KEGG   Homo sapiens (human): 1901
Entry
1901              CDS       T01001                                 
Symbol
S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Name
(RefSeq) sphingosine-1-phosphate receptor 1
  KO
K04288  sphingosine 1-phosphate receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04148  Efferocytosis
Network
nt06535  Efferocytosis
  Element
N01750  Find-me signal (S1P)
Drug target
Amiselimod (DG02399): D10904 D10905
Cenerimod: D11283
Etrasimod (DG02444): D10930 D10931<US>
Fingolimod (DG00741): D04187<JP/US> D10001 D12549<US>
Mocravimod (DG03288): D12771 D12772
Ozanimod (DG02827): D10967<US> D10968
Ponesimod: D11215<US>
Siponimod (DG03018): D11072<JP/US> D11460
Udifitimod (DG03227): D12376 D12377
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    1901 (S1PR1)
   04071 Sphingolipid signaling pathway
    1901 (S1PR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1901 (S1PR1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1901 (S1PR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1901 (S1PR1)
   04090 CD molecules [BR:hsa04090]
    1901 (S1PR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Sphingolipid
    1901 (S1PR1)
CD molecules [BR:hsa04090]
 Proteins
  1901 (S1PR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 JTB
Other DBs
NCBI-GeneID: 1901
NCBI-ProteinID: NP_001307659
OMIM: 601974
HGNC: 3165
Ensembl: ENSG00000170989
UniProt: P21453
Structure
Position
1:101236899..101242313
AA seq 382 aa
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
NT seq 1149 nt   +upstreamnt  +downstreamnt
atggggcccaccagcgtcccgctggtcaaggcccaccgcagctcggtctctgactacgtc
aactatgatatcatcgtccggcattacaactacacgggaaagctgaatatcagcgcggac
aaggagaacagcattaaactgacctcggtggtgttcattctcatctgctgctttatcatc
ctggagaacatctttgtcttgctgaccatttggaaaaccaagaaattccaccgacccatg
tactattttattggcaatctggccctctcagacctgttggcaggagtagcctacacagct
aacctgctcttgtctggggccaccacctacaagctcactcccgcccagtggtttctgcgg
gaagggagtatgtttgtggccctgtcagcctccgtgttcagtctcctcgccatcgccatt
gagcgctatatcacaatgctgaaaatgaaactccacaacgggagcaataacttccgcctc
ttcctgctaatcagcgcctgctgggtcatctccctcatcctgggtggcctgcctatcatg
ggctggaactgcatcagtgcgctgtccagctgctccaccgtgctgccgctctaccacaag
cactatatcctcttctgcaccacggtcttcactctgcttctgctctccatcgtcattctg
tactgcagaatctactccttggtcaggactcggagccgccgcctgacgttccgcaagaac
atttccaaggccagccgcagctctgagaagtcgctggcgctgctcaagaccgtaattatc
gtcctgagcgtcttcatcgcctgctgggcaccgctcttcatcctgctcctgctggatgtg
ggctgcaaggtgaagacctgtgacatcctcttcagagcggagtacttcctggtgttagct
gtgctcaactccggcaccaaccccatcatttacactctgaccaacaaggagatgcgtcgg
gccttcatccggatcatgtcctgctgcaagtgcccgagcggagactctgctggcaaattc
aagcgacccatcatcgccggcatggaattcagccgcagcaaatcggacaattcctcccac
ccccagaaagacgaaggggacaacccagagaccattatgtcttctggaaacgtcaactct
tcttcctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (17)   
   KEGG DRUG (17)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (40)   
   RefSeq(nuc) (10)   
   GenBank (15)   
   EMBL (15)   
3D Structure (16)   
   PDB (16)   
Protein domain (4)   
   Pfam (4)   
All databases (112)   

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