KEGG   Homo sapiens (human): 23293
Entry
23293             CDS       T01001                                 
Symbol
SMG6, C17orf31, EST1A, SMG-6, hEST1A, hSMG5/7a
Name
(RefSeq) SMG6 nonsense mediated mRNA decay factor
  KO
K11124  protein SMG6 [EC:3.1.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    23293 (SMG6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    23293 (SMG6)
   03032 DNA replication proteins [BR:hsa03032]
    23293 (SMG6)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Other surveillance factors
     23293 (SMG6)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     23293 (SMG6)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Telomerase complex (animals)
    23293 (SMG6)
SSDB
Motif
Pfam: EST1_DNA_bind PIN_4 EST1 PIN_9
Other DBs
NCBI-GeneID: 23293
NCBI-ProteinID: NP_060045
OMIM: 610963
HGNC: 17809
Ensembl: ENSG00000070366
UniProt: Q86US8
Structure
Position
17:complement(2059839..2303785)
AA seq 1419 aa
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLR
NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQES
FPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGS
AKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSS
TDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVN
SAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTD
DEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS
RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVK
DPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTR
RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKK
STFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFS
EECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLK
ELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK
DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCG
QEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGED
DIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLA
SLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES
RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPI
RLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG
NT seq 4260 nt   +upstreamnt  +downstreamnt
atggcggaagggctggagcgtgtgcggatctccgcgtcggagctgcgcgggatcctggct
actctggccccgcaggccgggagcagagaaaacatgaaggaattaaaggaggccaggccg
cgcaaagataacaggcgtccagatctggaaatctataagcctggcctttctcggctaagg
aacaagcccaaaatcaaggaaccccctgggagtgaggaattcaaagatgaaattgttaat
gaccgagattgctctgctgttgaaaatggtacacagcccgttaaagatgtctgcaaggaa
ctgaacaaccaagagcagaatggtcctatagacccagaaaataatcggggacaagaatcc
tttcctaggactgctggacaagaggatcgtagtctaaaaattatcaaaagaacaaagaaa
cccgacctgcagatctatcagcctggacgacgtttgcagactgttagcaaagaatccgcc
agtcgggtggaggaggaagaagtcctcaaccaggtagaacaactgagagtagaggaagat
gagtgtaggggaaatgttgcgaaggaggaagttgcgaataaaccagacagggctgagata
gaaaagagcccaggtggtgggagagtaggggctgcaaaaggagaaaaaggaaagaggatg
ggaaaaggggagggggtgagggaaacccacgacgacccagcccgcgggaggccgggctcc
gcaaagcgctactcccgctcagacaaacgaaggaatcgctaccgcacgcgcagcaccagc
tcagctggcagcaacaacagcgctgagggagctggcctgacggataatggatgtcgccgc
cgccgacaggataggaccaaggagaggccacgactgaagaagcaagtgtctgtgtcctca
accgattccttagacgaggacagaattgatgagcctgatggattaggacccaggagaagt
tcagaaaggaagagacatttagaaagaaactggtctggccgtggggagggtgagcagaaa
aacagtgctaaagaatatcgaggcactcttcgtgtcactttcgatgcagaagccatgaac
aaagagtctcccatggtgaggtcagccagggatgatatggatagaggaaagcctgacaaa
ggcttgagcagtgggggcaaaggctctgagaagcaggagtccaaaaacccgaaacaagaa
cttcggggtcgtggtcgtggcattctgattttgcctgcccataccaccctatctgtcaat
