KEGG   Homo sapiens (human): 2
Entry
2                 CDS       T01001                                 
Symbol
A2M, A2MD, CPAMD5, FWP007, S863-7
Name
(RefSeq) alpha-2-macroglobulin
  KO
K03910  alpha-2-macroglobulin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2 (A2M)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2 (A2M)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2 (A2M)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2 (A2M)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I39: alpha2M family
   2 (A2M)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    2 (A2M)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   2 (A2M)
SSDB
Motif
Pfam: TED_complement A2M_BRD A2M MG4 A2M_recep MG3 MG2 SVA Big_1 MG1 MP
Other DBs
NCBI-GeneID: 2
NCBI-ProteinID: NP_000005
OMIM: 103950
HGNC: 7
Ensembl: ENSG00000175899
UniProt: P01023
Structure
Position
12:complement(9067708..9116229)
AA seq 1474 aa
MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTV
SASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTV
MVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQS
FQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIIT
ILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCF
YQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFR
QGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLT
VRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHY
ILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARL
LIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAV
DQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSS
TNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARL
VHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGI
SSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVE
KEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVI
KPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQ
NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKH
YDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCF
RSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDH
GSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQ
APSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHA
LSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEG
CVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAI
VDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVR
DLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA
NT seq 4425 nt   +upstreamnt  +downstreamnt
atggggaagaacaaactccttcatccaagtctggttcttctcctcttggtcctcctgccc
acagacgcctcagtctctggaaaaccgcagtatatggttctggtcccctccctgctccac
actgagaccactgagaagggctgtgtccttctgagctacctgaatgagacagtgactgta
agtgcttccttggagtctgtcaggggaaacaggagcctcttcactgacctggaggcggag
aatgacgtactccactgtgtcgccttcgctgtcccaaagtcttcatccaatgaggaggta
atgttcctcactgtccaagtgaaaggaccaacccaagaatttaagaagcggaccacagtg
atggttaagaacgaggacagtctggtctttgtccagacagacaaatcaatctacaaacca
gggcagacagtgaaatttcgtgttgtctccatggatgaaaactttcaccccctgaatgag
ttgattccactagtatacattcaggatcccaaaggaaatcgcatcgcacaatggcagagt
ttccagttagagggtggcctcaagcaattttcttttcccctctcatcagagcccttccag
ggctcctacaaggtggtggtacagaagaaatcaggtggaaggacagagcaccctttcacc
gtggaggaatttgttcttcccaagtttgaagtacaagtaacagtgccaaagataatcacc
atcttggaagaagagatgaatgtatcagtgtgtggcctatacacatatgggaagcctgtc
cctggacatgtgactgtgagcatttgcagaaagtatagtgacgcttccgactgccacggt
gaagattcacaggctttctgtgagaaattcagtggacagctaaacagccatggctgcttc
tatcagcaagtaaaaaccaaggtcttccagctgaagaggaaggagtatgaaatgaaactt
cacactgaggcccagatccaagaagaaggaacagtggtggaattgactggaaggcagtcc
