KEGG   Homo sapiens (human): 201633
Entry
201633            CDS       T01001                                 
Symbol
TIGIT, VSIG9, VSTM3, WUCAM
Name
(RefSeq) T cell immunoreceptor with Ig and ITIM domains
  KO
K16350  T-cell immunoreceptor with Ig and ITIM domains
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
Drug target
Belrestotug: D12348
Domvanalimab: D12367
Etigilimab: D11593
Ociperlimab: D12283
Rilvegostomig: D12764
Tiragolumab: D11482
Vibostolimab: D11795
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    201633 (TIGIT)
SSDB
Motif
Pfam: V-set ig Ig_3 Ig_2 I-set
Other DBs
NCBI-GeneID: 201633
NCBI-ProteinID: NP_776160
OMIM: 612859
HGNC: 26838
Ensembl: ENSG00000181847
UniProt: Q495A1
Structure
Position
3:114294028..114310288
AA seq 244 aa
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWE
QQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTG
RIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLR
RKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFF
TETG
NT seq 735 nt   +upstreamnt  +downstreamnt
atgcgctggtgtctcctcctgatctgggcccaggggctgaggcaggctcccctcgcctca
ggaatgatgacaggcacaatagaaacaacggggaacatttctgcagagaaaggtggctct
atcatcttacaatgtcacctctcctccaccacggcacaagtgacccaggtcaactgggag
cagcaggaccagcttctggccatttgtaatgctgacttggggtggcacatctccccatcc
ttcaaggatcgagtggccccaggtcccggcctgggcctcaccctccagtcgctgaccgtg
aacgatacaggggagtacttctgcatctatcacacctaccctgatgggacgtacactggg
agaatcttcctggaggtcctagaaagctcagtggctgagcacggtgccaggttccagatt
ccattgcttggagccatggccgcgacgctggtggtcatctgcacagcagtcatcgtggtg
gtcgcgttgactagaaagaagaaagccctcagaatccattctgtggaaggtgacctcagg
agaaaatcagctggacaggaggaatggagccccagtgctccctcacccccaggaagctgt
gtccaggcagaagctgcacctgctgggctctgtggagagcagcggggagaggactgtgcc
gagctgcatgactacttcaatgtcctgagttacagaagcctgggtaactgcagcttcttc
acagagactggttag

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (7)   
   KEGG DRUG (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (22)   
   RefSeq(nuc) (6)   
   GenBank (8)   
   EMBL (8)   
3D Structure (7)   
   PDB (7)   
Protein domain (5)   
   Pfam (5)   
All databases (61)   

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