KEGG   Homo sapiens (human): 1952
Entry
1952              CDS       T01001                                 
Symbol
CELSR2, ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3
Name
(RefSeq) cadherin EGF LAG seven-pass G-type receptor 2
  KO
K04601  cadherin EGF LAG seven-pass G-type receptor 2
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1952 (CELSR2)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1952 (CELSR2)
   04515 Cell adhesion molecules [BR:hsa04515]
    1952 (CELSR2)
Peptidases and inhibitors [BR:hsa01002]
 Mixed peptidases
  Family P2
   1952 (CELSR2)
G protein-coupled receptors [BR:hsa04030]
 Adhesion receptor family
  Cadherin EGF LAG (CELSR)
   1952 (CELSR2)
Cell adhesion molecules [BR:hsa04515]
 Cadherins
  Major cadherins
   1952 (CELSR2)
SSDB
Motif
Pfam: Cadherin GAIN 7tm_2 Laminin_G_2 Laminin_G_1 EGF GPS Cadherin_3 Laminin_EGF RET_CLD1 Cadherin_4 Cadherin_pro hEGF Dicty_CAR Frizzled
Other DBs
NCBI-GeneID: 1952
NCBI-ProteinID: NP_001399
OMIM: 604265
HGNC: 3231
Ensembl: ENSG00000143126
UniProt: Q9HCU4
Position
1:109249539..109275751
AA seq 2923 aa
MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPS
SASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIG
GHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQ
FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGA
VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE
NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV
ESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLR
VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG
RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL
EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTV
LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITS
QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVN
VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS
YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT
DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP
ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI
VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNP
PVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTG
ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPER
FLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFL
PSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSS
VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTG
EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITF
RGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVS
PFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLG
NYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMAD
FIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFL
GSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGT
GLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLS
NITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSN
PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPN
YLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPT
CLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAI
EAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERL
QRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQ
DVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPF
TIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAG
PGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINT
PVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCE
VVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTL
LRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLE
ALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLI
WSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLAL
LSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTL
TSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLG
DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG
WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSR
EGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPP
RPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH
NT seq 8772 nt   +upstreamnt  +downstreamnt
atgcggagcccggccaccggcgtccccctcccaacgccgccgccgccgctgctgctgctg
ttgctgctgctgctgccgccgccactattgggagaccaagtggggccctgtcgttccttg
gggtccaggggacgaggctcttcgggggcctgcgcccccatgggctggctctgtccatcc
tcagcgtcgaacctctggctctacaccagccgctgcagggatgcgggcactgagctgact
ggccacctggtaccccaccacgatggcctgagggtttggtgtccagaatccgaggcccat
attcccctaccaccagctcctgaaggctgcccctggagctgtcgcctcctgggcattgga
ggccacctttccccacagggcaagctcacactgcccgaggagcacccgtgcttaaaggct
ccacggctcagatgccagtcctgcaagctggcacaggcccccgggctcagggcaggggaa
aggtcaccagaagagtccctgggtgggcgtcggaaaaggaatgtaaatacagccccccag
ttccagccccccagctaccaggccacagtgccggagaaccagccagcaggcacccctgtt
gcatccctgagggccatcgacccggacgagggtgaggcaggtcgactggagtacaccatg
gatgccctctttgatagccgctccaaccagttcttctccctggacccagtcactggtgca
gtaaccacagccgaggagctggatcgtgagaccaagagcacccacgtcttcagggtcacg
gcgcaggaccacggcatgccccgacgaagtgccctggctacactcaccatcttggttact
gacaccaatgaccatgaccctgtgttcgagcagcaggagtacaaggagagcctcagggag
aacctggaggttggctatgaggtgctcactgtcagggccacggatggtgatgcccctccc
aatgccaatattctgtaccgcctgctggaggggtctgggggcagcccctctgaagtcttt
gagatcgaccctcgctctggggtgatccgaacccgtggccctgtggatcgggaagaggtg
gaatcctaccagctgacggtagaggcaagtgaccagggtcgggacccgggtcctcggagt
accacagccgctgttttcctttctgtggaggatgacaatgataatgccccccagtttagt
gagaagcgctatgtggtccaggtgagggaggatgtgactccaggggccccagtactccga
gtcacagcctcggatcgagacaaggggagcaatgccgtggtgcactatagcatcatgagt
ggcaatgctcggggacagttttatctggatgcccagactggagctctggatgtggtgagc
cctcttgactatgagacgaccaaggagtacaccctacgggtgcgagcacaggatggtggc
cgtcccccactctctaatgtctctggcttggtgacagtacaggtcctggatatcaacgac
aatgcccccatcttcgtcagcacccctttccaggctactgtcctggagagtgtcccctta
ggctacctggttctccatgtccaggctatcgacgctgatgctggtgacaatgcccgcctg
gaataccgccttgctggggtgggacatgacttccccttcaccatcaacaatggcacaggc
tggatctctgtggctgctgaactggaccgggaggaagttgatttctacagctttggggta
gaagctcgagaccatggcactccagcactcactgcctcggccagtgtcagcgtgactgtc
ctggatgtcaacgacaacaatccaacctttacccaaccagagtacacagtgcggctcaat
gaggatgcagctgtgggcaccagcgtggtgacggtgtcagctgtggaccgtgatgctcat
agtgtcatcacctaccagatcaccagtggcaatactcgaaaccgcttctccatcaccagc
caaagtggtggtgggctggtatcccttgccctgccactggactacaaacttgagcggcag
tatgtgttggctgttaccgcctccgatggcactcggcaggacacggcacagattgtggtg
aatgtcaccgacgccaacacccatcgtcctgtctttcagagctcccactatacagtgaat
gttaatgaggaccggccggcaggcaccacggtggtgctgatcagcgccacggatgaggac
acaggtgagaatgcccgcatcacctacttcatggaggacagcatcccccagttccgcatc
gatgcagacacgggggctgtcaccacccaggctgagctggactatgaagaccaagtgtct
tacaccctggccattactgctcgggacaatggcattccccagaagtccgacaccacctac
ctggagatcctggtgaacgacgtgaatgacaatgcccctcagttcctgcgagactcctac
cagggcagtgtctatgaggatgtgccacccttcactagcgtcctgcagatctcagccact
gatcgtgattctggacttaatggcagggtcttctacaccttccaaggaggcgacgatgga