agtgaaatcacaagaaccataaccaaactctcatttgtgaaagtggactcacactttcga
cagggaattcccttctttgggcaggtgcgcctagtagatgggaaaggcgtccctatacca
aataaagtcatattcatcagaggaaatgaagcaaactattactccaatgctaccacggat
gagcatggccttgtacagttctctatcaacaccaccaatgttatgggtacctctcttact
gttagggtcaattacaaggatcgtagtccctgttacggctaccagtgggtgtcagaagaa
cacgaagaggcacatcacactgcttatcttgtgttctccccaagcaagagctttgtccac
cttgagcccatgtctcatgaactaccctgtggccatactcagacagtccaggcacattat
attctgaatggaggcaccctgctggggctgaagaagctctccttctattatctgataatg
gcaaagggaggcattgtccgaactgggactcatggactgcttgtgaagcaggaagacatg
aagggccatttttccatctcaatccctgtgaagtcagacattgctcctgtcgctcggttg
ctcatctatgctgttttacctaccggggacgtgattggggattctgcaaaatatgatgtt
gaaaattgtctggccaacaaggtggatttgagcttcagcccatcacaaagtctcccagcc
tcacacgcccacctgcgagtcacagcggctcctcagtccgtctgcgccctccgtgctgtg
gaccaaagcgtgctgctcatgaagcctgatgctgagctctcggcgtcctcggtttacaac
ctgctaccagaaaaggacctcactggcttccctgggcctttgaatgaccaggacaatgaa
gactgcatcaatcgtcataatgtctatattaatggaatcacatatactccagtatcaagt
acaaatgaaaaggatatgtacagcttcctagaggacatgggcttaaaggcattcaccaac
tcaaagattcgtaaacccaaaatgtgtccacagcttcaacagtatgaaatgcatggacct
gaaggtctacgtgtaggtttttatgagtcagatgtaatgggaagaggccatgcacgcctg
gtgcatgttgaagagcctcacacggagaccgtacgaaagtacttccctgagacatggatc
tgggatttggtggtggtaaactcagcaggtgtggctgaggtaggagtaacagtccctgac
accatcaccgagtggaaggcaggggccttctgcctgtctgaagatgctggacttggtatc
tcttccactgcctctctccgagccttccagcccttctttgtggagctcacaatgccttac
tctgtgattcgtggagaggccttcacactcaaggccacggtcctaaactaccttcccaaa
tgcatccgggtcagtgtgcagctggaagcctctcccgccttcctagctgtcccagtggag
aaggaacaagcgcctcactgcatctgtgcaaacgggcggcaaactgtgtcctgggcagta
accccaaagtcattaggaaatgtgaatttcactgtgagcgcagaggcactagagtctcaa
gagctgtgtgggactgaggtgccttcagttcctgaacacggaaggaaagacacagtcatc
aagcctctgttggttgaacctgaaggactagagaaggaaacaacattcaactccctactt
tgtccatcaggtggtgaggtttctgaagaattatccctgaaactgccaccaaatgtggta
gaagaatctgcccgagcttctgtctcagttttgggagacatattaggctctgccatgcaa
aacacacaaaatcttctccagatgccctatggctgtggagagcagaatatggtcctcttt
gctcctaacatctatgtactggattatctaaatgaaacacagcagcttactccagagatc
aagtccaaggccattggctatctcaacactggttaccagagacagttgaactacaaacac
tatgatggctcctacagcacctttggggagcgatatggcaggaaccagggcaacacctgg
ctcacagcctttgttctgaagacttttgcccaagctcgagcctacatcttcatcgatgaa
gcacacattacccaagccctcatatggctctcccagaggcagaaggacaatggctgtttc
aggagctctgggtcactgctcaacaatgccataaagggaggagtagaagatgaagtgacc
ctctccgcctatatcaccatcgcccttctggagattcctctcacagtcactcaccctgtt
gtccgcaatgccctgttttgcctggagtcagcctggaagacagcacaagaaggggaccat
ggcagccatgtatataccaaagcactgctggcctatgcttttgccctggcaggtaaccag
gacaagaggaaggaagtactcaagtcacttaatgaggaagctgtgaagaaagacaactct
gtccattgggagcgccctcagaaacccaaggcaccagtggggcatttttacgaaccccag
gctccctctgctgaggtggagatgacatcctatgtgctcctcgcttatctcacggcccag
ccagccccaacctcggaggacctgacctctgcaaccaacatcgtgaagtggatcacgaag
cagcagaatgcccagggcggtttctcctccacccaggacacagtggtggctctccatgct
ctgtccaaatatggagcagccacatttaccaggactgggaaggctgcacaggtgactatc
cagtcttcagggacattttccagcaaattccaagtggacaacaacaaccgcctgttactg
cagcaggtctcattgccagagctgcctggggaatacagcatgaaagtgacaggagaagga
tgtgtctacctccagacatccttgaaatacaatattctcccagaaaaggaagagttcccc
tttgctttaggagtgcagactctgcctcaaacttgtgatgaacccaaagcccacaccagc
ttccaaatctccctaagtgtcagttacacagggagccgctctgcctccaacatggcgatc
gttgatgtgaagatggtctctggcttcattcccctgaagccaacagtgaaaatgcttgaa
agatctaaccatgtgagccggacagaagtcagcagcaaccatgtcttgatttaccttgat
aaggtgtcaaatcagacactgagcttgttcttcacggttctgcaagatgtcccagtaaga
gatctgaaaccagccatagtgaaagtctatgattactacgagacggatgagtttgcaatt
gctgagtacaatgctccttgcagcaaagatcttggaaatgcttga

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