tcagcaggttctccagagtccgcgcctttgggacctcggcttttgtttggatctggtagt
aagggatctcggagttggggccgtggaggcaccacacgccgattgtgggacccaaacaat
cctgatcagaaacctgctctaaagactcagacgccccagctacatttcttggacactgat
gatgaagtcagccctacatcttggggtgactcacgccaggctcaggcatcttactataag
tttcaaaactctgacaacccctattattacccccggacaccaggccctgcctcccagtat
ccctatacgggctataaccctctacagtacccagtgggccctacgaatggtgtgtaccca
gggccttactacccaggctacccgactccgtcaggacagtatgtgtgtagccctctacct
accagcaccatgagtcccgaggaggtagagcagcacatgaggaacctgcagcaacaggag
ctgcacaggcttctccgggtggctgacaaccaggaactgcagctcagcaacctgctctcc
agggaccgcatcagtccggagggcctggagaagatggcgcaactcagagctgaactgctg
cagctatatgagcgctgtattctattagatattgagttctctgataatcagaatgtggat
cagatcctgtggaagaatgctttctatcaggtgattgagaagttcaggcaacttgtcaag
gatccgaatgttgagaacccagaacagattcggaacagacttttggagctcttggatgag
ggtagtgacttctttgatagtttgcttcagaagctgcaggttacttacaagttcaaactg
gaagactacatggatggtcttgccattcgcagcaagccattacgcaagacagtaaaatat
gccttgatcagtgcccagcgatgcatgatatgccaaggagatattgctaggtaccgggag
caagccagtgatacagcgaattatgggaaagcacgcagttggtacctgaaggcccagcac
attgctcccaagaatgggcgcccctataaccagttggctttgctggcagtgtatacgagg
aggaagcttgacgctgtctattactatatgcgcagtttagctgccagcaaccctatcctg
actgccaaggagagtctcatgagcttgtttgaagagaccaagcggaaggcagaacagatg
gaaaagaagcaacatgaggaatttgacctgagccctgaccagtggcggaaaggaaagaag
tctactttccggcatgttggagatgacaccactcgcctggagatctggattcatccatcc
catccacggtcttcccagggcactgagtctgggaaggattctgagcaagagaatgggctg
ggcagcctgagtcccagtgatctgaacaaaaggttcatcctcagttttctccatgcccat
gggaagctgtttacccggattgggatggagacattccctgcagtggctgagaaggtcctc
aaggagttccaggtgttactgcagcacagcccctctcccattggaagtacccgcatgctg
cagcttatgaccatcaatatgtttgcagtacacaactcccagctgaaagactgcttctcg
gaggagtgccgctctgtgatccaggaacaagccgcagctctgggcttggccatgttttct
ctactggtccgccgctgcacctgcttacttaaggagtccgccaaagctcagctgtcctct
cctgaggaccaggatgaccaagacgacatcaaggtgtcttcctttgtcccggacctgaag
gagctgctccccagtgtcaaagtctggtcagattggatgctcggctacccggacacctgg
aatcctcctcccacatccctggatctgccctcgcatgttgctgtggatgtatggtcgacg
ctggctgatttctgtaacatactgactgcagtgaatcagtctgaggtgccactgtacaag
gacccggatgatgacctcacccttcttatcctggaagaggatcggcttctctcgggcttt
gtccccttgctggctgcccctcaggacccctgctacgtggagaaaacctcggataaggtt
attgcagctgactgcaaaagggtcacagtgctgaagtattttctggaagccctttgtgga
caagaagagcctctgctggcattcaagggtggaaagtatgtgtcagtggcacccgtccca
gacaccatgggaaaggaaatgggaagccaagagggaacacgactggaagatgaggaggag
gatgtggtgattgaagactttgaggaagattcagaggctgaaggcagcggaggcgaggat
gacatcagggagcttcgggccaagaagctggctctggccaggaagatagctgagcagcag
cgtcgccaggaaaagatccaggctgtcctggaggaccacagtcagatgaggcagatggag
ctcgaaatcagacctttgttcctcgtaccagacaccaacggcttcattgaccacctggcc
agtctggcgcggctgctggagagcaggaagtacatcctggtggtgcccctcatcgtgatc
aatgagctggacggcctggccaaggggcaggagacagaccaccgggctgggggctacgcc
cgtgtggtacaagagaaggcccgcaagtccatcgagttcctcgagcagcgattcgagagt
cgggactcttgcctgcgagccctgaccagccgtggcaatgaactcgaatccatcgccttc
cgcagtgaggacatcactggccagctgggtaacaacgatgatctcatcctgtcctgctgc
ctccactactgcaaagacaaggctaaggacttcatgcccgccagcaaagaggagccaatc
cggctactgcgggaggtggtgctgttgacggatgaccggaacctgcgtgtgaaggcgctc
acaaggaatgttcctgtacgggacatcccagccttcctcacgtgggcccaggtgggctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (33)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (31)   
DNA sequence (58)   
   RefSeq(nuc) (32)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   Pfam (4)   
All databases (126)   

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