KEGG   Homo sapiens (human): 3776
Entry
3776              CDS       T01001                                 
Symbol
KCNK2, K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e
Name
(RefSeq) potassium two pore domain channel subfamily K member 2
  KO
K04913  potassium channel subfamily K member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    3776 (KCNK2)
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    3776 (KCNK2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    3776 (KCNK2)
  09154 Digestive system
   04971 Gastric acid secretion
    3776 (KCNK2)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    3776 (KCNK2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3776 (KCNK2)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, two-pore domain (K2P)
   3776 (KCNK2)
SSDB
Motif
Pfam: Ion_trans_2 Ion_trans bZIP_Maf
Other DBs
NCBI-GeneID: 3776
NCBI-ProteinID: NP_001017425
OMIM: 603219
HGNC: 6277
Ensembl: ENSG00000082482
UniProt: O95069 Q6ZW95
Structure
Position
1:215005542..215237090
AA seq 426 aa
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
NT seq 1281 nt   +upstreamnt  +downstreamnt
atgcttcccagcgcctcgcgggagagacccggctatagagcaggagtggcggcacctgac
ttgctggatcctaaatctgccgctcagaactccaaaccgaggctctcgttttccacgaaa
cccacagtgcttgcttcccgggtggagagtgacacgaccattaatgttatgaaatggaag
acggtctccacgatattcctggtggttgtcctctatctgatcatcggagccaccgtgttc
aaagcattggagcagcctcatgagatttcacagaggaccaccattgtgatccagaagcaa
acattcatatcccaacattcctgtgtcaattcgacggagctggatgaactcattcagcaa
atagtggcagcaataaatgcagggattataccgttaggaaacacctccaatcaaatcagt
cactgggatttgggaagttccttcttctttgctggcactgttattacaaccataggattt
ggaaacatctcaccacgcacagaaggcggcaaaatattctgtatcatctatgccttactg
ggaattcccctctttggttttctcttggctggagttggagatcagctaggcaccatattt
ggaaaaggaattgccaaagtggaagatacgtttattaagtggaatgttagtcagaccaag
attcgcatcatctcaacaatcatatttatactatttggctgtgtactctttgtggctctg
cctgcgatcatattcaaacacatagaaggctggagtgccctggacgccatttattttgtg
gttatcactctaacaactattggatttggtgactacgttgcaggtggatccgatattgaa
tatctggacttctataagcctgtcgtgtggttctggatccttgtagggcttgcttacttt
gctgctgtcctgagcatgattggagattggctccgagtgatatctaaaaagacaaaagaa
gaggtgggagagttcagagcacacgctgctgagtggacagccaacgtcacagccgaattc
aaagaaaccaggaggcgactgagtgtggagatttatgacaagttccagcgggccacctcc
atcaagcggaagctctcggcagaactggctggaaaccacaatcaggagctgactccttgt
aggaggaccctgtcagtgaaccacctgaccagcgagagggatgtcttgcctcccttactg
aagactgagagtatctatctgaatggtttgacgccacactgtgctggtgaagagattgct
gtgattgagaacatcaaatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (55)   
   RefSeq(nuc) (9)   
   GenBank (23)   
   EMBL (23)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (88)   

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