KEGG   Homo sapiens (human): 25973
Entry
25973             CDS       T01001                                 
Symbol
PARS2, DEE75, EIEE75, MT-PRORS, proRS
Name
(RefSeq) prolyl-tRNA synthetase 2, mitochondrial
  KO
K01881  prolyl-tRNA synthetase [EC:6.1.1.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    25973 (PARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    25973 (PARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    25973 (PARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.15  proline---tRNA ligase
     25973 (PARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (C/G)
   25973 (PARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    25973 (PARS2)
 Prokaryotic type
    25973 (PARS2)
SSDB
Motif
Pfam: tRNA-synt_2b HGTP_anticodon Anti-TRAP
Other DBs
NCBI-GeneID: 25973
NCBI-ProteinID: NP_689481
OMIM: 612036
HGNC: 30563
Ensembl: ENSG00000162396
UniProt: Q7L3T8
Position
1:complement(54756898..54764523)
AA seq 475 aa
MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQ
DKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMP
SLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKLSYKQLPFL
LYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKLGLP
FVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLT
KTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDC
VRWPSLLAPYQACLIPPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGN
RLKDANKFGYPFVIIAGKRALEDPAHFEVWCQNTGEVAFLTKDGVMDLLTPVQTV
NT seq 1428 nt   +upstreamnt  +downstreamnt
atggaagggctgctgacaagatgcagagcattgcccgccctggccacctgcagccgccag
ctctctgggtatgttccttgcaggtttcaccactgtgccccaagaagagggcggcgcctg
ctgctgtctcgtgtgttccagccacagaaccttcgggaagaccgggtgctctccctgcag
gacaaatctgatgacctgacctgtaagagccagcggctgatgctgcaggtgggcctgatc
tacccagcaagccccggctgttaccacctcctgccatataccgtccgtgccatggagaag
ctcgtgcgagtgatagaccaggagatgcaggccatcgggggccagaaagtcaacatgccc
agcctcagcccggcagagctctggcaagccaccaaccggtgggacttgatgggcaaagag
ctgctaagacttagagacaggcatggcaaggaatactgcttaggaccaactcacgaggaa
gccattacggccttaattgcctcccagaagaaactgtcctacaagcagcttcccttcctg
ctgtaccaagtgacaaggaagtttcgggatgagcccaggccccgctttggtcttctccgt
ggccgagagttttacatgaaggatatgtacacctttgactcctccccagaggctgcccag
cagacctacagcctggtgtgtgatgcctactgcagcctgttcaacaagctagggctgcca
tttgtcaaggtccaggccgatgtgggcaccatcgggggcacagtgtctcatgagttccag
ctcccagtggatattggagaggaccggcttgccatctgtccccgctgcagcttctcagcc
aacatggagacactagacttgtcacaaatgaactgccctgcttgccagggcccattgact
aaaaccaaaggcattgaggtggggcacacattttacctgggtaccaagtactcatccatt
ttcaatgcccagtttaccaatgtctgtggcaaaccaaccctggctgaaatggggtgctat
ggcttgggtgtgacacggatcttggctgctgccattgaagtcctctctacagaagactgt
gtccgctggcccagcctactggccccttaccaagcctgcctcatcccccctaagaagggc
agtaaggagcaggcggcctccgagctcatagggcagctgtacgaccacatcacagaggca
gtgcctcagcttcacggggaggtgctcctggacgacaggacccatctgaccatcggaaac
agactgaaagatgccaacaagtttggctacccctttgtgataatcgctggcaagagggcc
ctggaggaccctgcacattttgaggtttggtgtcagaacactggtgaggtggccttcctc
accaaagatggagtcatggatttactgaccccagtgcagactgtctaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
Protein domain (3)   
   Pfam (3)   
All databases (58)   

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