KEGG   Homo sapiens (human): 23007
Entry
23007             CDS       T01001                                 
Symbol
PLCH1, HPE14, PLC_eta_1, PLC-L3, PLCL3
Name
(RefSeq) phospholipase C eta 1
  KO
K19006  phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
Disease
H00267  Holoprosencephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    23007 (PLCH1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23007 (PLCH1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     23007 (PLCH1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    23007 (PLCH1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    23007 (PLCH1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y C2 EF-hand_like EF-hand_7 EF-hand_1 PH_12 EF-hand_6 EF-hand_8 EF-hand_10 EF-hand_5 AIF-1 PH EF-hand_4 SPARC_Ca_bdg
Other DBs
NCBI-GeneID: 23007
NCBI-ProteinID: NP_001124432
OMIM: 612835
HGNC: 29185
Ensembl: ENSG00000114805
UniProt: Q4KWH8
Position
3:complement(155450934..155745071)
AA seq 1693 aa
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE
KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI
TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR
RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL
KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD
MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG
YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS
VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN
GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG
KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE
LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY
RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP
FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR
VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY
LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS
SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT
TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLN
FNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCP
SKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEG
NRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALI
GQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIA
LSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPT
KGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREG
TSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGA
GFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTS
EDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQV
LYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPS
APTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPS
SDDKPEIYFLLRL
NT seq 5082 nt   +upstreamnt  +downstreamnt
atggcagaccttgaagtgtataaaaacttaagtccagaaaaagttgaaagatgcatgagt
gtgatgcagtccgggacacagatgatcaagctgaaacgtggaaccaaagggcttgtccgc
ctcttttacctggatgagcaccggacacgcctccgatggcgaccctctaggaagagtgag
aaggcaaaaatacttattgattccatttacaaagtgactgagggccggcagtctgaaata
ttccacagacaagctgaggggaacttcgaccccagctgctgcttcaccatctaccatggc
aaccacatggagtccctggacctcatcacctccaaccccgaggaggcccgcacctggatc
acaggcctcaagtacctgatggctggcatcagtgatgaagactcccttgccaaaaggcag
aggacccatgaccaatgggtgaagcagacctttgaggaagctgataagaatggtgacggc
ttgctgaatattgaagagatacatcagctgatgcataaactgaatgttaatctgccccga
agaaaagtcagacaaatgtttcaggaagccgacacagatgagaatcagggaactttgaca
tttgaagagttctgtgttttttacaaaatgatgtctttgagacgagacctttatttgtta
cttttgagctacagtgacaagaaagatcacctaactgtggaagaactggctcagtttttg
aaggtggagcaaaagatgaataatgtgacaacggactattgtcttgacatcataaagaag
tttgaagtttcagaagaaaataaggtgaaaaatgttcttggcatagaaggcttcacgaac
ttcatgcgtagtcctgcctgtgacatatttaacccattgcaccatgaagtgtaccaagac
atggatcagcccctctgcaactactacattgcttcctctcacaatacatacctgactgga
gaccagctcctttctcagtccaaagtggatatgtatgcacgggtgctgcaagagggctgt
cgctgtgtggaagttgactgttgggatggcccagatggagagccagtagtacatcatggt
tacactctcacttcaaaaattctcttcagagatgttgtggagaccatcaacaagcatgcc
tttgtgaagaatgagtttcctgttatattgtctatcgagaatcactgcagtatccagcag
caaaggaagattgctcagtacctgaaaggaatattcggagacaaactggacctgtcatct
gttgatacaggggagtgcaagcagcttccaagccctcaaagtttgaaaggcaaaattcta
gtgaagggtaagaagttgccttatcaccttggggatgatgcagaggaaggggaagtttct
