KEGG   Homo sapiens (human): 26173
Entry
26173             CDS       T01001                                 
Symbol
INTS1, INT1, NDCAGF, NET28
Name
(RefSeq) integrator complex subunit 1
  KO
K13138  integrator complex subunit 1
Organism
hsa  Homo sapiens (human)
Disease
H02535  Neurodevelopmental disorder with dysmorphic facies
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    26173 (INTS1)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Proteins involved in snRNP biogenesis
   Integrator complex
    26173 (INTS1)
SSDB
Motif
Pfam: DUF3677 UNC45-central
Other DBs
NCBI-GeneID: 26173
NCBI-ProteinID: NP_001073922
OMIM: 611345
HGNC: 24555
Ensembl: ENSG00000164880
UniProt: Q8N201
Structure
Position
7:complement(1470277..1504389)
AA seq 2190 aa
MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRD
AAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVLPT
VLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATEGV
IEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIW
VDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTELL
IAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGY
KEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLL
NHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMV
FQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFVVH
ITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSI
SKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILVIG
LSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQLP
PGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYPPC
TLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDPQG
PPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSSEG
SLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLLLG
PKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDT
DVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEEQA
QHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGEEV
YSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPL
PTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSK
LLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDSTE
APKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVALAL
QQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLC
QYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGG
LLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEELL
TAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVD
WLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVL
LGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVELIL
AEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRRCR
DLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENRGA
DASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELLQP
HVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFLQK
HADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSLFT
PLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCR
NLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVLLH
RAFLVGMYGQMDPSAQISEALRILHMEAVM
NT seq 6573 nt   +upstreamnt  +downstreamnt
atgaaccgggccaagcccaccacggtgcgccggcccagcgccgcggccaaaccctcaggg
caccctcccccaggagacttcattgctctgggctcaaagggtcaggccaatgaatcgaaa
acggcgtccaccctgctgaagccagccccttccggcctgccttctgagcgcaagcgggat
gcggcggccgcgttgtccagtgcctcggccctcaccggtctcaccaaacgccccaaactc
tcctccacaccccctctgagtgccctggggcgcctggctgaggctgcagtggcagaaaaa
cgagccatttctccgtcgattaaagagccatctgtggtgccaattgaagtgctgcccacg
