KEGG   Homo sapiens (human): 25930
Entry
25930             CDS       T01001                                 
Symbol
PTPN23, HD-PTP, HDPTP, NEDBASS, PTP-TD14
Name
(RefSeq) protein tyrosine phosphatase non-receptor type 23
  KO
K18040  tyrosine-protein phosphatase non-receptor type 23 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Disease
H02470  Neurodevelopmental disorder with structural brain abnormalities
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    25930 (PTPN23)
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    25930 (PTPN23)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     25930 (PTPN23)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    25930 (PTPN23)
Cilium and associated proteins [BR:hsa03037]
 Primary cilia and associated proteins
  Other primary cilia associated proteins
   25930 (PTPN23)
SSDB
Motif
Pfam: BRO1 Y_phosphatase ALIX_LYPXL_bnd Y_phosphatase3 DSPc PTPlike_phytase
Other DBs
NCBI-GeneID: 25930
NCBI-ProteinID: NP_056281
OMIM: 606584
HGNC: 14406
Ensembl: ENSG00000076201
UniProt: Q9H3S7
Structure
Position
3:47381021..47413435
AA seq 1636 aa
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR
DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN
LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL
MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL
VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL
VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ
LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA
GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL
PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK
LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA
SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP
TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST
GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ
HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN
PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ
PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP
GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP
SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL
LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD
AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV
ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH
QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL
HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA
TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE
EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS
DDPLSLLDPLWTLNKT
NT seq 4911 nt   +upstreamnt  +downstreamnt
atggaggccgtgccccgcatgcccatgatctggctggacctgaaggaggccggtgacttt
cacttccagccagctgtgaagaagtttgtcctgaagaattatggagagaacccagaagcc
tacaatgaagaactgaagaagctggagttgctcagacagaatgctgtccgtgtcccacga
gactttgagggctgtagtgtcctccgcaagtacctcggccagcttcattacctgcagagt
cgggtccccatgggctcgggccaggaggccgctgtccctgtcacctggacagagatcttc
tcaggcaagtctgtggcccatgaggacatcaagtacgagcaggcctgtattctctacaac
cttggagcgctgcactccatgctgggggccatggacaagcgggtgtctgaggagggcatg
aaggtctcctgtacccatttccagtgcgcagccggcgccttcgcctacctacgggagcac
ttccctcaagcctacagcgtcgacatgagccgccagatccttacgctcaacgtcaacctc
atgctgggccaggctcaggagtgcctcctggagaagtcgatgttggacaacaggaagagc
tttctggtggcccgcatcagtgcacaggtggtagattactacaaggaggcatgccgggcc
ttggagaaccccgacactgcctcactgctgggccggatccagaaggactggaagaaactt
gtgcagatgaagatctactacttcgcagccgtggctcatctgcacatgggaaagcaggcc
gaggagcagcagaagttcggggagcgggttgcatacttccagagcgccctggacaagctc
aatgaagccatcaagttggccaagggccagcctgacactgtgcaagacgcgcttcgcttc
actatggatgtcattgggggaaagtacaattctgccaagaaggacaacgacttcatttac
catgaggctgtcccagcattggacactcttcagcctgtaaaaggagcccccttggtgaag
cccttgccagtgaaccccacagacccagctgttacaggccctgacatctttgccaaactg
gtacccatggctgcccacgaggcctcgtcactgtacagtgaggagaaggccaagctgctc
cgggagatgatggccaagattgaggacaagaatgaggtcctggaccagttcatggattca
atgcagttggatcccgagacggtggacaaccttgatgcctacagccacatcccaccccag
ctcatggagaagtgcgcggctctcagcgtccggcccgacactgtcaggaaccttgtacag
tccatgcaagtgctgtcaggtgtgttcacggatgtggaggcttccctgaaggacatcaga
