KEGG   Homo sapiens (human): 255738
Entry
255738            CDS       T01001                                 
Symbol
PCSK9, FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Name
(RefSeq) proprotein convertase subtilisin/kexin type 9
  KO
K13050  proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04979  Cholesterol metabolism
Network
nt06320  APOB-LDLR signaling
  Element
N00336  PCSK9-mediated LDLR degradation
Disease
H00155  Familial hypercholesterolemia
H02505  Atherosclerosis
Drug target
Alirocumab: D10335<US>
Bococizumab: D10621
Evolocumab: D10557<JP/US>
Frovocimab: D11398
Inclisiran (DG03216): D11931 D12293<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    255738 (PCSK9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    255738 (PCSK9)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    255738 (PCSK9)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   255738 (PCSK9)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   255738 (PCSK9)
SSDB
Motif
Pfam: PCSK9_C1 PCSK9_C2 PCSK9_C3 Peptidase_S8 Inhibitor_I9
Other DBs
NCBI-GeneID: 255738
NCBI-ProteinID: NP_777596
OMIM: 607786
HGNC: 20001
Ensembl: ENSG00000169174
UniProt: Q8NBP7
Structure
Position
1:55039548..55064852
AA seq 692 aa
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
NT seq 2079 nt   +upstreamnt  +downstreamnt
atgggcaccgtcagctccaggcggtcctggtggccgctgccactgctgctgctgctgctg
ctgctcctgggtcccgcgggcgcccgtgcgcaggaggacgaggacggcgactacgaggag
ctggtgctagccttgcgttccgaggaggacggcctggccgaagcacccgagcacggaacc
acagccaccttccaccgctgcgccaaggatccgtggaggttgcctggcacctacgtggtg
gtgctgaaggaggagacccacctctcgcagtcagagcgcactgcccgccgcctgcaggcc
caggctgcccgccggggatacctcaccaagatcctgcatgtcttccatggccttcttcct
ggcttcctggtgaagatgagtggcgacctgctggagctggccttgaagttgccccatgtc
gactacatcgaggaggactcctctgtctttgcccagagcatcccgtggaacctggagcgg
attacccctccacggtaccgggcggatgaataccagccccccgacggaggcagcctggtg
gaggtgtatctcctagacaccagcatacagagtgaccaccgggaaatcgagggcagggtc
atggtcaccgacttcgagaatgtgcccgaggaggacgggacccgcttccacagacaggcc
agcaagtgtgacagtcatggcacccacctggcaggggtggtcagcggccgggatgccggc
gtggccaagggtgccagcatgcgcagcctgcgcgtgctcaactgccaagggaagggcacg
gttagcggcaccctcataggcctggagtttattcggaaaagccagctggtccagcctgtg
gggccactggtggtgctgctgcccctggcgggtgggtacagccgcgtcctcaacgccgcc
tgccagcgcctggcgagggctggggtcgtgctggtcaccgctgccggcaacttccgggac
gatgcctgcctctactccccagcctcagctcccgaggtcatcacagttggggccaccaat
gcccaagaccagccggtgaccctggggactttggggaccaactttggccgctgtgtggac
ctctttgccccaggggaggacatcattggtgcctccagcgactgcagcacctgctttgtg
tcacagagtgggacatcacaggctgctgcccacgtggctggcattgcagccatgatgctg
tctgccgagccggagctcaccctggccgagttgaggcagagactgatccacttctctgcc
aaagatgtcatcaatgaggcctggttccctgaggaccagcgggtactgacccccaacctg
gtggccgccctgccccccagcacccatggggcaggttggcagctgttttgcaggactgta
tggtcagcacactcggggcctacacggatggccacagccgtcgcccgctgcgccccagat
gaggagctgctgagctgctccagtttctccaggagtgggaagcggcggggcgagcgcatg
gaggcccaagggggcaagctggtctgccgggcccacaacgcttttgggggtgagggtgtc
tacgccattgccaggtgctgcctgctaccccaggccaactgcagcgtccacacagctcca
ccagctgaggccagcatggggacccgtgtccactgccaccaacagggccacgtcctcaca
ggctgcagctcccactgggaggtggaggaccttggcacccacaagccgcctgtgctgagg
ccacgaggtcagcccaaccagtgcgtgggccacagggaggccagcatccacgcttcctgc
tgccatgccccaggtctggaatgcaaagtcaaggagcatggaatcccggcccctcaggag
caggtgaccgtggcctgcgaggagggctggaccctgactggctgcagtgccctccctggg
acctcccacgtcctgggggcctacgccgtagacaacacgtgtgtagtcaggagccgggac
gtcagcactacaggcagcaccagcgaaggggccgtgacagccgttgccatctgctgccgg
agccggcacctggcgcaggcctcccaggagctccagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Drug (6)   
   KEGG DRUG (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (40)   
   RefSeq(nuc) (18)   
   GenBank (11)   
   EMBL (11)   
3D Structure (43)   
   PDB (43)   
Protein domain (5)   
   Pfam (5)   
All databases (135)   

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