gatgaggacagtgcagatgaaattgaagacgagtgcaaattcaagctccattatagtaat
gggaccactgagcatcaggtggaatctttcataaggaaaaaactggagtcactgttaaaa
gaatctcaaattcgagataaagaagatcctgatagtttcacagtgcgggcactactgaag
gccacgcatgaaggcttaaatgcacacctgaagcagagtccagatgtaaaggaaagtgga
aagaaatcacatggacgatccctcatgaccaactttggaaaacataagaaaactacaaaa
tcacggtctaaatcttacagtactgatgatgaggaagacacacagcagagtactggcaag
gagggtggccagctgtacagattgggtcgccgaaggaaaaccatgaagctctgccgagaa
ctctctgatttggttgtgtacacaaactccgtggccgctcaggacattgtggatgacgga
accacaggaaatgtgttatcattcagtgaaacaagagcacatcaggttgttcagcaaaaa
tcagagcagttcatgatttataatcaaaagcaactcacgaggatttacccctctgcctac
cgcattgattccagtaacttcaaccctctcccctactggaacgcaggctgccagctagtg
gcactgaattatcaatctgaaggacgaatgatgcagttaaaccgagccaaattcaaggca
aatggcaattgtggctatgtcctcaaaccccagcaaatgtgcaaaggtactttcaaccct
ttctctggtgaccctcttcctgccaaccccaaaaagcagctcatcctgaaagttatcagt
ggacagcaactccccaaacctccagactccatgtttggagatcgaggcgagatcattgac
ccttttgttgaagttgaaattattggattgccagtagattgttgtaaagatcaaacccgt
gtggtagatgacaatggatttaaccctgtgtgggaagaaacactgacatttacagtacac
atgccagaaatagctttggttcggttccttgtgtgggatcacgatcccattggacgagac
tttgttggacaaagaactgtgaccttcagcagcttagtgcctggctaccggcatgtctat
ttggaaggactgacagaagcatccatatttgtacacataaccatcaatgaaatctatgga
aagtggagccctttaatactcaaccccagttatactatattgcactttctaggagctaca
aagaacagacaactccagggtctgaagggactgttcaataagaatcctaggcacagttct
tcagaaaacaattcccattatgtacggaagcgatccattggagatagaattctgcgacgc
acagctagcgccccagccaaaggcaggaaaaagagcaaaatgggcttccaagaaatggtg
gagataaaggattctgtgtccgaggccacaagagatcaagatggcgtgctgaggaggacc
acacgcagtttgcaagcacgccctgtctctatgcctgttgacagaaaccttctgggagct
ttgtcgctgcctgtatctgaaacagcaaaagacattgaaggaaaagaaaactctctagca
gaagataaagatggcagaagaaaagggaaagcaagtataaaagatccacattttctaaat
ttcaacaaaaagttatcatcctcctccagtgctctgctccacaaagataccagccaaggg
gacaccattgtatctactgcccacatgtcagtcacaggagaacagctgggcatgtcaagt
cctaggggtgggagaaccacatcaaatgccacaagcaattgccaggaaaacccctgtccc
agcaagtctctctccccaaagcagcatttggctcccgatcctgtagttaaccccacacaa
gatctgcatggtgtgaaaatcaaggaaaagggtaatcctgaggactttgtggaagggaaa
agcatcttgtcaggaagcgtcctttctcatagcaacctagaaattaagaacctggaaggt
aataggggtaagggccgagctgcaacatccttttctttgtcagacgtctccatgctctgt
tctgacatacctgacctacattcaactgcaattctgcaggagagtgtaatttcccatctt
attgacaatgtcactttaacaaatgagaatgagccgggcagttccatctcagccctgatt
ggccagtttgatgagaccaacaatcaggctctcacagttgtttctcatcttcataatacc
agtgtgatgtcaggccattgtcccttgcctagcctgggcctaaaaatgcccatcaagcat
ggtttttgcaagggaaaatccaagtcttccttcctgtgctcatctccggagctgatagca
ctctcgagttctgagaccaccaaacatgcaacgaacacagtttatgaaactacctgcact
cccatctctaaaaccaaaccagatgatgacctttctagtaaggccaagacagcggcctta
gaaagcaacctgcctggatcccctaatacttctcgtggctggttaccaaaaagtcctacc
aagggagaagactgggaaacactgaagagctgcagccctgcctcttcccctgatttgacc
ctggaggatgtaatagctgatcccactctctgtttcaattctggggagagcagccttgtg
gaaattgatggagaatcagaaaatctttctctaacaacctgtgaatataggagagagggc
acaagtcaacttgcttctcctttaaaactcaagtacaatcagggtgtggtagaacacttt
caaagaggtttgagaaacggctactgtaaagagaccctccgcccttctgtccctgaaata
ttcaacaatattcaagatgtcaaaactcaaagtatttcttatctagcctatcagggtgct
ggctttgtgcataatcatttctcagattcagatgcaaaaatgttccagacctgtgtgccc
cagcaatctagtgctcaagatatgcatgtccctgtacccaagcagttggcacatcttcct
ttgcctgctctgaaactgcctagtccttgcaaatccaaaagtctgggggacttaacatca
gaggacattgcctgcaattttgagagcaagtaccagtgtattagtaagagttttgttaca
actggcattagagacaagaagggcgtgactgtgaagacaaagtcgttagagcctatagat
gccctgaccgagcagcttcggaagcttgtgtcctttgaccaggaagacaactgccaagtg
ctatattcaaagcaggatgccaatcagctcccccgggcactggtcaggaagttgtcatcc
agaagtcagagcagagtgcgcaatattgctagtcgtgccaaggagaaacaggaagccaac
aagcagaaagttccaaaccccagcaatggggcaggagtggttcttagaaacaaaccctca
gcacccacccctgcagtgaatcgccactccaccggctcctacatcgcaggctacctgaag
aacacgaaagggggtggccttgaaggccggggcatcccagagggggcatgcacggctctt
cactatggccacgttgaccagttttgttcagataattctgttttgcagactgagccaagc
agtgatgataaaccagaaatttattttcttttgagactgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (36)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (34)   
DNA sequence (52)   
   RefSeq(nuc) (34)   
   GenBank (9)   
   EMBL (9)   
Protein domain (15)   
   Pfam (15)   
All databases (150)   

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