gacggtgactttattgttgagtccacgtcaggcatcgtgcgaacgctacggaggctggat
cgagagaacgtggcccagtatgtcttgcgggcatatgcagtggacaaggggatgccccca
gcccgcacacctatggaagtgacagtcactgtgttggatgtgaatgacaatccccctgtc
tttgagcaggatgagtttgatgtgtttgtggaagagaacagccccattgggctagccgtg
gcccgggtcacagccactgaccccgatgaaggcaccaatgcccagattatgtaccagatt
gtggagggcaacatccctgaggtctttcagctggacatcttctccggggagctgacagcc
ctggtagacttagactacgaggaccggcctgagtacgtcctggtcatccaggccacgtca
gctcctctggtgagccgggctacagtccacgtccgcctccttgaccgcaatgacaaccca
ccagtgctgggcaactttgagatccttttcaacaactatgtcaccaatcgctcaagcagc
ttccctgggggtgccattggccgagtacctgcccatgaccctgatatctcagatagtctg
acttacagctttgagcggggaaatgaactcagcctggtcctgctcaatgcctccacgggt
gagctgaagctaagccgcgcactggacaacaaccggcctctggaggccatcatgagcgtg
ctggtgtcagacggcgtacacagcgtgaccgcccagtgcgcgctgcgtgtgaccatcatc
accgatgagatgctcacccacagcatcacgctgcgcctggaggacatgtcacccgagcgc
ttcctgtcaccactgctaggcctcttcatccaggcggtggccgccacgctggccacgcca
ccggaccacgtggtggtcttcaacgtacagcgggacaccgacgcccccgggggccacatc
ctcaacgtgagcctgtcggtgggccagccgccagggcccgggggcgggccgcccttcctg
ccctctgaggacctgcaggagcgcctatacctcaaccgcagcctgctgacggccatctcg
gcacagcgcgtgctgcccttcgacgacaacatctgcctgcgggagccctgcgagaactac
atgcgctgcgtgtcggtgctgcgcttcgactcctccgcgcccttcatcgcctcctcctcc
gtgctcttccggcccatccaccccgtcggagggctgcgctgccgctgcccgcccggcttc
acgggtgactactgcgagaccgaggtggacctctgctactcgcggccctgtggcccccac
gggcgctgccgcagccgcgagggcggctacacctgcctctgtcgtgatggctacacgggt
gagcactgtgaggtgagtgctcgctcaggccgttgcaccccgggtgtctgcaagaatggg
ggcacctgtgtcaacctgctggtgggcggtttcaagtgcgattgcccatctggagacttc
gagaagccctactgccaggtgaccacgcgcagcttccccgcccactccttcatcaccttt
cgcggcctgcgccagcgtttccacttcaccctggccctctcgtttgccacaaaggagcgc
gacgggttgctgttgtacaatgggcgtttcaatgagaagcatgactttgtggccctcgag
gtgatccaggagcaggtccagctcaccttctctgcaggggagtcaaccaccacggtgtcc
ccattcgtgcccggaggagtcagtgatggccagtggcatacggtgcagctgaaatactac
aataagccactgttgggtcagacagggctcccacagggcccatcagagcagaaggtggct
gtggtgaccgtggatggctgtgacacaggagtggccttgcgcttcggatctgtcctgggc
aactactcctgtgctgcccagggcacccagggtggcagcaagaagtctctggatctgacg
gggcccctgctactaggcggggtgcctgacctgcccgagagcttcccagtccgaatgcgg
cagttcgtgggctgcatgcggaacctgcaggtggacagccggcacatagacatggctgac
ttcattgccaacaatggcaccgtgcctggctgccctgccaagaagaacgtgtgtgacagc
aacacttgccacaatgggggcacttgcgtgaaccagtgggacgcgttcagctgcgagtgc
cccctgggctttgggggcaagagctgcgcccaggaaatggccaatccacagcacttcctg
ggcagcagcctggtggcctggcatggcctctcgctgcccatctcccaaccctggtacctc
agcctcatgttccgcacgcgccaggccgacggtgtcctgctgcaggccatcaccaggggg
cgcagcaccatcaccctacagctacgagagggccacgtgatgctgagcgtggagggcaca
gggcttcaggcctcctctctccgtctggagccaggccgggccaatgacggtgactggcac
catgcacagctggcactgggagccagcggggggcccggccatgccattctgtccttcgat
tatgggcagcagagagcagagggcaacctgggcccccggctgcatggtctgcacctgagc
aacataacagtgggcggaatacctgggccagccggcggtgtggcccgtggctttcggggc
tgtttgcagggtgtgcgggtgagcgatacgccggagggggttaacagcctggatcccagc
catggggagagcatcaacgtggagcaaggctgtagcctgcctgacccttgtgactcaaac
ccgtgtcctgctaacagctattgcagcaacgactgggacagctattcctgcagctgtgat
ccaggttactatggtgacaactgtactaatgtgtgtgacctgaacccgtgtgagcaccag
tctgtgtgtacccgcaagcccagtgccccccatggctatacctgcgagtgtcccccaaat
taccttgggccatactgtgagaccaggattgaccagccttgtccccgtggctggtgggga
catcccacatgtggcccatgcaactgtgatgtcagcaaaggctttgacccagactgcaac
aagacaagcggcgagtgccactgcaaggagaaccactaccggcccccaggcagccccacc
tgcctcttgtgtgactgctaccccacaggctccttgtccagagtctgtgaccctgaggat
