KEGG   Homo sapiens (human): 2026
Entry
2026              CDS       T01001                                 
Symbol
ENO2, HEL-S-279, NSE
Name
(RefSeq) enolase 2
  KO
K01689  enolase 1/2/3 [EC:4.2.1.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
hsa03018  RNA degradation
hsa04066  HIF-1 signaling pathway
hsa04820  Cytoskeleton in muscle cells
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00002  Glycolysis, core module involving three-carbon compounds
hsa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P
Network
nt06017  Glycogen metabolism
  Element
N00731  Glycolysis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    2026 (ENO2)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    2026 (ENO2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    2026 (ENO2)
 09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    2026 (ENO2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    2026 (ENO2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2026 (ENO2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.11  phosphopyruvate hydratase
     2026 (ENO2)
Messenger RNA biogenesis [BR:hsa03019]
 Prokaryotic type
  Bacterial mRNA degradation factors
   RNA degradosome components
    Other RNA degradosome components
     2026 (ENO2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   2026 (ENO2)
SSDB
Motif
Pfam: Enolase_C Enolase_N MR_MLE_C MAAL_C
Other DBs
NCBI-GeneID: 2026
NCBI-ProteinID: NP_001966
OMIM: 131360
HGNC: 3353
Ensembl: ENSG00000111674
UniProt: P09104 Q6FHV6
Structure
Position
12:6914580..6923697
AA seq 434 aa
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGK
GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCK
AGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRD
AMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKI
VIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLA
QENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE
ARFAGHNFRNPSVL
NT seq 1305 nt   +upstreamnt  +downstreamnt
atgtccatagagaagatctgggcccgggagatcctggactcccgcgggaaccccacagtg
gaggtggatctctatactgccaaaggtcttttccgggctgcagtgcccagtggagcctct
acgggcatctatgaggccctggagctgagggatggagacaaacagcgttacttaggcaaa
ggtgtcctgaaggcagtggaccacatcaactccaccatcgcgccagccctcatcagctca
ggtctctctgtggtggagcaagagaaactggacaacctgatgctggagttggatgggact
gagaacaaatccaagtttggggccaatgccatcctgggtgtgtctctggccgtgtgtaag
gcaggggcagctgagcgggaactgcccctgtatcgccacattgctcagctggccgggaac
tcagacctcatcctgcctgtgccggccttcaacgtgatcaatggtggctctcatgctggc
aacaagctggccatgcaggagttcatgatcctcccagtgggagctgagagctttcgggat
gccatgcgactaggtgcagaggtctaccatacactcaagggagtcatcaaggacaaatac
ggcaaggatgccaccaatgtgggggatgaaggtggctttgcccccaatatcctggagaac
agtgaagccttggagctggtgaaggaagccatcgacaaggctggctacacggaaaagatc
gttattggcatggatgttgctgcctcagagttttatcgtgatggcaaatatgacttggac
ttcaagtctcccactgatccttcccgatacatcactggggaccagctgggggcactctac
caggactttgtcagggactatcctgtggtctccattgaggacccatttgaccaggatgat
tgggctgcctggtccaagttcacagccaatgtagggatccagattgtgggtgatgacctg
acagtgaccaacccaaaacgtattgagcgggcagtggaagaaaaggcctgcaactgtctg
ctgctcaaggtcaaccagatcggctcggtcactgaagccatccaagcgtgcaagctggcc
caggagaatggctggggggtcatggtgagtcatcgctcaggagagactgaggacacattc
attgctgacctggtggtggggctgtgcacaggccagatcaagactggtgccccgtgccgt
tctgaacgtctggctaaatacaaccagctcatgagaattgaggaagagctgggggatgaa
gctcgctttgccggacataacttccgtaatcccagtgtgctgtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (11)   
   KEGG PATHWAY (7)   
   KEGG MODULE (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (16)   
   PDB (16)   
Protein domain (4)   
   Pfam (4)   
All databases (98)   

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