KEGG   Homo sapiens (human): 23512
Entry
23512             CDS       T01001                                 
Symbol
SUZ12, CHET9, IMMAS, JJAZ1
Name
(RefSeq) SUZ12 polycomb repressive complex 2 subunit
  KO
K11463  polycomb protein SUZ12
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H02522  Imagawa-Matsumoto syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    23512 (SUZ12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23512 (SUZ12)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     23512 (SUZ12)
    PRC2.2
     23512 (SUZ12)
SSDB
Motif
Pfam: VEFS-Box DUF2070 Chorion_3
Other DBs
NCBI-GeneID: 23512
NCBI-ProteinID: NP_056170
OMIM: 606245
HGNC: 17101
Ensembl: ENSG00000178691
UniProt: Q15022
Structure
Position
17:31937007..32001038
AA seq 739 aa
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSA
AAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSH
RNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQN
SVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPS
NSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMT
VFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLR
WTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPN
ENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVY
HPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASM
SEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQI
EEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHL
VSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEK
ALETDSVSGVSKQSKKQKL
NT seq 2220 nt   +upstreamnt  +downstreamnt
atggcgcctcagaagcacggcggtgggggagggggcggctcggggcccagcgcggggtcc
gggggaggcggcttcgggggttcggcggcggtggcggcggcgacggcttcgggcggcaaa
tccggcggcgggagctgtggagggggtggcagttactcggcctcctcctcctcctccgcg
gcggcagcggcgggggctgcggtgttaccggtgaagaagccgaaaatggagcacgtccag
gctgaccacgagcttttcctccaggcctttgagaagccaacacagatctatagatttctt
cgaactcggaatctcatagcaccaatatttttgcacagaactcttacttacatgtctcat
cgaaactccagaacaaacatcaaaaggaaaacatttaaagttgatgatatgttatcaaaa
gtagagaaaatgaaaggagagcaagaatctcatagcttgtcagctcatttgcagcttacg
tttactggtttcttccacaaaaatgataagccatcaccaaactcagaaaatgaacaaaat
tctgttaccctggaagtcctgcttgtgaaagtttgccacaaaaaaagaaaggatgtaagt
tgtccaataaggcaagttcccacaggtaaaaagcaggtgcctttgaatcctgacctcaat
caaacaaaacccggaaatttcccgtcccttgcagtttccagtaatgaatttgaacctagt
aacagccatatggtgaagtcttactcgttgctatttagagtgactcgtccaggaagaaga
gagtttaatggaatgattaatggagaaaccaatgaaaatattgatgtcaatgaagagctt
ccagccagaagaaaacgaaatcgtgaggatggggaaaagacatttgttgcacaaatgaca
gtatttgataaaaacaggcgcttacagcttttagatggggaatatgaagtagccatgcag
gaaatggaagaatgtccaataagcaagaaaagagcaacatgggagactattcttgatggg
aagaggctgcctccattcgaaacattttctcagggacctacgttgcagttcactcttcgt
tggacaggagagaccaatgataaatctacggctcctattgccaaacctcttgccactaga
aattcagagagtctccatcaggaaaacaagcctggttcagttaaacctactcaaactatt
gctgttaaagaatcattgactacagatctacaaacaagaaaagaaaaggatactccaaat
gaaaaccgacaaaaattaagaatattttatcagtttctctataacaacaatacaaggcaa
caaactgaagcaagagatgacctgcattgcccttggtgtactctgaactgccgcaaactt
tatagtttactcaagcatcttaaactctgccatagcagatttatcttcaactatgtttat
catccaaaaggtgctaggatagatgtttctatcaatgagtgttatgatggctcctatgca
ggaaatcctcaggatattcatcgccaacctggatttgcttttagtcgcaacggaccagtt
aagagaacacctatcacacatattcttgtgtgcaggccaaaacgaacaaaagcaagcatg
tctgaatttcttgaatctgaagatggggaagtagaacagcaaagaacatatagtagtggc
cacaatcgtctgtatttccatagtgatacctgcttacctctccgtccacaagaaatggaa
gtagatagtgaagatgaaaaggatcctgaatggctaagagaaaaaaccattacacaaatt
gaagagttttctgatgttaatgaaggagagaaagaagtgatgaaactctggaatctccat
gtcatgaagcatgggtttattgctgacaatcaaatgaatcatgcctgtatgctgtttgta
gaaaattatggacagaaaataattaagaagaatttatgtcgaaacttcatgcttcatcta
gtcagcatgcatgactttaatcttattagcataatgtcaatagataaagctgttaccaag
ctccgtgaaatgcagcaaaaattagaaaagggggaatctgcttcccctgcaaacgaagaa
ataactgaagaacaaaatgggacagcaaatggatttagtgaaattaactcaaaagagaaa
gctttggaaacagatagtgtctcaggggtttcaaaacagagcaaaaaacaaaaactctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (4)   
   KEGG NETWORK (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (32)   
   RefSeq(nuc) (12)   
   GenBank (10)   
   EMBL (10)   
3D Structure (19)   
   PDB (19)   
Protein domain (3)   
   Pfam (3)   
All databases (101)   

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