gtgctgctggatgagatcgaggcggccgagctggagggcaacgatgacaggatcgagggc
gtgctgtgcggggccgtgaagcagctgaaggtcacccgcgccaagcctgacagcaccctc
tacctgagcctcatgtacctggccaagatcaagcccaacatcttcgccactgagggcgtc
attgaggctctgtgtagcctcctgcggcgggacgcctccatcaacttcaaggccaagggg
aacagcctggtgtctgtgctggcctgtaacctcctcatggccgcctacgaggaggacgag
aactggcccgagatctttgtcaaggtgtacatcgaggactccctgggggagcggatctgg
gtggacagccctcactgtaagacgtttgtggacaacatccagacggccttcaacaccaga
atgccccccaggagcgtgctgctgcagggggaggcgggccgcgttgcgggcgacctgggt
gcagggagcagcccacacccctccctcacggaggaggaggacagccagacggagttgctg
atcgcggaggagaagctgagccccgagcaggagggccagctcatgcccaggtacgaagag
ctcgcggagagcgtggaggagtatgtcctggacatgctgcgggaccagctgaaccggcgc
cagcccatcgacaacgtctccaggaacctcctgcggctcctcacctccacctgcggctat
aaggaggtgcggctgctggcggtgcagaagctggagatgtggctgcagaaccccaagctg
acccggccggcccaggacctgctgatgtccgtctgcatgaactgcaacacgcacggttcc
gaagacatggacgtcatctcacacctgatcaagatccgcctcaagcccaaggtcctcctc
aaccacttcatgctgtgcatcagggagctgctgagcgcgcacaaggacaacctgggcacc
accatcaagttggtgatcttcaatgagctctccagcgcccggaacccgaacaacatgcag
gtcctctataccgcactgcagcacagctcagagctggcgcccaagttcctggccatggtg
ttccaggacctgctgaccaacaaggacgactacctgcgggcctcgcgggccctgctgcgg
gagatcatcaagcagaccaagcacgagatcaacttccaggccttctgcctggggctcatg
caggagcgcaaggagccgcagtacctggagatggagttcaaggagcgcttcgtggtgcac
atcaccgacgtcctggccgtgtccatgatgctgggcatcacagcgcaggtgaaggaggcc
ggcatcgcctgggacaaaggagaaaagaggaacctggaagtgctccgctcattccagaac
cagattgccgccatccagcgggatgccgtctggtggctccacactgtggtcccctccatc
agcaagctcgcccctaaggactacgtgcactgcctgcacaaggtgctgttcacagagcag
ccggagacctactacaagtgggacaactggccacccgagagtgaccgcaacttcttcctg
cgtctgtgctccgaggtgcccattttggaggacacgctgatgcgcatcctggtcatcggg
ctgtcccgggagctcccgctcgggcctgcggacgccatggagcttgctgaccacctggtg
aagcgggcggctgccgtgcaggcggatgatgtggaggtgctgaaggtggggaggacccag
ctgatcgacgccgttctgaatctgtgcacctaccatcaccctgaaaacatccagctccca
ccggggtaccagcctccgaacctcgccatctctaccctctactggaaggcctggcccctc
ctgctggtcgtcgccgcattcaacccagagaacatcggcctggctgcgtgggaggagtac
ccgaccctgaagatgctcatggagatggtgatgaccaacaactactcctacccaccgtgc
accctgacggatgaggagacccggacggagatgctgaaccgtgagctgcagaccgcccag
cgggagaagcaggagatcctggccttcgaggggcacctggcggccgcgtccaccaagcag
accatcactgagagcagcagcctcctcctgtcgcagctcaccagcctggacccccagggg
cccccccggaggcctccccctcacatcctggatcaagtgaaaagcctcaaccagtccctc
cgcctcgggcacctcttgtgccgcagccgaaaccctgactttctcctccacatcatccag
cggcaggcctcctcgcagtccatgccctggctggcggacctggtacagtccagcgagggc
tccctggacgtgctgcccgtgcagtgtctgtgcgagttcctgctgcacgatgctgtggac
gatgctgcttccggggaggaggacgacgagggcgagagcaaggagcagaaggccaagaag
cggcagaggcaacagaagcagcggcagctgctgggccgcctgcaggacctgctactgggc
ccgaaggctgatgagcagaccacgtgtgaggtgctggactacttcttgcggcgcctcggc
tcctcccaggtggcctcccgcgtgctggccatgaagggtttgtcgctggtgctttcggag
ggcagcctgcgggacggggaggagaaggagccccccatggaggaggatgtgggggacaca
gatgtgctgcagggctatcagtggctgctgcgggacctgcctcgcctgcctctgttcgac
agcgtcaggagcaccacagccctggccctgcagcaggcaatccacatggagactgatccc
cagaccatcagcgcctacctgatctacttgtcccagcacacgcctgtggaggagcaggcc
cagcacagcgacctggccctggacgtggcccggctggtcgtggagcgctccaccatcatg
tcccacctcttctcgaagctctccccgagtgccgcgtcggacgccgtgctgagcgctctg
ttgtccatcttctcacgctacgtgaggcgcatgcggcagagcaaggagggcgaggaggtc
tacagctggtcggagtctcaggaccaggtcttcctacgctggagcagcggggagacagcc
accatgcacatcctcgtggtccatgccatggtgatcctgctgacgctgggcccgcctcga
gccgacgacagcgagttccaggcgctgctggacatctggtttccggaggagaagccactg
