KEGG   Homo sapiens (human): 22999
Entry
22999             CDS       T01001                                 
Symbol
RIMS1, CORD7, RAB3IP2, RIM, RIM1
Name
(RefSeq) regulating synaptic membrane exocytosis 1
  KO
K15291  regulating synaptic membrane exocytosis protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04723  Retrograde endocannabinoid signaling
Disease
H00481  Cone-rod dystrophy and cone dystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    22999 (RIMS1)
   04721 Synaptic vesicle cycle
    22999 (RIMS1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    22999 (RIMS1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    22999 (RIMS1)
  Small GTPases and associated proteins
   Rab associated proteins
    22999 (RIMS1)
SSDB
Motif
Pfam: C2 PDZ FYVE_2 PDZ_6 Nudix_N_2
Other DBs
NCBI-GeneID: 22999
NCBI-ProteinID: NP_055804
OMIM: 606629
HGNC: 17282
Ensembl: ENSG00000079841
UniProt: Q86UR5 Q3ZCW0 B7Z7W2
Structure
Position
6:71886550..72403145
AA seq 1692 aa
MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRD
MAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH
KTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFF
GSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPD
RSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQP
VEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPN
LARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS
PPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSS
AVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVST
PEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRV
ILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWN
GKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKME
RPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNP
YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQE
EESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQR
SQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGN
DQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSEL
LMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQ
DISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSL
DRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPR
ATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPAD
TSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYS
KYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFT
PKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA
IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSE
GNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRA
RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQ
VIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSS
LESSTGPPCIRS
NT seq 5079 nt   +upstreamnt  +downstreamnt
atgtcctcggccgtggggccccgcggtcctcgcccacccacggtgcctccccccatgcaa
gagctgcccgacctgagccacctgaccgaagaggagaggaacattatcatggcagtgatg
gaccggcagaaggaagaggaggaaaaagaagaagccatgctcaagtgtgttgtcagggac
atggcgaagcctgctgcctgcaaaacaccaagaaatgctgaaaaccagccccaccaacct
tcaccgagattgcatcaacagtttgaaagctataaggaacaagtgagaaaaataggggaa
gaagcgcggcgttaccagggcgagcacaaagacgatgctccgacttgtggaatctgtcat
aaaacaaagtttgctgatgggtgcggtcatctctgctcctattgtcgcactaagttctgt
gcgcgctgcggaggccgcgtgtctctacggtcaaacaacgaggacaaagtggttatgtgg
gtatgcaatttatgtcgaaagcaacaagaaatcttaaccaaatctggggcatggttcttt
ggaagtggccctcagcagacaagtcaggatggaaccctgagtgatacagctacaggtgct
ggctctgaggtaccaagagaaaagaaagcacgactccaagagcgatcgcggtctcagaca
cccctaagcacagcagctgcctcctcccaggatgctgctcctcccagcgcaccaccagac
aggagcaaaggggctgagccctcgcagcaagccttggggcctgaacagaagcaggcttca
tccaggtctagaagtgaacctcctagagagagaaagaagaccccagggctttccgagcag
aatggcaaaggagccctgaagagcgagcggaaacgcgtgccaaagacctcagcgcagccc
gtggagggggccgtcgaagaacgggagcgcaaagaaaggcgggaaagccgaaggcttgag
aaagggcgatcacaggattacccagacacgccggaaaaacgggatgagggcaaagcggcg
gatgaggaaaagcaaagaaaagaggaggattatcagaccaggtaccgcagcgacccgaac
ctagctcggtacccggtgaaaccgccgcctgaggagcagcagatgcgcatgcacgcccgg
gtgtcccgcgccaggcacgagcggcgccacagcgacgtggcgctcccgcgcaccgaggcg
ggcgcggcgctgccggagggcaaggccggcaaacgcgcgccggcggcagccagggcctcg
ccgccggactcgccgcgggcttactcggctgagagaactgcggagaccagggcgccgggc
gccaagcagctaacgaaccacagcccgccggcgcccagacatgggccggttcccgcagaa
