KEGG   Homo sapiens (human): 1850
Entry
1850              CDS       T01001                                 
Symbol
DUSP8, C11orf81, HB5, HVH-5, HVH8
Name
(RefSeq) dual specificity phosphatase 8
  KO
K04459  dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04148  Efferocytosis
Network
nt06526  MAPK signaling
  Element
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1850 (DUSP8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1850 (DUSP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    1850 (DUSP8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     1850 (DUSP8)
    3.1.3.48  protein-tyrosine-phosphatase
     1850 (DUSP8)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    1850 (DUSP8)
SSDB
Motif
Pfam: DSPc Rhodanese Y_phosphatase
Other DBs
NCBI-GeneID: 1850
NCBI-ProteinID: NP_004411
OMIM: 602038
HGNC: 3074
Ensembl: ENSG00000184545
UniProt: Q13202
Structure
Position
11:complement(1554051..1572848)
AA seq 625 aa
MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQ
QGKVTIAELIQPAARSQVEATEPQDVVVYDQSTRDASVLAADSFLSILLSKLDGCFDSVA
ILTGGFATFSSCFPGLCEGKPAALLPMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKD
LMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSC
QVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
KLLAALQGDPGTPSGTPEPPPSPAAGAPLPRLPPPTSESAATGNAAAREGGLSAGGEPPA
PPTPPATSALQQGLRGLHLSSDRLQDTNRLKRSFSLDIKSAYAPSRRPDGPGPPDPGEAP
KLCKLDSPSGAALGLSSPSPDSPDAAPEARPRPRRRPRPPAGSPARSPAHSLGLNFGDAA
RQTPRHGLSALSAPGLPGPGQPAGPGAWAPPLDSPGTPSPDGPWCFSPEGAQGAGGVLFA
PFGRAGAPGPGGGSDLRRREAARAEPRDARTGWPEEPAPETQFKRRSCQMEFEEGMVEGR
ARGEELAALGKQASFSGSVEVIEVS
NT seq 1878 nt   +upstreamnt  +downstreamnt
atggctggggaccggctcccgaggaaggtgatggatgccaagaagctggccagcctgctg
cggggcgggcctggggggccgctggtcatcgacagccgctccttcgtggagtacaacagc
tggcatgtgctcagctccgtcaacatctgctgctccaagctggtgaagcggcggctgcag
cagggcaaggtgaccattgcggagctcatccagccggctgcacgcagccaggtggaggct
acggagccacaggacgtggtggtctatgaccagagcacgcgggacgccagcgtgctggcc
gcagacagcttcctctccatcctgctgagcaagctggacggctgcttcgacagcgtggcc
atcctcactgggggcttcgccaccttctcctcctgcttccccggcctctgcgagggcaag
cctgctgccctgctacccatgagcctctcccagccctgcctgcctgtgcccagcgtgggc
ctgacccgcatcctgcctcacctctacctgggctcgcagaaggacgtcctaaacaaggat
ctgatgacgcaaaatggaataagctacgtcctcaacgccagcaactcctgccccaagcct
gacttcatctgcgagagccgcttcatgcgggtccccatcaacgacaactactgtgaaaaa
ctgctgccctggctggacaagtccatcgagttcatcgataaagccaagctctccagctgc
caagtcatcgtccactgtctggctggcatctcccgctctgccaccatcgccatcgcctac
atcatgaagaccatgggcatgtcctccgacgacgcctacaggttcgtgaaggacaggcgc
ccgtccatctcgcccaacttcaacttcctgggccagctgctggagtacgagcgcagcctg
aagctgctggccgccctgcagggcgacccgggcaccccctcagggacgccggagcctccg
cccagtcctgccgccggggccccgctgccacggctgccaccacctacctcagagagcgct
gccacagggaatgcggctgccagggagggcggcctgagcgcgggcggggagccccccgcg
ccccccacgcccccggcgaccagcgcactgcagcagggcctgcgcggcctgcacctctcc
tcggaccgcctgcaggacactaaccgcctcaagcgctccttctccctggacatcaagtct
gcctacgcccctagcaggcggcccgacggccccgggccccccgaccccggcgaggccccg
aagctctgcaagctggacagcccgtcgggggccgcgctgggcctgtcctcgcccagcccg
gacagcccggacgccgcgcctgaggcgcgcccacggccccgccggcggccccggcccccc
gccggctcccccgcgcgctcccccgcgcacagcctcggcctgaacttcggcgatgcggcc
cggcagactccgcggcacggcctctcggccctgtcggcgcccgggctgcccggccctggc
cagccggccggccccggggcctgggcaccgccgctcgactccccaggcacgccgtcgccc
gacgggccctggtgcttcagccccgagggcgcacagggggcgggcggggtgctgtttgcg
cccttcggccgggcgggcgccccgggaccaggcggcggcagcgacctgcggcggcgggag
gcagcgagggctgagccccgggacgcgcggaccggctggcccgaggagccggccccggag
acgcagttcaagcgccgcagctgccagatggagttcgaggagggcatggtggaggggcgc
gcgcgcggcgaggagctggccgccctgggcaagcaggcgagcttctcgggcagcgtggag
gtcatcgaggtgtcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (18)   
   OC (1)   
Protein sequence (18)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (28)   
   RefSeq(nuc) (16)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (105)   

Download RDF
DBGET integrated database retrieval system