KEGG   Homo sapiens (human): 27
Entry
27                CDS       T01001                                 
Symbol
ABL2, ABLL, ARG
Name
(RefSeq) ABL proto-oncogene 2, non-receptor tyrosine kinase
  KO
K08887  abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05416  Viral myocarditis
Network
nt06223  TNF signaling (cancer)
  Element
N01411  Metals to NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    27 (ABL2)
   04014 Ras signaling pathway
    27 (ABL2)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    27 (ABL2)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    27 (ABL2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    27 (ABL2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     27 (ABL2)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  ABL family
   27 (ABL2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase F_actin_bind SH2 SH3_1 SH3_2 SH3_9 SH3_3 Haspin_kinase SH3_6 ABC1 RGS12_us1 Kinase-like
Other DBs
NCBI-GeneID: 27
NCBI-ProteinID: NP_009298
OMIM: 164690
HGNC: 77
Ensembl: ENSG00000143322
UniProt: P42684
Structure
Position
1:complement(179099330..179229677)
AA seq 1182 aa
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
NT seq 3549 nt   +upstreamnt  +downstreamnt
atggggcagcaggtgggccgcgtcggggaagctccggggctccagcagcctcagccccgc
gggatccggggcagcagtgcagccaggccctccggccgcaggcgggacccggcggggcgc
accacagagaccggcttcaatatcttcacccagcatgatcactttgccagctgtgtggag
gatggatttgagggagacaagactggaggcagtagtccagaagctttgcatcgtccctat
ggttgtgatgttgaaccccaggcactaaatgaggctatcaggtggagctccaaggagaac
ttgctcggagccactgagagtgaccctaatctcttcgttgcactttatgattttgtagca
agtggtgataacacactcagcatcactaaaggtgaaaagctacgagtccttggttacaac
cagaatggtgagtggagtgaagttcgctctaagaatgggcagggctgggtgccaagcaac
tacatcaccccagtgaacagcctggaaaaacactcctggtaccatggacctgtgtcacgc
agtgcagctgagtatctgctcagcagtctaatcaatggcagcttcctggtgcgagaaagt
gagagtagccctgggcagctgtccatctcgctcaggtacgagggacgtgtgtatcactac
aggatcaataccactgcagatggcaaggtgtatgtgactgctgagagccgcttcagcacc
ttggcagagcttgtacaccatcactccacagtggctgatgggctggtgacaacattacac
tacccagcacccaagtgtaataagcctacagtctatggtgtgtcccccatccacgacaaa
tgggaaatggagcgaacagatattaccatgaagcacaaacttgggggcggtcagtatgga
gaggtttacgttggcgtctggaagaaatacagccttacagttgctgtgaaaacattgaag
gaagataccatggaggtagaagaattcctgaaagaagctgcagtaatgaaggaaatcaag
catcctaatctggtacaacttttaggtgtgtgtactttggagccaccattttacattgtg
actgaatacatgccatacgggaatttgctggattacctccgagaatgcaaccgagaagag
gtgactgcagttgtgctgctctacatggccactcagatttcttctgcaatggagtactta
gagaagaagaatttcatccatagagatcttgcagctcgtaactgcctagtgggagaaaac
catgtggtaaaagtggctgactttggcttaagtagattgatgactggagacacttatact
gctcatgctggagccaaatttcctattaagtggacagcaccagagagtcttgcctacaat
accttctcaattaaatctgacgtctgggcttttggggtattgttgtgggaaattgctacc
tatggaatgtcaccatatccaggtattgacctgtctcaggtctatgacctactagaaaaa
ggatatcgaatggaacagcctgagggatgcccccctaaggtttatgaacttatgagagca
tgctggaagtggagccctgccgataggccctcttttgctgaaacacaccaagcttttgaa
accatgttccatgactccagcatttctgaagaggtagctgaggagcttgggagagccgcc
tcctcgtcatctgttgttccatacctgccccggctacctatacttccttccaagactcgg
acactgaagaaacaggtggagaacaaggagaacattgaaggggcacaagatgccacagaa
aattctgcttccagtttagcaccagggttcatcagaggtgcacaggcctctagtggatcc
ccagcactgcctcgaaagcaaagagacaagtcacccagcagcctcttggaagatgccaaa
gagacatgcttcaccagggataggaaggggggcttcttcagctccttcatgaagaagaga
aatgctcctacaccccccaaacgcagcagctccttccgagaaatggagaatcagccccat
aagaaatacgaactcacgggtaacttctcatctgttgcttctctacagcatgctgatggg
ttctctttcactcctgcccagcaagaggcgaatctggtgccacccaagtgctatgggggg
agctttgcacagaggaacctctgtaatgacgacggtggtgggggtgggggcagtggcact
gctgggggtgggtggtctggcatcacaggcttctttacaccacgcttaatcaaaaagaca
ctgggcttacgagcaggtaaacccacagccagtgatgacacttccaagccttttccaagg
tcaaactctacatcttccatgtcctcagggcttccagagcaggataggatggcaatgacc
cttcccaggaactgccagaggtccaaactccagctggaaaggacagtgtccacctcttct
cagccagaagagaatgtggacagggccaatgacatgcttccaaaaaaatcagaggaaagt
gctgctccaagcagggagagaccaaaagccaagttattgcccagaggagccacagctctt
cctctcagaacaccctctggggatctagccattacagagaaggaccctccaggggtggga
gtggctggagtggcagctgcccccaagggtaaagagaagaatggtggggcacgacttggg
atggctggagttccagaggatggagagcagccgggctggccttctccagccaaggctgcc
cccgtcctcccaaccactcacaaccacaaagtgccagtccttatctcacccactctgaaa
cacactccagctgacgtgcagctcattggcacagactctcaggggaataaattcaagctc
ttatctgagcatcaggtcacatcctctggagacaaggaccgaccccgacgggtaaaacca
aagtgtgccccacccccaccaccagtgatgagactactgcagcatccgtccatctgctca
gaccctacagaagagccaactgccctaactgcaggacagtccacatcagaaacacaggaa
ggaggaaagaaggcagctctgggcgcagtgcccatcagtgggaaagctgggaggccagtg
atgcctccacctcaagtgcctctgcccacatcttccatctcgccagccaaaatggccaat
ggcacagcaggtactaaagtggctctgagaaaaaccaaacaggccgctgagaaaatctca
gcagacaaaatcagcaaagaggccctgctggaatgtgctgacctactgtccagtgcactc
acggaacctgtgcccaacagccagctggtagacactggacaccagctgcttgactactgc
tcaggctatgtggactgcatccctcaaactcgcaacaaatttgccttccgagaggctgtg
agcaaactggaactcagcctgcaggagctacaggtttcttcagcagctgctggtgtgccc
gggacaaaccctgtccttaataacttattgtcatgtgtacaggaaatcagtgatgtggtg
cagaggtag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (48)   
   RefSeq(nuc) (18)   
   GenBank (15)   
   EMBL (15)   
3D Structure (9)   
   PDB (9)   
Protein domain (13)   
   Pfam (13)   
All databases (114)   

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