gccccggagctcaaagcccaggagcccctcaggaagcagagccgcctggaccccagctcg
gcggtcctcatgcggaaggccaagcgcgagaaggtggagaccatgctgcggaacgactct
ttgagctcagaccagtccgagtcggtgcggccgtccccgcccaagccgcaccggtccaag
agaggcggcaagaagcggcagatgtcggtgagcagctctgaggaggagggcgtgtcgacg
cccgagtacaccagctgcgaggacgtggagctggagagcgagagcgtcagcgagaaaggt
gatttggattattactggttggatcctgccacgtggcacagccgggagacatcacctatt
agttcgcatcctgtaacgtggcaaccatctaaagagggggaccgattaattggacgtgtt
attcttaacaagagaacaaccatgcccaaagactcaggtgcattgctgggtctgaaagtt
gttggaggaaaaatgactgacttaggacgacttggtgctttcatcaccaaagtaaagaag
ggtagcctagcagatgtagttggacacctaagagcaggggatgaagttctagaatggaat
ggtaaacccctgccgggagctacaaatgaagaagtttacaacattattttagaatcaaaa
tcagaacctcaagttgaaattattgtttcaaggcctattggtgacattccccggattcct
gagagctcccaccctccactggagtccagttcaagttcctttgaatctcagaagatggaa
aggccttccatttctgttatttctccaacaagtcctggagctctaaaagatgccccacaa
gtcttaccagggcaactttctgtgaagttgtggtatgataaagtgggacaccagctgatt
gtaaatgttctgcaagcaacagatctacctgctagagtagatggacgtcctcgaaatccc
tatgtaaaaatgtattttcttccagatagaagtgataaaagtaaaaggaggaccaaaaca
gtaaagaaaatactagaaccaaaatggaatcaaacttttgtctattcacatgtacatcgt
agagattttagagaacgaatgttagaaataactgtgtgggaccaaccaagagtgcaagaa
gaagaaagtgaatttcttggagagatcctcatagaattggagacagcgcttttagatgat
gaaccgcattggtataaacttcagacacatgatgagtcttcactacctctgcctcagcca
tcacctttcatgccaaggcgacatattcatggagaaagctctagcaaaaagctacaaaga
tctcagcgaatcagtgatagtgacatctcagattatgaggttgatgatggtattggcgta
gttcctccagtaggctataggtctagtgctagagaaagtaaatctacaacattaactgtg
ccagaacagcaaagaacaactcatcaccgctcacgttcagtatctcctcatcgcggcaat
gatcagggaaagccgcgttcacgtttaccaaatgtgccattacagaggagtttagatgaa
attcatccaacaagaaggtcacgttctccaaccagacaccatgatgcctcccgaagtcca
gttgatcatagaaccagagatgtggatagtcagtatttatcagaacaagacagtgagctt
cttatgctgcccagagcaaaacgaggacgaagtgcagaatgcctacatactaccagacat
cttgttaggcactataaaacattacctcccaagatgcctttattacagagcagttctcac
tggaatatttacagctcaattctgcctgcacatactaagaccaaatcagtgactagacag
gacatttcccttcatcatgaatgctttaactcaacagtattgagatttactgatgaaata
ctggttagtgaactgcagccctttcttgacagggctaggagtgctagtaccaactgcttg
agaccagatactagtttgcattcaccagaacgagaaaggggtagatggtccccctcccta
gataggagacgacctcctagtcccaggattcaaatccagcatgcgtctccggagaatgac
aggcactccagaaagtctgaaagatctagcatccaaaaacagactaggaaaggcactgcc
tctgatgcagaaagggttctcccaacatgtctttctagaaggggacacgcagccccaaga
gcaactgatcagccagtcattaggggaaaacatcctgctcgctcaaggtcgagtgagcac
tctagtatcagaacactgtgttctatgcaccaccttgtccctggagggtcggcgccacct
tctccgcttctgacaagaatgcaccgacagagaagtccaacacaatctcctccagcagac
acatcgttcagcagtcgcaggggaagacagctcccacaagtgccagtgagaagcggcagt
atagaacaagcaagcttagtagtggaggagcgaacaagacagatgaaaatgaaagtgcat
cgatttaagcagacaacagggtctggttctagtcaagaacttgatcgcgagcaatattcc
aagtataacatacataaagatcagtacagaagctgtgataacgtctctgccaaatcatca
gatagtgatgtcagtgatgtttccgccatttcccgaaccagcagtgcctcacgcctcagc
agcacaagctttatgtcagagcaatctgagcgccccaggggtagaatcagttcatttacc
cccaaaatgcaaggcagacggatggggacttcaggaagatccatcatgaagagcaccagt
gtcagtggagagatgtacacactggagcataatgacggcagccagtcagacacagctgtg
ggtacagttggagcaggtggaaagaaacggagatccagccttagtgccaaagtggttgcc
atagtgtctcgaaggagtagaagcacatcccagcttagtcaaacagagtcgggccacaaa
aagttaaaaagtaccatccagagaagcacagaaacaggcatggcagctgaaatgagaaag
atggtaaggcagccgagccgagagtctactgatggcagcatcaacagttacagctctgag
ggcaatttaatatttcctggagtgcgactgggagctgacagtcaattcagtgattttctt
gatggattgggaccagcccagcttgttggccgccaaacccttgccacccctgcaatgggt
gatatacaaataggaatggaggacaaaaagggccaattagaagtggaagtcattagagca
cgaagcctcacacaaaagcctggttccaaatctacacctgctccatatgtcaaagtatat
cttttggaaaatggggcctgtatagccaagaagaagacaagaattgcacgaaaaaccctt
gatcctttgtatcagcagtctctggtttttgatgaaagtccacagggtaaagttcttcag
gtgattgtctggggagactatggcagaatggaccacaaatgctttatgggtgtggctcag
atcttgttggaagaactcgacctgtccagcatggtgatcggatggtacaaattgttccca
ccgtcctcactggtggatcccacactcactcccctcacccggcgggcttcccagtcatct
ctggaaagttcaactgggcctccctgtattcgatcatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (122)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (118)   
DNA sequence (172)   
   RefSeq(nuc) (118)   
   GenBank (27)   
   EMBL (27)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (335)   

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