KEGG   Homo sapiens (human): 23476
Entry
23476             CDS       T01001                                 
Symbol
BRD4, CAP, CDLS6, FSHRG4, HUNK1, HUNKI, MCAP
Name
(RefSeq) bromodomain containing 4
  KO
K11722  bromodomain-containing protein 4
Organism
hsa  Homo sapiens (human)
Network
nt06512  Chromosome cohesion and segregation
  Element
N01813  Enhancement of NIPBL loading
Disease
H00631  Cornelia de Lange syndrome
Drug target
Apabetalone: D11131
Birabresib: D10911
Ezobresib: D12710
Mivebresib: D11479
Molibresib (DG02993): D11326 D11347
Pelabresib: D12266
Trotabresib: D12006
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    23476 (BRD4)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    23476 (BRD4)
   03036 Chromosome and associated proteins [BR:hsa03036]
    23476 (BRD4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  BRD family [OT]
   23476 (BRD4)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Brd4/P-TEFb complex
     23476 (BRD4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   Other chromatin remodeling factors
    23476 (BRD4)
SSDB
Motif
Pfam: Bromodomain BET BRD4_CDT
Other DBs
NCBI-GeneID: 23476
NCBI-ProteinID: NP_490597
OMIM: 608749
HGNC: 13575
Ensembl: ENSG00000141867
UniProt: O60885
Structure
Position
19:complement(15235519..15332539)
AA seq 1362 aa
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
NT seq 4089 nt   +upstreamnt  +downstreamnt
atgtctgcggagagcggccctgggacgagattgagaaatctgccagtaatgggggatgga
ctagaaacttcccaaatgtctacaacacaggcccaggcccaaccccagccagccaacgca
gccagcaccaaccccccgcccccagagacctccaaccctaacaagcccaagaggcagacc
aaccaactgcaatacctgctcagagtggtgctcaagacactatggaaacaccagtttgca
tggcctttccagcagcctgtggatgccgtcaagctgaacctccctgattactataagatc
attaaaacgcctatggatatgggaacaataaagaagcgcttggaaaacaactattactgg
aatgctcaggaatgtatccaggacttcaacactatgtttacaaattgttacatctacaac
aagcctggagatgacatagtcttaatggcagaagctctggaaaagctcttcttgcaaaaa
ataaatgagctacccacagaagaaaccgagatcatgatagtccaggcaaaaggaagagga
cgtgggaggaaagaaacagggacagcaaaacctggcgtttccacggtaccaaacacaact
caagcatcgactcctccgcagacccagacccctcagccgaatcctcctcctgtgcaggcc
acgcctcaccccttccctgccgtcaccccggacctcatcgtccagacccctgtcatgaca
gtggtgcctccccagccactgcagacgcccccgccagtgcccccccagccacaaccccca
cccgctccagctccccagcccgtacagagccacccacccatcatcgcggccaccccacag
cctgtgaagacaaagaagggagtgaagaggaaagcagacaccaccacccccaccaccatt
gaccccattcacgagccaccctcgctgcccccggagcccaagaccaccaagctgggccag
cggcgggagagcagccggcctgtgaaacctccaaagaaggacgtgcccgactctcagcag
cacccagcaccagagaagagcagcaaggtctcggagcagctcaagtgctgcagcggcatc
ctcaaggagatgtttgccaagaagcacgccgcctacgcctggcccttctacaagcctgtg
gacgtggaggcactgggcctacacgactactgtgacatcatcaagcaccccatggacatg
agcacaatcaagtctaaactggaggcccgtgagtaccgtgatgctcaggagtttggtgct
gacgtccgattgatgttctccaactgctataagtacaaccctcctgaccatgaggtggtg
gccatggcccgcaagctccaggatgtgttcgaaatgcgctttgccaagatgccggacgag
cctgaggagccagtggtggccgtgtcctccccggcagtgccccctcccaccaaggttgtg
gccccgccctcatccagcgacagcagcagcgatagctcctcggacagtgacagttcgact
gatgactctgaggaggagcgagcccagcggctggctgagctccaggagcagctcaaagcc
