KEGG   Homo sapiens (human): 23327
Entry
23327             CDS       T01001                                 
Symbol
NEDD4L, NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2
Name
(RefSeq) NEDD4 like E3 ubiquitin protein ligase
  KO
K13305  E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04144  Endocytosis
hsa04530  Tight junction
hsa04960  Aldosterone-regulated sodium reabsorption
Disease
H00270  Periventricular nodular heterotopia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    23327 (NEDD4L)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    23327 (NEDD4L)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    23327 (NEDD4L)
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    23327 (NEDD4L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23327 (NEDD4L)
   04121 Ubiquitin system [BR:hsa04121]
    23327 (NEDD4L)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     23327 (NEDD4L)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    23327 (NEDD4L)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   23327 (NEDD4L)
SSDB
Motif
Pfam: HECT WW C2
Other DBs
NCBI-GeneID: 23327
NCBI-ProteinID: NP_001138439
OMIM: 606384
HGNC: 7728
Ensembl: ENSG00000049759
UniProt: Q96PU5
Structure
Position
18:58044226..58401540
AA seq 975 aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL
VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP
TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI
NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS
RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPA
GRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP
QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT
SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK
YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY
GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA
VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE
NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI
KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ
FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK
LLMAVENAQGFEGVD
NT seq 2928 nt   +upstreamnt  +downstreamnt
atggcgaccgggctcggggagccggtctatggactttccgaagacgagggagagtcccgt
attctcagagtaaaagttgtttctggaattgatctcgccaaaaaggacatctttggagcc
agtgatccgtatgtgaaactttcattgtacgtagcggatgagaatagagaacttgctttg
gtccagacaaaaacaattaaaaagacactgaacccaaaatggaatgaagaattttatttc
agggtaaacccatctaatcacagactcctatttgaagtatttgacgaaaatagactgaca
cgagacgacttcctgggccaggtggacgtgccccttagtcaccttccgacagaagatcca
accatggagcgaccctatacatttaaggactttctcctcagaccaagaagtcataagtct
cgagttaagggatttttgcgattgaaaatggcctatatgccaaaaaatggaggtcaagat
gaagaaaacagtgaccagagggatgacatggagcatggatgggaagttgttgactcaaat
gactcggcttctcagcaccaagaggaacttcctcctcctcctctgcctcccgggtgggaa
gaaaaagtggacaatttaggccgaacttactatgtcaaccacaacaaccggaccactcag
tggcacagaccaagcctgatggacgtgtcctcggagtcggacaataacatcagacagatc
aaccaggaggcagcacaccggcgcttccgctcccgcaggcacatcagcgaagacttggag
cccgagccctcggagggcggggatgtccccgagccttgggagaccatttcagaggaagtg
aatatcgctggagactctctcggtctggctctgcccccaccaccggcctccccaggatct
cggaccagccctcaggagctgtcagaggaactaagcagaaggcttcagatcactccagac
tccaatggggaacagttcagctctttgattcaaagagaaccctcctcaaggttgaggtca
tgcagtgtcaccgacgcagttgcagaacagggccatctaccaccgcccagtgccccagct
gggagagcgcgttcatcaactgtcacgggtggtgaggaaccaacgccatcagtggcctat
gtacataccacgccgggtctgccttcaggctgggaagaaagaaaagatgctaaggggcgc
acatactatgtcaatcataacaatcgaaccacaacttggactcgacctatcatgcagctt
gcagaagatggtgcgtccggatcagccacaaacagtaacaaccatctaatcgagcctcag
atccgccggcctcgtagcctcagctcgccaacagtaactttatctgccccgctggagggt
gccaaggactcacccgtacgtcgggctgtgaaagacaccctttccaacccacagtcccca
cagccatcaccttacaactcccccaaaccacaacacaaagtcacacagagcttcttgcca
cccggctgggaaatgaggatagcgccaaacggccggcccttcttcattgatcataacaca
aagactacaacctgggaagatccacgtttgaaatttccagtacatatgcggtcaaagaca
tctttaaaccccaatgaccttggcccccttcctcctggctgggaagaaagaattcacttg
gatggccgaacgttttatattgatcataatagcaaaattactcagtgggaagacccaaga
ctgcagaacccagctattactggtccggctgtcccttactccagagaatttaagcagaaa
tatgactacttcaggaagaaattaaagaaacctgctgatatccccaataggtttgaaatg
aaacttcacagaaataacatatttgaagagtcctatcggagaattatgtccgtgaaaaga
ccagatgtcctaaaagctagactgtggattgagtttgaatcagagaaaggtcttgactat
gggggtgtggccagagaatggttcttcttactgtccaaagagatgttcaacccctactac
ggcctctttgagtactctgccacggacaactacacccttcagatcaaccctaattcaggc
ctctgtaatgaggatcatttgtcctacttcacttttattggaagagttgctggtctggcc
gtatttcatgggaagctcttagatggtttcttcattagaccattttacaagatgatgttg
ggaaagcagataaccctgaatgacatggaatctgtggatagtgaatattacaactctttg
aaatggatcctggagaatgaccctactgagctggacctcatgttctgcatagacgaagaa
aactttggacagacatatcaagtggatttgaagcccaatgggtcagaaataatggtcaca
aatgaaaacaaaagggaatatatcgacttagtcatccagtggagatttgtgaacagggtc
cagaagcagatgaacgccttcttggagggattcacagaactacttcctattgatttgatt
aaaatttttgatgaaaatgagctggagttgctcatgtgcggcctcggtgatgtggatgtg
aatgactggagacagcattctatttacaagaacggctactgcccaaaccaccccgtcatt
cagtggttctggaaggctgtgctactcatggacgccgaaaagcgtatccggttactgcag
tttgtcacagggacatcgcgagtacctatgaatggatttgccgaactttatggttccaat
ggtcctcagctgtttacaatagagcaatggggcagtcctgagaaactgcccagagctcac
acatgctttaatcgccttgacttacctccatatgaaacctttgaagatttacgagagaaa
cttctcatggccgtggaaaatgctcaaggatttgaaggggtggattaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (90)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (88)   
DNA sequence (164)   
   RefSeq(nuc) (88)   
   GenBank (38)   
   EMBL (38)   
3D Structure (17)   
   PDB (17)   
Protein domain (3)   
   Pfam (3)   
All databases (320)   

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