KEGG   Homo sapiens (human): 27429
Entry
27429             CDS       T01001                                 
Symbol
HTRA2, MGCA8, OMI, PARK13, PRSS25
Name
(RefSeq) HtrA serine peptidase 2
  KO
K08669  HtrA serine peptidase 2 [EC:3.4.21.108]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06463  Parkinson disease
nt06466  Pathways of neurodegeneration
  Element
N01048  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
Disease
H00057  Parkinson disease
H00754  3-Methylglutaconic aciduria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    27429 (HTRA2)
   04215 Apoptosis - multiple species
    27429 (HTRA2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    27429 (HTRA2)
   05022 Pathways of neurodegeneration - multiple diseases
    27429 (HTRA2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    27429 (HTRA2)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    27429 (HTRA2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.108  HtrA2 peptidase
     27429 (HTRA2)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   27429 (HTRA2)
Chaperones and folding catalysts [BR:hsa03110]
 Other chaperones and cochaperones
  DegP / HtrA
   27429 (HTRA2)
SSDB
Motif
Pfam: Trypsin_2 Trypsin PDZ_6 PDZ_2 PDZ Peptidase_S46 GRASP55_65 Tricorn_PDZ
Other DBs
NCBI-GeneID: 27429
NCBI-ProteinID: NP_037379
OMIM: 606441
HGNC: 14348
Ensembl: ENSG00000115317
UniProt: O43464 A0A384MDW9
Structure
Position
2:74529405..74533556
AA seq 458 aa
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
NT seq 1377 nt   +upstreamnt  +downstreamnt
atggctgcgccgagggcggggcggggtgcaggctggagccttcgggcatggcgggctttg
gggggcattcgctgggggaggagaccccgtttgacccctgacctccgggccctgctgacg
tcaggaacttctgacccccgggcccgagtgacttatgggacccccagtctctgggcccgg
ttgtctgttggggtcactgaaccccgagcatgcctgacgtctgggaccccgggtccccgg
gcacaactgactgcggtgaccccagataccaggacccgggaggcctcagagaactctgga
acccgttcgcgcgcgtggctggcggtggcgctgggcgctgggggggcagtgctgttgttg
ttgtggggcgggggtcggggtcctccggccgtcctcgccgccgtccctagcccgccgccc
gcttctccccggagtcagtacaacttcatcgcagatgtggtggagaagacagcacctgcc
gtggtctatatcgagatcctggaccggcaccctttcttgggccgcgaggtccctatctcg
aacggctcaggattcgtggtggctgccgatgggctcattgtcaccaacgcccatgtggtg
gctgatcggcgcagagtccgtgtgagactgctaagcggcgacacgtatgaggccgtggtc
acagctgtggatcccgtggcagacatcgcaacgctgaggattcagactaaggagcctctc
cccacgctgcctctgggacgctcagctgatgtccggcaaggggagtttgttgttgccatg
ggaagtccctttgcactgcagaacacgatcacatccggcattgttagctctgctcagcgt
ccagccagagacctgggactcccccaaaccaatgtggaatacattcaaactgatgcagct
attgattttggaaactctggaggtcccctggttaacctggatggggaggtgattggagtg
aacaccatgaaggtcacagctggaatctcctttgccatcccttctgatcgtcttcgagag
tttctgcatcgtggggaaaagaagaattcctcctccggaatcagtgggtcccagcggcgc
tacattggggtgatgatgctgaccctgagtcccagcatccttgctgaactacagcttcga
gaaccaagctttcccgatgttcagcatggtgtactcatccataaagtcatcctgggctcc
cctgcacaccgggctggtctgcggcctggtgatgtgattttggccattggggagcagatg
gtacaaaatgctgaagatgtttatgaagctgttcgaacccaatcccagttggcagtgcag
atccggcggggacgagaaacactgaccttatatgtgacccctgaggtcacagaatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (3)   
   KEGG NETWORK (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (30)   
   RefSeq(nuc) (8)   
   GenBank (11)   
   EMBL (11)   
3D Structure (13)   
   PDB (13)   
Protein domain (8)   
   Pfam (8)   
All databases (92)   

Download RDF
DBGET integrated database retrieval system