ggccagtgtccatgcaagccaggtgtcatcgggcgtcagtgtgaccgctgtgacaaccct
tttgctgaggtcaccaccaatggctgtgaagtgaattatgacagctgcccacgagcgatt
gaggctgggatctggtggccccgtacccgcttcgggctgcctgctgctgctccctgtccc
aaaggctcctttgggactgctgtgcgccactgtgatgagcacagggggtggctcccccca
aacctcttcaactgcacgtccatcaccttctcagaactgaagggcttcgctgagcggcta
cagcggaatgagtcaggcctagactcagggcgctcccagcagctagccctgctcctgcgc
aacgccacgcagcacacagctggctacttcggcagcgacgtcaaggtggcctaccagctg
gccacgcggctgctggcccacgagagcacccagcggggctttgggctgtctgccacacag
gacgtgcacttcactgagaatctgctgcgggtgggcagcgccctcctggacacagccaac
aagcggcactgggagctgatccagcagacagagggtggcaccgcctggctgctccagcac
tatgaggcctacgccagtgccctggcccagaacatgcggcacacctacctaagccccttc
accatcgtcacgcccaacattgtcatctccgtagtgcgcttggacaaagggaactttgct
ggggccaagctgccccgctacgaggccctgcgtggggagcagcccccggaccttgagaca
acagtcattctgcctgagtctgtcttcagagagacgccccccgtggtcaggcccgcaggc
cccggagaggcccaggagccagaggagctggcacggcgacagcgacggcacccggagctg
agccagggtgaggctgtggccagcgtcatcatctaccgcaccctggccgggctactgcct
cataactatgaccctgacaagcgcagcttgagagtccccaaacgcccgatcatcaacaca
cccgtggtgagcatcagcgtccatgatgatgaggagcttctgccccgggccctggacaaa
cccgtcacggtgcagttccgcctgctggagacagaggagcggaccaagcccatctgtgtc
ttctggaaccattcaatcctggtcagtggcacaggtggctggtcggccagaggctgtgaa
gtcgtcttccgcaatgagagccacgtcagctgccagtgcaaccacatgacgagcttcgct
gtgctcatggacgtttctcggcgggagaatggggagatcctgccactgaagacactgaca
tacgtggctctaggtgtcaccttggctgcccttctgctcaccttcttcttcctcactctc
ttgcgtatcctgcgctccaaccaacacggcatccgacgtaacctgacagctgccctgggc
ctggctcagctggtcttcctcctgggaatcaaccaggctgacctcccttttgcctgcaca
gtcattgccatcctgctgcacttcctgtacctctgcaccttttcctgggctctgctggag
gccttgcacctgtaccgggcactcactgaggtgcgcgatgtcaacaccggccccatgcgc
ttctactacatgctgggctggggcgtgcctgccttcatcacagggctagccgtgggcctg
gaccccgagggctacgggaaccctgacttctgctggctctccatctatgacacgctcatc
tggagttttgctggcccggtggcctttgccgtctcgatgagtgtcttcctgtacatcctg
gcggcccgggcctcctgtgctgcccagcggcagggctttgagaagaaaggtcctgtctcg
ggcctgcagccctccttcgccgtcctcctgctgctgagcgccacgtggctgctggcactg
ctctctgtcaacagcgacaccctcctcttccactacctctttgctacctgcaattgcatc
cagggccccttcatcttcctctcctatgtggtgcttagcaaggaggtccggaaagcactc
aagcttgcctgcagccgcaagcccagccctgaccctgctctgaccaccaagtccaccctg
acctcgtcctacaactgccccagcccctacgcagatgggcggctgtaccagccctacgga
gactcggccggctctctgcacagcaccagtcgctcgggcaagagtcagcccagctacatc
cccttcttgctgagggaggagtccgcactgaaccctggccaagggccccctggcctgggg
gatccaggcagcctgttcctggaaggtcaagaccagcagcatgatcctgacacggactcc
gacagtgacctgtccttagaagacgaccagagtggctcctatgcctctacccactcatca
gacagtgaggaggaagaagaggaggaggaagaggaggccgccttccctggagagcagggc
tgggatagcctgctggggcctggagcagagagactgcccctgcacagtactcccaaggat
gggggcccagggcctggcaaggccccctggccaggagactttgggaccacagcaaaagag
agtagtggcaacggggcccctgaggagcggctgcgggagaatggagatgccctgtctcga
gaggggtccctaggcccccttccaggctcttctgcccagcctcacaaaggcatccttaag
aagaagtgtctgcccaccatcagcgagaagagcagcctcctgcggctccccctggagcaa
tgcacagggtcttcccggggctcctccgctagtgagggcagccggggaggcccccctccc
cgcccaccgccccggcagagcctccaggagcagctgaacggggtcatgcccatcgccatg
agcatcaaggcaggcacggtggatgaggactcgtcaggctccgaatttctcttctttaac
ttcctgcattaa

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Ontology (4)   
   KEGG BRITE (4)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (29)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
Protein domain (15)   
   Pfam (15)   
All databases (72)   

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