KEGG   Homo sapiens (human): 3099
Entry
3099              CDS       T01001                                 
Symbol
HK2, HKII, HXK2
Name
(RefSeq) hexokinase 2
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00051  Fructose and mannose metabolism
hsa00052  Galactose metabolism
hsa00500  Starch and sucrose metabolism
hsa00520  Amino sugar and nucleotide sugar metabolism
hsa00524  Neomycin, kanamycin and gentamicin biosynthesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01250  Biosynthesis of nucleotide sugars
hsa04066  HIF-1 signaling pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04973  Carbohydrate digestion and absorption
hsa05131  Shigellosis
hsa05230  Central carbon metabolism in cancer
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
hsa_M00892  UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc
Network
nt06524  Apoptosis
  Element
N00950  Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways
Drug target
Lonidamine: D07257
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    3099 (HK2)
   00051 Fructose and mannose metabolism
    3099 (HK2)
   00052 Galactose metabolism
    3099 (HK2)
   00500 Starch and sucrose metabolism
    3099 (HK2)
   00520 Amino sugar and nucleotide sugar metabolism
    3099 (HK2)
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    3099 (HK2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    3099 (HK2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    3099 (HK2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    3099 (HK2)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    3099 (HK2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    3099 (HK2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    3099 (HK2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3099 (HK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     3099 (HK2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    3099 (HK2)
SSDB
Motif
Pfam: Hexokinase_2 Hexokinase_1 FGGY_N PMT_C3 CCDC66
Other DBs
NCBI-GeneID: 3099
NCBI-ProteinID: NP_000180
OMIM: 601125
HGNC: 4923
Ensembl: ENSG00000159399
UniProt: P52789
Structure
Position
2:74834127..74893359
AA seq 917 aa
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS
HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
AALITAVACRIREAGQR
NT seq 2754 nt   +upstreamnt  +downstreamnt
atgattgcctcgcatctgcttgcctacttcttcacggagctcaaccatgaccaagtgcag
aaggttgaccagtatctctaccacatgcgcctctctgatgagaccctcttggagatctct
aagcggttccgcaaggagatggagaaagggcttggagccaccactcaccctactgcagca
gtgaagatgctgcccacctttgtgaggtccactccagatgggacagaacacggagagttc
ctggctctggatcttggagggaccaacttccgtgtgctttgggtgaaagtaacggacaat
gggctccagaaggtggagatggagaatcagatctatgccatccctgaggacatcatgcga
ggcagtggcacccagctgtttgaccacattgccgaatgcctggctaacttcatggataag
ctacaaatcaaagacaagaagctcccactgggttttaccttctcgttcccctgccaccag
actaaactagacgagagtttcctggtctcatggaccaagggattcaagtccagtggagtg
gaaggcagagacgttgtggctctgatccggaaggccatccagaggagaggggactttgat
atcgacattgtggctgtggtgaatgacacagttgggaccatgatgacctgtggttatgat
gaccacaactgtgagattggtctcattgtgggcacgggcagcaacgcctgctacatggaa
gagatgcgccacatcgacatggtggaaggcgatgaggggcggatgtgtatcaatatggag
tggggggccttcggggacgatggctcgctcaacgacattcgcactgagtttgaccaggag
attgacatgggctcactgaacccgggaaagcaactgtttgagaagatgatcagtgggatg
tacatgggggagctggtgaggcttatcctggtgaagatggccaaggaggagctgctcttt
ggggggaagctcagcccagagcttctcaacaccggtcgctttgagaccaaagacatctca
gacattgaaggggagaaggatggcatccggaaggcccgtgaggtcctgatgcggttgggc
ctggacccgactcaggaggactgcgtggccactcaccggatctgccagatcgtgtccaca
cgctccgccagcctgtgcgcagccaccctggccgccgtgctgcagcgcatcaaggagaac
aaaggcgaggagcggctgcgctctactattggggtcgacggttccgtctacaagaaacac
ccccattttgccaagcgtctacataagaccgtgcggcggctggtgcccggctgcgatgtc
cgcttcctccgctccgaggatggcagtggcaaaggtgcagccatggtgacagcagtggct
taccggctggccgatcaacaccgtgcccgccagaagacattagagcatctgcagctgagc
catgaccagctgctggaggtcaagaggaggatgaaggtagaaatggagcgaggtctgagc
aaggagactcatgccagtgcccccgtcaagatgctgcccacctacgtgtgtgctaccccg
gacggcacagagaaaggggacttcttggccttggaccttggaggaacaaatttccgggtc
ctgctggtccgtgttcggaatgggaagtggggtggagtggagatgcacaacaagatctac
gccatcccgcaggaggtcatgcacggcaccggggacgagctctttgaccacattgtccag
tgcatcgcggacttcctcgagtacatgggcatgaagggcgtgtccctgcctctgggtttt
accttctccttcccctgccagcagaacagcctggacgagagcatcctcctcaagtggaca
aaaggcttcaaggcatctggctgcgagggcgaggacgtggtgaccctgctgaaggaagcg
atccaccggcgagaggagtttgacctggatgtggttgctgtggtgaacgacacagtcgga
actatgatgacctgtggctttgaagaccctcactgtgaagttggcctcattgttggcacg
ggcagcaatgcctgctacatggaggagatgcgcaacgtggaactggtggaaggagaagag
gggcggatgtgtgtgaacatggaatggggggccttcggggacaatggatgcctagatgac
ttccgcacagaatttgatgtggctgtggatgagctttcactcaaccccggcaagcagagg
ttcgagaaaatgatcagtggaatgtacctgggtgagattgtccgtaacattctcatcgat
ttcaccaagcgtggactactcttccgaggccgcatctcagagcggctcaagacaaggggc
atctttgaaaccaagttcttgtctcagattgagagtgactgcctggccctgctgcaagtc
cgagccatcctgcaacacttagggcttgagagcacctgtgacgacagcatcattgttaag
gaggtgtgcactgtggtggcccggcgggcagcccagctctgtggcgcaggcatggccgct
gtggtggacaggatacgagaaaaccgtgggctggacgctctcaaagtgacagtgggtgtg
gatgggaccctctacaagctacatcctcactttgccaaagtcatgcatgagacagtgaag
gacctggctccgaaatgtgatgtgtctttcctgcagtcagaggatggcagcgggaagggg
gcggcgctcatcactgctgtggcctgccgcatccgtgaggctggacagcgatag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (18)   
   KEGG PATHWAY (15)   
   KEGG MODULE (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (16)   
   KEGG COMPOUND (16)   
Chemical reaction (9)   
   KEGG ENZYME (1)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (35)   
   RefSeq(nuc) (11)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (118)   

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