacattctt
atagccacgggttcagaagttactccttttcctggaatcacgatagatgaagatacaata
gtgtcatctacaggtgctttatctttaaaaaaagttccagaaaagatggttgttattggt
gcaggagtaataggtgtagaattgggttcagtttggcaaagacttggtgcagatgtgaca
gcagttgaatttttaggtcatgtaggtggagttggaattgatatggagatatctaaaaac
tttcaacgcatccttcaaaaacaggggtttaaatttaaattgaatacaaaggttactggt
gctaccaagaagtcagatggaaaaattgatgtttctattgaagctgcttctggtggtaaa
gctgaagttatcacttgtgatgtactcttggtttgcattggccgacgaccctttactaag
aatttgggactagaagagctgggaattgaactagatcccagaggtagaattccagtcaat
accagatttcaaactaaaattccaaatatctatgccattggtgatgtagttgctggtcca
atgctggctcacaaagcagaggatgaaggcattatctgtgttgaaggaatggctggtggt
gctgtgcacattgactacaattgtgtgccatcagtgatttacacacaccctgaagttgct
tgggttggcaaatcagaagagcagttgaaagaagagggtattgagtacaaagttgggaaa
ttcccatttgctgctaacagcagagctaagacaaatgctgacacagatggcatggtgaag
atccttgggcagaaatcgacagacagagtactgggagcacatattcttggaccaggtgct
ggagaaatggtaaatgaagctgctcttgctttggaatatggagcatcctgtgaagatata
gctagagtctgtcatgcacatccgaccttatcagaagcttttagagaagcaaatcttgct
gcgtcatttggcaaatcaatcaacttttga |
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