KEGG   Homo sapiens (human): 2539
Entry
2539              CDS       T01001                                 
Symbol
G6PD, G6PD1
Name
(RefSeq) glucose-6-phosphate dehydrogenase
  KO
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00030  Pentose phosphate pathway
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa05230  Central carbon metabolism in cancer
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle)
hsa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
Network
nt06026  Glutathione biosynthesis
  Element
N00905  NADP+ reduction
Disease
H00361  Malaria
H00668  Anemia due to disorders of glutathione metabolism
H01375  Glucose 6-phosphate dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    2539 (G6PD)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2539 (G6PD)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    2539 (G6PD)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    2539 (G6PD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2539 (G6PD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.49  glucose-6-phosphate dehydrogenase (NADP+)
     2539 (G6PD)
    1.1.1.363  glucose-6-phosphate dehydrogenase [NAD(P)+]
     2539 (G6PD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   2539 (G6PD)
  Exosomal proteins of colorectal cancer cells
   2539 (G6PD)
  Exosomal proteins of bladder cancer cells
   2539 (G6PD)
SSDB
Motif
Pfam: G6PD_C G6PD_N
Other DBs
NCBI-GeneID: 2539
NCBI-ProteinID: NP_001035810
OMIM: 305900
HGNC: 4057
Ensembl: ENSG00000160211
UniProt: P11413 A0A384NL00
Structure
Position
X:complement(154531390..154547569)
AA seq 515 aa
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
NT seq 1548 nt   +upstreamnt  +downstreamnt
atggcagagcaggtggccctgagccggacccaggtgtgcgggatcctgcgggaagagctt
ttccagggcgatgccttccatcagtcggatacacacatattcatcatcatgggtgcatcg
ggtgacctggccaagaagaagatctaccccaccatctggtggctgttccgggatggcctt
ctgcccgaaaacaccttcatcgtgggctatgcccgttcccgcctcacagtggctgacatc
cgcaaacagagtgagcccttcttcaaggccaccccagaggagaagctcaagctggaggac
ttctttgcccgcaactcctatgtggctggccagtacgatgatgcagcctcctaccagcgc
ctcaacagccacatgaatgccctccacctggggtcacaggccaaccgcctcttctacctg
gccttgcccccgaccgtctacgaggccgtcaccaagaacattcacgagtcctgcatgagc
cagataggctggaaccgcatcatcgtggagaagcccttcgggagggacctgcagagctct
gaccggctgtccaaccacatctcctccctgttccgtgaggaccagatctaccgcatcgac
cactacctgggcaaggagatggtgcagaacctcatggtgctgagatttgccaacaggatc
ttcggccccatctggaaccgggacaacatcgcctgcgttatcctcaccttcaaggagccc
tttggcactgagggtcgcgggggctatttcgatgaatttgggatcatccgggacgtgatg
cagaaccacctactgcagatgctgtgtctggtggccatggagaagcccgcctccaccaac
tcagatgacgtccgtgatgagaaggtcaaggtgttgaaatgcatctcagaggtgcaggcc
aacaatgtggtcctgggccagtacgtggggaaccccgatggagagggcgaggccaccaaa
gggtacctggacgaccccacggtgccccgcgggtccaccaccgccacttttgcagccgtc
gtcctctatgtggagaatgagaggtgggatggggtgcccttcatcctgcgctgcggcaag
gccctgaacgagcgcaaggccgaggtgaggctgcagttccatgatgtggccggcgacatc
ttccaccagcagtgcaagcgcaacgagctggtgatccgcgtgcagcccaacgaggccgtg
tacaccaagatgatgaccaagaagccgggcatgttcttcaaccccgaggagtcggagctg
gacctgacctacggcaacagatacaagaacgtgaagctccctgacgcctatgagcgcctc
atcctggacgtcttctgcgggagccagatgcacttcgtgcgcagcgacgagctccgtgag
gcctggcgtattttcaccccactgctgcaccagattgagctggagaagcccaagcccatc
ccctatatttatggcagccgaggccccacggaggcagacgagctgatgaagagagtgggt
ttccagtatgagggcacctacaagtgggtgaacccccacaagctctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (6)   
   KEGG MODULE (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (13)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (29)   
   RefSeq(nuc) (3)   
   GenBank (13)   
   EMBL (13)   
3D Structure (24)   
   PDB (24)   
Protein domain (2)   
   Pfam (2)   
All databases (118)   

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