KEGG   Homo sapiens (human): 4190
Entry
4190              CDS       T01001                                 
Symbol
MDH1, DEE88, EIEE88, HEL-S-32, KAR, MDH-s, MDHA, MGC:1375, MOR2
Name
(RefSeq) malate dehydrogenase 1
  KO
K00025  malate dehydrogenase [EC:1.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00270  Cysteine and methionine metabolism
hsa00620  Pyruvate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04964  Proximal tubule bicarbonate reclamation
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01605  Gluconeogenesis
N01617  Citrate cycle, second carbon oxidation 2
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    4190 (MDH1)
   00620 Pyruvate metabolism
    4190 (MDH1)
   00630 Glyoxylate and dicarboxylate metabolism
    4190 (MDH1)
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    4190 (MDH1)
 09150 Organismal Systems
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    4190 (MDH1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     4190 (MDH1)
SSDB
Motif
Pfam: Ldh_1_C Ldh_1_N Glyco_hydro_3_C DM13
Other DBs
NCBI-GeneID: 4190
NCBI-ProteinID: NP_005908
OMIM: 154200
HGNC: 6970
Ensembl: ENSG00000014641
UniProt: P40925 V9HWF2
Structure
Position
2:63588963..63607197
AA seq 334 aa
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
NT seq 1005 nt   +upstreamnt  +downstreamnt
atgtctgaaccaatcagagtccttgtgactggagcagctggtcaaattgcatattcactg
ctgtacagtattggaaatggatctgtctttggtaaagatcagcctataattcttgtgctg
ttggatatcacccccatgatgggtgtcctggacggtgtcctaatggaactgcaagactgt
gcccttcccctcctgaaagatgtcatcgcaacagataaagaagacgttgccttcaaagac
ctggatgtggccattcttgtgggctccatgccaagaagggaaggcatggagagaaaagat
ttactgaaagcaaatgtgaaaatcttcaaatcccagggtgcagccttagataaatacgcc
aagaagtcagttaaggttattgttgtgggtaatccagccaataccaactgcctgactgct
tccaagtcagctccatccatccccaaggagaacttcagttgcttgactcgtttggatcac
aaccgagctaaagctcaaattgctcttaaacttggtgtgactgctaatgatgtaaagaat
gtcattatctggggaaaccattcctcgactcagtatccagatgtcaaccatgccaaggtg
aaattgcaaggaaaggaagttggtgtttatgaagctctgaaagatgacagctggctcaag
ggagaatttgtcacgactgtgcagcagcgtggcgctgctgtcatcaaggctcgaaaacta
tccagtgccatgtctgctgcaaaagccatctgtgaccacgtcagggacatctggtttgga
accccagagggagagtttgtgtccatgggtgttatctctgatggcaactcctatggtgtt
cctgatgatctgctctactcattccctgttgtaatcaagaataagacctggaagtttgtt
gaaggtctccctattaatgatttctcacgtgagaagatggatcttactgcaaaggaactg
acagaagaaaaagaaagtgcttttgaatttctttcctctgcctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (7)   
   KEGG MODULE (5)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (21)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (4)   
All databases (111)   

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