KEGG   Homo sapiens (human): 2052
Entry
2052              CDS       T01001                                 
Symbol
EPHX1, EPHX, EPOX, HYL1, MEH
Name
(RefSeq) epoxide hydrolase 1
  KO
K01253  microsomal epoxide hydrolase [EC:3.3.2.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa04976  Bile secretion
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06250  DNA adduct formation (cancer)
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01374  BaP to DNA adducts
N01375  DMBA to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2052 (EPHX1)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    2052 (EPHX1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    2052 (EPHX1)
   05207 Chemical carcinogenesis - receptor activation
    2052 (EPHX1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2052 (EPHX1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2052 (EPHX1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.9  microsomal epoxide hydrolase
     2052 (EPHX1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S33
   2052 (EPHX1)
SSDB
Motif
Pfam: Abhydrolase_1 EHN Abhydrolase_6
Other DBs
NCBI-GeneID: 2052
NCBI-ProteinID: NP_000111
OMIM: 132810
HGNC: 3401
Ensembl: ENSG00000143819
UniProt: P07099 R4SBI6
Position
1:225810124..225845563
AA seq 455 aa
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI
HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI
EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV
ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP
SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML
YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL
ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
NT seq 1368 nt   +upstreamnt  +downstreamnt
atgtggctagaaatcctcctcacttcagtgctgggctttgccatctactggttcatctcc
cgggacaaagaggaaactttgccacttgaagatgggtggtgggggccaggcacgaggtcc
gcagccagggaggacgacagcatccgccctttcaaggtggaaacgtcagatgaggagatc
cacgacttacaccagaggatcgataagttccgtttcaccccacctttggaggacagctgc
ttccactatggcttcaactccaactacctgaagaaagtcatctcctactggcggaatgaa
tttgactggaagaagcaggtggagattctcaacagataccctcacttcaagactaagatt
gaagggctggacatccacttcatccacgtgaagcccccccagctgcccgcaggccatacc
ccgaagcccttgctgatggtgcacggctggcccggctctttctacgagttttataagatc
atcccactcctgactgaccccaagaaccatggcctgagcgatgagcacgtttttgaagtc
atctgcccttccatccctggctatggcttctcagaggcatcctccaagaaggggttcaac
tcggtggccaccgccaggatcttttacaagctgatgctgcggctgggcttccaggaattc
tacattcaaggaggggactgggggtccctgatctgcactaatatggcccagctggtgccc
agccacgtgaaaggcctgcacttgaacatggctttggttttaagcaacttctctaccctg
accctcctcctgggacagcgtttcgggaggtttcttggcctcactgagagggatgtggag
ctgctgtaccccgtcaaggagaaggtattctacagcctgatgagggagagcggctacatg
cacatccagtgcaccaagcctgacaccgtaggctctgctctgaatgactctcctgtgggt
ctggctgcctatattctagagaagttttccacctggaccaatacggaattccgatacctg
gaggatggaggcctggaaaggaagttctccctggacgacctgctgaccaacgtcatgctc
tactggacaacaggcaccatcatctcctcccagcgcttctacaaggagaacctgggacag
ggctggatgacccagaagcatgagcggatgaaggtctatgtgcccactggcttctctgcc
ttcccttttgagctattgcacacgcctgaaaagtgggtgaggttcaagtacccaaagctc
atctcctattcctacatggttcgtgggggccactttgcggcctttgaggagccggagctg
ctcgcccaggacatccgcaagttcctgtcggtgctggagcggcaatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (5)   
   KEGG NETWORK (5)   
Disease (1)   
   OMIM (1)   
Chemical substance (18)   
   KEGG COMPOUND (18)   
Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (50)   
   RefSeq(nuc) (14)   
   GenBank (18)   
   EMBL (18)   
Protein domain (3)   
   Pfam (3)   
All databases (127)   

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