gatctgttggaggaggatgagctgctagagcagaagtttcaggaggcggtgggccaggca
ggggccatctccatcacctccaaggctgagctggcagaggtgaggcgagaatgggccaag
tacatggaagtccatgagaaggcctccttcaccaacagtgagctgcaccgtgccatgaac
ctgcacgtcggcaacctgcgcctgctcagcgggccgcttgaccaggtccgggctgccctg
cccacaccggccctctccccagaggacaaggccgtgctgcaaaacctaaagcgcatcctg
gctaaggtgcaggagatgcgggaccagcgcgtgtccctggagcagcagctgcgtgagctt
atccagaaagatgacatcactgcctcgctggtcaccacagaccactcagagatgaagaag
ttgttcgaggagcagctgaaaaagtatgaccagctgaaggtgtacctggagcagaacctg
gccgcccaggaccgtgtcctctgtgcactgacagaggccaacgtgcagtacgcagccgtg
cggcgggtactcagcgacttggaccaaaagtggaactccacgctgcagaccctggtggcc
tcgtatgaagcctatgaggacctgatgaagaagtcgcaggagggcagggacttctacgca
gatctggagagcaaggtggctgctctgctggagcgcacgcagtccacctgccaggcccgc
gaggctgcccgccagcagctcctggacagggagctgaagaagaagccgccgccacggccc
acagccccaaagccgctgctgccccgcagggaggagagtgaggcagtggaagcaggagac
ccccctgaggagctgcgcagcctcccccctgacatggtggctggcccacgactgcctgac
accttcctgggaagtgccaccccgctccactttcctcccagccccttccccagctccaca
ggcccaggaccccactatctctcaggccccttgccccctggtacctactcgggccccacc
cagctgatacagcccagggccccagggccccatgcaatgcccgtagcacctgggcctgcc
ctctacccagcccctgcctacacaccggagctgggccttgtgccccgatcctccccacag
catggcgtggtgagcagtccctatgtgggggtagggccggccccaccagttgcaggtctc
ccctcggccccacctcctcaattctcaggccccgagttggccatggcggttcggccagcc
accaccacagtagatagcatccaggcgcccatccccagccacacagccccacggccaaac
cccacccctgctcctcccccgccctgcttccctgtgcccccaccgcagccactgcccacg
ccttacacctaccctgcaggggctaagcaacccatcccggcacagcaccacttctcttct
gggatccccgcaggttttccagccccaaggattgggccccagccccagccccatcctcag
ccccatccttcacaagcgtttgggcctcagcccccacagcagccccttccactccagcat
ccacatctcttcccaccccaggccccaggactcctacccccacaatccccctacccctat
gcccctcagcctggggtcctggggcagccgccaccccccctacacacccagctctaccca
ggtcccgctcaagaccctctgccagcccactcaggggctctgcctttccccagccctggg
ccccctcagcctccccatcccccactggcatatggtcctgccccttctaccagacccatg
ggcccccaggcagcccctcttaccattcgagggccctcgtctgctggccagtccacccct
agtccccacctggtgccttcacctgccccatctccagggcctggtccggtaccccctcgc
cccccagcagcagaaccacccccttgcctgcgccgaggcgccgcagctgcagacctgctc
tcctccagcccggagagccagcatggcggcactcagtctcctgggggtgggcagcccctg
ctgcagcccaccaaggtggatgcagctgagggtcgtcggccgcaggccctgcggctgatt
gagcgggacccctatgagcatcctgagaggctgcggcagttgcagcaggagctggaggcc
tttcggggtcagctgggggatgtgggagctctggacactgtctggcgagagctgcaagat
gcgcaggaacatgatgcccgaggccgttccatcgccattgcccgctgctactcactgaag
aaccggcaccaggatgtcatgccctatgacagtaaccgtgtggtgctgcgctcaggcaag
gatgactacatcaatgccagctgcgtggaggggctctccccatactgccccccgctagtg
gcaacccaggccccactgcctggcacagctgctgacttctggctcatggtccatgagcag
aaagtgtcagtcattgtcatgctggtttctgaggctgagatggagaagcaaaaagtggca
cgctacttccccaccgagaggggccagcccatggtgcacggtgccctgagcctggcattg
agcagcgtccgcagcaccgaaacccatgtggagcgcgtgctgagcctgcagttccgagac
cagagcctcaagcgctctcttgtgcacctgcacttccccacttggcctgagttaggcctg
cccgacagccccagcaacttgctgcgcttcatccaggaggtgcacgcacattacctgcat
cagcggccgctgcacacgcccatcattgtgcactgcagctctggtgtgggccgcacggga
gcctttgcactgctctatgcagctgtgcaggaggtggaggctgggaacggaatccctgag
ctgcctcagctggtgcggcgcatgcggcagcagagaaagcacatgctgcaggagaagctg
cacctcaggttctgctatgaggcagtggtgagacacgtggagcaggtcctgcagcgccat
ggtgtgcctcctccatgcaaacccttggccagtgcaagcatcagccagaagaaccacctt
cctcaggactcccaggacctggtcctcggtggggatgtgcccatcagctccatccaggcc
accattgccaagctcagcattcggcctcctggggggttggagtccccggttgccagcttg
ccaggccctgcagagcccccaggcctcccgccagccagcctcccagagtctaccccaatc
ccatcttcctccccgccccccctttcctccccactacctgaggctccccagcctaaggag
gagccgccagtgcctgaagcccccagctcggggcccccctcctcctccctggaattgctg
gcctccttgaccccagaggccttctccctggacagctccctgcggggcaaacagcggatg
agcaagcataactttctgcaggcccataacgggcaagggctgcgggccacccggccctct
gacgaccccctcagccttctggatccactctggacactcaacaagacctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (65)   
   KEGG ORTHOLOGY (1)   
   RefGene (56)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (38)   
   RefSeq(nuc) (4)   
   GenBank (17)   
   EMBL (17)   
3D Structure (11)   
   PDB (11)   
Protein domain (6)   
   Pfam (6)   
All databases (135)   

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