cccaccgccttcctggtggacacatcggaggaggcgctgctgcttcctgactggctgaag
ctgcgcatgatccgttctgaggtgctccgcctggtggacgccgccctgcaggacctggag
ccgcagcagctgctgctgttcgtgcagtcgtttggcatccccgtgtccagcatgagcaaa
ctcctccagttcctggaccaggcagtggcccacgacccccagactctggagcagaacatc
atggacaagaattacatggcccacctggtggaggtccagcatgagcgcggcgcctccgga
ggccagactttccactccttgctcacagcctccctgccgccccgccgagacagcacagag
gcacccaaaccaaagagcagcccagagcagcccataggccagggccggattcgggtgggg
acccagctccgggtgctgggccctgaggacgacctggctggcatgttcctccagattttc
ccgctcagcccggaccctcggtggcagagctccagtccccgccccgtggccctcgccctg
cagcaggccctgggccaggagctggcccgcgtcgtccagggcagccccgaggtgccgggc
atcacggtgcgtgtcctgcaggccctcgccaccctgctcagctccccacacggcggtgcc
ctggtgatgtccatgcaccgtagccacttcctggcctgcccgctgctgcgccagctctgc
cagtaccagcgctgtgtgccacaggacaccggcttctcctcgctcttcctgaaggtgctc
ctgcagatgctgcagtggctggacagccctggcgtggagggcgggcccctgcgggcacag
ctcaggatgcttgccagccaggcctcagccgggcgcaggctcagtgatgtgcgagggggg
ctcctgcgcctggccgaggccctggccttccgtcaggacctggaggtggtcagctccacc
gtccgtgccgtcatcgccaccctgaggtctggggagcagtgcagcgtggagccggacctg
atcagcaaagtcctccaggggctgatcgaggtgaggtccccccacctggaggagctgctg
actgcattcttctctgccactgcggatgctgcctccccgtttccagcctgtaagcccgtt
gtggtggtgagctccctgctgctgcaggaggaggagcccctggctggggggaagccgggt
gcggacggtggcagcctggaggccgtgcggctggggccctcgtcaggcctcctagtggac
tggctggaaatgctggaccccgaggtggtcagcagctgccccgacctgcagctcaggctg
ctcttctcccggaggaagggcaaaggtcaggcccaggtgccctcgttccgtccctacctc
ctgaccctcttcacgcatcagtccagctggcccacactgcaccagtgcatccgagtcctg
ctgggcaagagccgggaacagaggttcgacccctctgcctctctggacttcctctgggcc
tgcatccatgttcctcgcatctggcaggggcgggaccagcgcaccccgcagaagcggcgg
gaggagctggtgctgcgggtccagggcccggagctcatcagcctggtggagctgatcctg
gccgaggcggagacgcggagccaggacggggacacagccgcctgcagcctcatccaggcc
cggctgcccctgctgctcagctgctgctgtggggacgatgagagtgtcaggaaggtgacg
gagcacctgtcaggctgcatccagcagtggggagacagcgtgctgggcaggcgctgccga
gaccttctcctgcagctctacctacagcggccggagctgcgggtgcccgtgcctgaggtc
ctactgcacagcgaaggggctgccagcagcagcgtctgcaagctggacggactcatccac
cgcttcatcacgctccttgcggacaccagcgactcccgggcgttggagaaccgaggggcg
gatgccagcatggcctgccggaagctggcggtggcgcacccgctgctgctgctcaggcac
ctgcccatgatcgcggcgctcctgcacggccgcacccacctcaacttccaggagttccgg
cagcagaaccacctgagctgcttcctgcacgtgctgggcctgctggagctgctgcagccg
cacgtgttccgcagcgagcaccagggggcgctgtgggactgccttctgtccttcatccgc
ctgctgctgaattacaggaagtcctcccgccatctggctgccttcatcaacaagtttgtg
cagttcatccataagtacattacctacaatgccccagcagccatctccttcctgcagaag
cacgccgacccgctccacgacctgtccttcgacaacagtgacctggtgatgctgaaatcc
ctccttgcagggctcagcctgcccagcagggacgacaggaccgaccgaggcctggacgaa
gagggcgaggaggagagctcagccggctccttgcccctggtcagcgtctccctgttcacc
cctctgaccgcggccgagatggccccctacatgaaacggctttcccggggccaaacggtg
gaggatctgctggaggttctgagtgacatagacgagatgtcccggcggagacccgagatc
ctgagcttcttctcgaccaacctgcagcggctgatgagctcggccgaggagtgttgccgc
aacctcgccttcagcctggccctgcgctccatgcagaacagccccagcattgcagccgct
ttcctgcccacgttcatgtactgcctgggcagccaggactttgaggtggtgcagacggcc
ctccggaacctgcctgagtacgctctcctgtgccaagagcacgcggctgtgctgctccac
cgggccttcctggtgggcatgtacggccagatggaccccagcgcgcagatctccgaggcc
ctgaggatcctgcatatggaggccgtgatgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG ORTHOLOGY (1)   
   RefGene (36)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (36)   
   RefSeq(nuc) (4)   
   GenBank (16)   
   EMBL (16)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (99)   

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