gtgcacgagcagcttgcagccctctctcagccccagcagaacaaaccaaagaaaaaggag
aaagacaagaaggaaaagaaaaaagaaaagcacaaaaggaaagaggaagtggaagagaat
aaaaaaagcaaagccaaggaacctcctcctaaaaagacgaagaaaaataatagcagcaac
agcaatgtgagcaagaaggagccagcgcccatgaagagcaagccccctcccacgtatgag
tcggaggaagaggacaagtgcaagcctatgtcctatgaggagaagcggcagctcagcttg
gacatcaacaagctccccggcgagaagctgggccgcgtggtgcacatcatccagtcacgg
gagccctccctgaagaattccaaccccgacgagattgaaatcgactttgagaccctgaag
ccgtccacactgcgtgagctggagcgctatgtcacctcctgtttgcggaagaaaaggaaa
cctcaagctgagaaagttgatgtgattgccggctcctccaagatgaagggcttctcgtcc
tcagagtcggagagctccagtgagtccagctcctctgacagcgaagactccgaaacagag
atggctccgaagtcaaaaaagaaggggcaccccgggagggagcagaagaagcaccatcat
caccaccatcagcagatgcagcaggccccggctcctgtgccccagcagccgcccccgcct
ccccagcagcccccaccgcctccacctccgcagcagcaacagcagccgccacccccgcct
cccccaccctccatgccgcagcaggcagccccggcgatgaagtcctcgcccccacccttc
attgccacccaggtgcccgtcctggagccccagctcccaggcagcgtctttgaccccatc
ggccacttcacccagcccatcctgcacctgccgcagcctgagctgccccctcacctgccc
cagccgcctgagcacagcactccaccccatctcaaccagcacgcagtggtctctcctcca
gctttgcacaacgcactaccccagcagccatcacggcccagcaaccgagccgctgccctg
cctcccaagcccgcccggcccccagccgtgtcaccagccttgacccaaacacccctgctc
ccacagccccccatggcccaacccccccaagtgctgctggaggatgaagagccacctgcc
ccacccctcacctccatgcagatgcagctgtacctgcagcagctgcagaaggtgcagccc
cctacgccgctactcccttccgtgaaggtgcagtcccagcccccaccccccctgccgccc
ccaccccacccctctgtgcagcagcagctgcagcagcagccgccaccacccccaccaccc
cagccccagcctccaccccagcagcagcatcagccccctccacggcccgtgcacttgcag
cccatgcagttttccacccacatccaacagcccccgccaccccagggccagcagcccccc
catccgcccccaggccagcagccacccccgccgcagcctgccaagcctcagcaagtcatc
cagcaccaccattcaccccggcaccacaagtcggacccctactcaaccggtcacctccgc
gaagccccctccccgcttatgatacattccccccagatgtcacagttccagagcctgacc
caccagtctccaccccagcaaaacgtccagcctaagaaacaggagctgcgtgctgcctcc
gtggtccagccccagcccctcgtggtggtgaaggaggagaagatccactcacccatcatc
cgcagcgagcccttcagcccctcgctgcggccggagccccccaagcacccggagagcatc
aaggcccccgtccacctgccccagcggccggaaatgaagcctgtggatgtcgggaggcct
gtgatccggcccccagagcagaacgcaccgccaccaggggcccctgacaaggacaaacag
aaacaggagccgaagactccagttgcgcccaaaaaggacctgaaaatcaagaacatgggc
tcctgggccagcctagtgcagaagcatccgaccaccccctcctccacagccaagtcatcc
agcgacagcttcgagcagttccgccgcgccgctcgggagaaagaggagcgtgagaaggcc
ctgaaggctcaggccgagcacgctgagaaggagaaggagcggctgcggcaggagcgcatg
aggagccgagaggacgaggatgcgctggagcaggcccggcgggcccatgaggaggcacgt
cggcgccaggagcagcagcagcagcagcgccaggagcaacagcagcagcagcaacagcaa
gcagctgcggtggctgccgccgccaccccacaggcccagagctcccagccccagtccatg
ctggaccagcagagggagttggcccggaagcgggagcaggagcgaagacgccgggaagcc
atggcagctaccattgacatgaatttccagagtgatctattgtcaatatttgaagaaaat
cttttctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (8)   
   KEGG DRUG (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG ORTHOLOGY (1)   
   RefGene (35)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (46)   
   RefSeq(nuc) (18)   
   GenBank (14)   
   EMBL (14)   
3D Structure (540)   
   PDB (540)   
Protein domain (3)   
   Pfam (3)   
All databases (668)   

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