KEGG   Homo sapiens (human): 3310
Entry
3310              CDS       T01001                                 
Symbol
HSPA6, HSP70B'
Name
(RefSeq) heat shock protein family A (Hsp70) member 6
  KO
K03283  heat shock 70kDa protein 1/6/8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03040  Spliceosome
hsa04010  MAPK signaling pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04144  Endocytosis
hsa04213  Longevity regulating pathway - multiple species
hsa04612  Antigen processing and presentation
hsa04915  Estrogen signaling pathway
hsa05020  Prion disease
hsa05134  Legionellosis
hsa05145  Toxoplasmosis
hsa05162  Measles
hsa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    3310 (HSPA6)
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    3310 (HSPA6)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3310 (HSPA6)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3310 (HSPA6)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    3310 (HSPA6)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    3310 (HSPA6)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    3310 (HSPA6)
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    3310 (HSPA6)
  09171 Infectious disease: bacterial
   05134 Legionellosis
    3310 (HSPA6)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3310 (HSPA6)
  09164 Neurodegenerative disease
   05020 Prion disease
    3310 (HSPA6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3310 (HSPA6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    3310 (HSPA6)
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    3310 (HSPA6)
   03009 Ribosome biogenesis [BR:hsa03009]
    3310 (HSPA6)
   03110 Chaperones and folding catalysts [BR:hsa03110]
    3310 (HSPA6)
   04131 Membrane trafficking [BR:hsa04131]
    3310 (HSPA6)
   03051 Proteasome [BR:hsa03051]
    3310 (HSPA6)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3310 (HSPA6)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3310 (HSPA6)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-5
    PP5-interacting proteins
     3310 (HSPA6)
Spliceosome [BR:hsa03041]
 Complex B
  Other components
   Prp19 complex
    3310 (HSPA6)
 Complex C
   Prp19-CDC5 complex
    3310 (HSPA6)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  Pre-60S particles
   Export and cytoplasmic maturation factors
    3310 (HSPA6)
Chaperones and folding catalysts [BR:hsa03110]
 Heat shock proteins
  HSP70 / DNAK
   3310 (HSPA6)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Other core components
    3310 (HSPA6)
 Autophagy
  Chaperone mediated autophagy (CMA)
   Chaperones
    3310 (HSPA6)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    3310 (HSPA6)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial protein import machinery
  Endoplasmic reticulum membrane and cytosol
   Other ER-memrane and cytosol factors
    3310 (HSPA6)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   3310 (HSPA6)
SSDB
Motif
Pfam: HSP70 MreB_Mbl FGGY_C Hydantoinase_A DUF1464
Other DBs
NCBI-GeneID: 3310
NCBI-ProteinID: NP_002146
OMIM: 140555
HGNC: 5239
Ensembl: ENSG00000173110
UniProt: P17066 B3KSM6 A0A384NKX5
Structure
Position
1:161524540..161526894
AA seq 643 aa
MQAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQ
AALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEE
ISSMVLSKMKETAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTA
AAIAYGLDRRGAGERNVLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLV
NHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSIT
RARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKE
LNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLLDVAPLSLGLETAGGVMTTLIQRNA
TIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTF
DIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQYKAEDEAQRDRVAA
KNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEKEEYEHQKRE
LEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD
NT seq 1932 nt   +upstreamnt  +downstreamnt
atgcaggccccacgggagctcgcggtgggcatcgacctgggcaccacctactcgtgcgtg
ggcgtgtttcagcagggccgcgtggagatcctggccaacgaccagggcaaccgcaccacg
cccagctacgtggccttcaccgacaccgagcggctggtcggggacgcggccaagagccag
gcggccctgaacccccacaacaccgtgttcgatgccaagcggctgatcgggcgcaagttc
gcggacaccacggtgcagtcggacatgaagcactggcccttccgggtggtgagcgagggc
ggcaagcccaaggtgcgcgtatgctaccgcggggaggacaagacgttctaccccgaggag
atctcgtccatggtgctgagcaagatgaaggagacggccgaggcgtacctgggccagccc
gtgaagcacgcagtgatcaccgtgcccgcctatttcaatgactcgcagcgccaggccacc
aaggacgcgggggccatcgcggggctcaacgtgttgcggatcatcaatgagcccacggca
gctgccatcgcctatgggctggaccggcggggcgcgggagagcgcaacgtgctcattttt
gacctgggtgggggcaccttcgatgtgtcggttctctccattgacgctggtgtctttgag
gtgaaagccactgctggagatacccacctgggaggagaggacttcgacaaccggctcgtg
aaccacttcatggaagaattccggcggaagcatgggaaggacctgagcgggaacaagcgt
gccctgcgcaggctgcgcacagcctgtgagcgcgccaagcgcaccctgtcctccagcacc
caggccaccctggagatagactccctgttcgagggcgtggacttctacacgtccatcact
cgtgcccgctttgaggaactgtgctcagacctcttccgcagcaccctggagccggtggag
aaggccctgcgggatgccaagctggacaaggcccagattcatgacgtcgtcctggtgggg
ggctccacacgcatccccaaggtgcagaagttgctgcaggacttcttcaacggcaaggag
ctgaacaagagcatcaaccctgatgaggctgtggcctatggggctgctgtgcaggcggcc
gtgttgatgggggacaaatgtgagaaagtgcaggatctcctgctgctggatgtggctccc
ctgtctctggggctggagacagcaggtggggtgatgaccacgctgatccagaggaacgcc
actatccccaccaagcagacccagactttcaccacctactcggacaaccagcctggggtc
ttcatccaggtgtatgagggtgagagggccatgaccaaggacaacaacctgctggggcgt
tttgaactcagtggcatccctcctgccccacgtggagtcccccagatagaggtgactttt
gacattgatgctaatggcatcctgagcgtgacagccactgacaggagcacaggtaaggct
aacaagatcaccatcaccaatgacaagggccggctgagcaaggaggaggtggagaggatg
gttcatgaagccgagcagtacaaggctgaggatgaggcccagagggacagagtggctgcc
aaaaactcgctggaggcccatgtcttccatgtgaaaggttctttgcaagaggaaagcctt
agggacaagattcccgaagaggacaggcgcaaaatgcaagacaagtgtcgggaagtcctt
gcctggctggagcacaaccagctggcagagaaggaggagtatgagcatcagaagagggag
ctggagcaaatctgtcgccccatcttctccaggctctatggggggcctggtgtccctggg
ggcagcagttgtggcactcaagcccgccagggggaccccagcaccggccccatcattgag
gaggttgattga

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Ontology (9)   
   KEGG BRITE (9)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   RefGene (33)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (5)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (99)   

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